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On the Origin of Leprosy

by Fine, Paul E , Garnier, Thierry , Convit, Jacinto , Araoz, Romulo , Truman, Richard W , Paniz-Mondolfi, Alberto , Brennan, Patrick J , Cho, Sang-Nae , Rasolofo, Voahangy , Gelber, Robert , Ji, Baohong , Cole, Stewart T , Monot, Marc , Williams, Diana L , Honoré, Nadine , Spencer, John S , Young, Saroj , Flageul, Béatrice , Sow, Samba , Coppée, Jean-Yves , Virmond, Marcos , Lacroix, Céline

in Africa / Africa - epidemiology / Africans / Americas / Americas - epidemiology / Armadillos / Asia / Asia - epidemiology / Bacterial diseases / Bacteriology / Biochemistry, Molecular Biology / Biological and medical sciences / Biological Evolution / Coding / Comparative analysis / Demography / Eastern Africa / Emigration and Immigration / Europe / Europe - epidemiology / Europeans / Evolution / Genes, Bacterial / Genetic aspects / Genome, Bacterial / Genomes / Genomics / Geographic regions / History, 18th Century / History, 19th Century / History, Ancient / History, Medieval / Human bacterial diseases / human diseases / Human populations / Humans / immigration / Infectious diseases / Interspersed Repetitive Sequences / Leprosy / Leprosy - epidemiology / Leprosy - history / Leprosy - microbiology / Leprosy - transmission / Life Sciences / Medical sciences / Middle East / Minisatellite Repeats / Molecular biology / Mycobacterium leprae / Mycobacterium leprae - classification / Mycobacterium leprae - genetics / North America / Oligonucleotide Array Sequence Analysis / Pathogens / Pathology / Polymorphism, Single Nucleotide / Population Dynamics / Pseudogenes / Sequence Analysis, DNA / single nucleotide polymorphism / South America / Topology / Tropical bacterial diseases / Tuberculosis / Western Africa

2005

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On the Origin of Leprosy

2005

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On the Origin of Leprosy

2005

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Journal Article

On the Origin of Leprosy

Fine, Paul E,

Garnier, Thierry,

Convit, Jacinto,

Araoz, Romulo,

Truman, Richard W,

Paniz-Mondolfi, Alberto,

Brennan, Patrick J,

Cho, Sang-Nae,

Rasolofo, Voahangy,

Gelber, Robert,

Ji, Baohong,

Cole, Stewart T,

Monot, Marc,

Williams, Diana L,

Honoré, Nadine,

Spencer, John S,

Young, Saroj,

Flageul, Béatrice,

Sow, Samba,

Coppée, Jean-Yves,

Virmond, Marcos,

Lacroix, Céline

2005

Overview

Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease seems to have originated in Eastern Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science,American Association for the Advancement of Science (AAAS)

Subject

Africa

/ Africa - epidemiology

/ Africans

/ Americas

/ Americas - epidemiology

/ Armadillos

/ Asia

/ Asia - epidemiology

/ Bacterial diseases

/ Bacteriology

/ Biochemistry, Molecular Biology