Asset Details
Do you wish to reserve the book?
MoxR effects as an ATPase on anti-stress and pathogenicity of Riemerella anatipestifer
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
MoxR effects as an ATPase on anti-stress and pathogenicity of Riemerella anatipestifer
Do you wish to request the book?
MoxR effects as an ATPase on anti-stress and pathogenicity of Riemerella anatipestifer
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
MoxR effects as an ATPase on anti-stress and pathogenicity of Riemerella anatipestifer
2025
Overview
Duck infectious serositis is a septicemic disease caused by the bacterium
Riemerella anatipestifer
(
R. anatipestifer
), which affects ducks, geese, turkeys, and other poultry. While outbreaks have been reported worldwide, the exact mechanisms of infection and disease progression remain unclear. Our previous research identified the two-component system PhoPR within the genome of
R. anatipestifer
and demonstrated its association with the bacterium’s pathogenicity. Through multi-omics analysis, we found that PhoP directly regulates the expression of several genes, including
moxR
, within the
Bacteroides aerotolerance
(Bat) operon. However, the function of MoxR in
R. anatipestifer
has not yet been reported. To investigate the impact of MoxR on the expression of the
bat
operon and the pathogenicity of
R. anatipestifer
, we constructed Δ
moxR
and other derivative strains. Our findings revealed that overexpression of MoxR inhibits the transcription of the
bat
operon. Conversely, deletion of
moxR
, along with exposure of
R. anatipestifer
to thermal or oxidative stress, results in increased transcription levels of the
bat
operon. By measuring the survival ability of each strain under stress, we discovered that MoxR is closely associated with the resistance of
R. anatipestifer
to thermal and oxidative stress by influencing the expression of the
bat
operon. Duckling infection experiments, along with adhesion and invasion assays, showed that deletion of
moxR
in
R. anatipestifer
led to decreased pathogenicity, and lower bacterial load in various tissues. Collectively, our findings collectively demonstrate the significant role of MoxR in the anti-stress and pathogenicity of
R. anatipestifer
, providing new insights into its pathogenic mechanisms.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Adenosine Triphosphatases - genetics
/ Adenosine Triphosphatases - metabolism
/ adhesion
/ Animals
/ bacteria
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Bats
/ Ducks
/ Flavobacteriaceae Infections - microbiology
/ Flavobacteriaceae Infections - veterinary
/ Gene Expression Regulation, Bacterial
/ Genes
/ Genomes
/ Genomics
/ Medicine
/ MoxR
/ operon
/ Poultry Diseases - microbiology
/ stress
/ Veterinary Medicine/Veterinary Science
/ Virology
