Journal Article

Chinese Herbal Medicine Treatment Improves the Overall Survival Rate of Individuals with Hypertension among Type 2 Diabetes Patients and Modulates In Vitro Smooth Muscle Cell Contractility

Ho, Tsung-Jung, Shiao, Yi-Tzone, Liu, Xiang, Cheng, Chi-Fung, Liu, Yu-Huei, Yeh, Yi-Chun, Chien, Wen-Kuei, Tsang, Hsinyi, Huang, Shao-Mei, Li, Ju-Pi, Liang, Wen-Miin, Lin, Ting-Hsu, Lan, Yu-Ching, Tsai, Fuu-Jen, Chen, Jin-Hua, Lin, Cheng-Wen, Wang, Chang-Bi, Chen, Shih-Yin, Pang, Hao-Yu, Liao, Chiu-Chu, Lin, Jaung-Geng, Lin, Ying-Ju

2015

Overview

Type 2 diabetes (T2D) is a chronic, multifactorial, and metabolic disorder accounting for 90% diabetes cases worldwide. Among them, almost half of T2D have hypertension, which is responsible for cardiovascular disease, morbidity, and mortality in these patients. The Chinese herbal medicine (CHM) prescription patterns of hypertension individuals among T2D patients have yet to be characterized. This study, therefore, aimed to determine their prescription patterns and evaluate the CHM effect. A cohort of one million randomly sampled cases from the National Health Insurance Research Database (NHIRD) was used to investigate the overall survival rate of CHM users, and prescription patterns. After matching CHM and non-CHM users for age, gender and date of diagnosis of hypertension, 980 subjects for each group were selected. The CHM users were characterized with slightly longer duration time from diabetes to hypertension, and more cases for hyperlipidaemia. The cumulative survival probabilities were higher in CHM users than in non-CHM users. Among these top 12 herbs, Liu-Wei-Di-Huang-Wan, Jia-Wei-Xiao-Yao-San, Dan-Shen, and Ge-Gen were the most common herbs and inhibited in vitro smooth muscle cell contractility. Our study also provides a CHM comprehensive list that may be useful in future investigation of the safety and efficacy for individuals with hypertension among type 2 diabetes patients.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Aged / Aged, 80 and over / Blood pressure / Blotting, Western / Breast cancer / Cardiovascular disease / Cardiovascular diseases / Case-Control Studies / Cells, Cultured / Chinese medicine / Complementary Therapies / Diabetes / Diabetes mellitus / Diabetes Mellitus, Type 2 - complications / Diabetes Mellitus, Type 2 - mortality / Diabetes Mellitus, Type 2 - pathology / Diabetes therapy / Diabetic retinopathy / Drug Prescriptions / Female / Health insurance / Herbal medicine / Herbs / Hospitals / Humans / Hyperlipidemia / Hypertension / Hypertension - etiology / Hypertension - mortality / Hypertension - pathology / In Vitro Techniques / Infectious diseases / Insulin / Male / Medical laboratories / Medical research / Medicine / Medicine, Chinese Traditional - utilization / Metabolic disorders / Middle Aged / Morbidity / Mortality / Muscle contraction / Muscle Contraction - drug effects / Muscles / Myocytes, Smooth Muscle - drug effects / Myocytes, Smooth Muscle - pathology / National health insurance / Online databases / Patient outcomes / Patients / Population / Public health / Retrospective Studies / Smooth muscle / Studies / Survival / Traditional Chinese medicine / Type 2 diabetes