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Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption
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Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption
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Journal Article
Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption
1999
Overview
Epithelia permit selective and regulated flux from apical to basolateral surfaces by transcellular passage through cells or paracellular flux between cells. Tight junctions constitute the barrier to paracellular conductance; however, little is known about the specific molecules that mediate paracellular permeabilities. Renal magnesium ion (Mg2+) resorption occurs predominantly through a paracellular conductance in the thick ascending limb of Henle (TAL). Here, positional cloning has identified a human gene, paracellin-1 (PCLN-1), mutations in which cause renal Mg2+ wasting. PCLN-1 is located in tight junctions of the TAL and is related to the claudin family of tight junction proteins. These findings provide insight into Mg2+ homeostasis, demonstrate the role of a tight junction protein in human disease, and identify an essential component of a selective paracellular conductance.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Biological and medical sciences
/ Chromosomes, Human, Pair 3 - genetics
/ Claudins
/ Cloning
/ Coding
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Genes
/ Humans
/ Kidney Diseases - metabolism
/ Magnesium Deficiency - genetics
/ Magnesium Deficiency - metabolism
/ Male
/ Membrane and intracellular transports
/ Membrane Proteins - analysis
/ Membrane Proteins - chemistry
/ Membrane Proteins - genetics
/ Membrane Proteins - physiology
/ Molecular and cellular biology
/ Mutation
/ Patients
/ Pedigree
/ Proteins
