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Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions
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Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions
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Journal Article
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions
2012
Overview
In normal human somatic cells, telomere dysfunction causes cellular senescence, a stable proliferative arrest with tumour suppressing properties. Whether telomere dysfunction‐induced senescence (TDIS) suppresses cancer growth in humans, however, is unknown. Here, we demonstrate that multiple and distinct human cancer precursor lesions, but not corresponding malignant cancers, are comprised of cells that display hallmarks of TDIS. Furthermore, we demonstrate that oncogenic signalling, frequently associated with initiating cancer growth in humans, dramatically affected telomere structure and function by causing telomeric replication stress, rapid and stochastic telomere attrition, and consequently telomere dysfunction in cells that lack hTERT activity. DNA replication stress induced by drugs also resulted in telomere dysfunction and cellular senescence in normal human cells, demonstrating that telomeric repeats indeed are hypersensitive to DNA replication stress. Our data reveal that TDIS, accelerated by oncogene‐induced DNA replication stress, is a biological response of cells in human cancer precursor lesions and provide strong evidence that TDIS is a critical tumour suppressing mechanism in humans.
This study offers a novel view on the role of telomere attrition in human tumours, providing evidence for tumour suppressor activity resulting from telomere dysfunction‐induced DNA damage responses.
Publisher
John Wiley & Sons, Ltd,Nature Publishing Group UK,Springer Nature B.V,Nature Publishing Group
Subject
/ Cell Transformation, Neoplastic - drug effects
/ Cell Transformation, Neoplastic - genetics
/ Cellular Senescence - drug effects
/ Cellular Senescence - genetics
/ Cellular Senescence - physiology
/ DNA
/ DNA Replication - drug effects
/ DNA Replication - physiology
/ EMBO24
/ EMBO37
/ Humans
/ Lesions
/ oncogene
/ Oncology
/ Protein Synthesis Inhibitors - pharmacology
/ Signal Transduction - drug effects
/ Signal Transduction - genetics
/ Signal Transduction - physiology
/ Stress
/ Tumors
