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Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis

by Xing, Changying , Liu, Bi-Cheng , Cai, Guang-Yan , Hao, Chuanming , Wang, Jianqin , Wang, Chunrong , Jiang, Gengru , Wang, Caili , Liu, Zhihong , Leong, Robert , Liu, Zhengrong , Zuo, Li , Luo, Laimin , Zhao, Ming-hui , Neff, Thomas , Yu, Kin-Hung P , Chen, Nan , Hao, Li , Lin, Hongli , Liang, Xinling , Liu, Cameron , Szczech, Lynda , Li, Xuemei

in Adult / Aged / Analysis of Variance / Anemia / Anemia - drug therapy / Anemia - etiology / Biomarkers / Cholesterol / Cholesterol - blood / Dialysis / Double-Blind Method / Epoetin Alfa - adverse effects / Epoetin Alfa - therapeutic use / Erythropoiesis / Erythropoietin / Female / Glycine - adverse effects / Glycine - analogs & derivatives / Glycine - therapeutic use / Hematinics - adverse effects / Hematinics - therapeutic use / Hemoglobin / Hemoglobins - analysis / Hepcidin / Humans / Hyperkalemia / Hyperkalemia - chemically induced / Hypertension - chemically induced / Hypoxia / Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors / Hypoxia-inducible factors / Iron / Isoquinolines - adverse effects / Isoquinolines - therapeutic use / Kidney diseases / Male / Middle Aged / Patients / Peritoneal dialysis / Potassium / Prolyl hydroxylase / Renal Dialysis / Renal Insufficiency, Chronic - blood / Renal Insufficiency, Chronic - complications / Renal Insufficiency, Chronic - therapy / Transferrins

2019

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Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis

2019

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2019

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Journal Article

Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis

Xing, Changying,

Liu, Bi-Cheng,

Cai, Guang-Yan,

Hao, Chuanming,

Wang, Jianqin,

Wang, Chunrong,

Jiang, Gengru,

Wang, Caili,

Liu, Zhihong,

Leong, Robert,

Liu, Zhengrong,

Zuo, Li,

Luo, Laimin,

Zhao, Ming-hui,

Neff, Thomas,

Yu, Kin-Hung P,

Chen, Nan,

Hao, Li,

Lin, Hongli,

Liang, Xinling,

Liu, Cameron,

Szczech, Lynda,

Li, Xuemei

2019

Overview

This randomized, phase 3 trial compared the effectiveness of roxadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, with epoetin alfa in patients undergoing hemodialysis or peritoneal dialysis in China. Oral roxadustat was noninferior to parenteral epoetin alfa as therapy for anemia.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Aged

/ Analysis of Variance

/ Anemia

/ Anemia - drug therapy

/ Anemia - etiology

/ Biomarkers