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A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

by Guo, Li , Zhang, Dingyu , Qu, Zhaohui , Peng, Lu , Li, Kunxia , Jaki, Thomas , Ruan, Shunan , Hayden, Frederick G , Chen, Nanshan , He, Jing , Shang, Lianhan , Zou, Jun , Xie, Xuelei , Wu, Xudong , Bai, Tao , Li, Caihong , Wang, Shuzhen , Zhan, Haiyan , Song, Bin , Wang, Yeming , Yuan, Ye , Wang, Ke , Xiang, Jie , Ge, Qin , Fan, Guohui , Dong, Xuan , Liu, Ying , Wang, Jingli , Zhou, Xia , Lu, Sixia , Xia, Jiaan , Xu, Jiuyang , Li, Huadong , Zhou, Fei , Liu, Wen , Luo, Shanshan , Yu, Ting , Hu, Xujuan , Gong, Fengyun , Zhang, Yi , Cheng, Fang , Huang, Chaolin , Wei, Yuan , Huang, Hanping , Pan, Lihong , Chen, Hua , Jia, Chunmin , Gu, Xiaoying , Dong, Chongya , Wei, Ming , Zhang, Li , Liu, Zhibo , Li, Hui , Ruan, Lianguo , Wang, Juan , Liu, Xia , Wu, Jing , Qiu, Fang , Wen, Danning , Tu, Shengjing , Cao, Bin , Cai, Yanping , Horby, Peter W , Li, Xingwang , Wang, Chen

in Adult / Aged / Antiretroviral drugs / Antiviral Agents - adverse effects / Antiviral Agents - therapeutic use / Antiviral drugs / Betacoronavirus - genetics / Betacoronavirus - isolation & purification / Clinical Laboratory Techniques / Clinical outcomes / Clinical trials / Coronavirus Infections - diagnosis / Coronavirus Infections - drug therapy / Coronavirus Infections - mortality / Coronavirus Infections - virology / Coronaviruses / COVID-19 / COVID-19 Testing / Cytochrome P-450 CYP3A Inhibitors - adverse effects / Cytochrome P-450 CYP3A Inhibitors - therapeutic use / Drug Therapy, Combination / Female / HIV / Hospital Mortality / Human immunodeficiency virus / Humans / Influenza / Intention to Treat Analysis / Laboratories / Lopinavir / Lopinavir - adverse effects / Lopinavir - therapeutic use / Male / Middle Aged / Middle East respiratory syndrome / Original / Oxygen / Pandemics / Patient Acuity / Patients / Pneumonia / Pneumonia, Viral - drug therapy / Pneumonia, Viral - mortality / Pneumonia, Viral - virology / Proportional Hazards Models / Respiratory diseases / Reverse Transcriptase Polymerase Chain Reaction / Ribonucleic acid / Ritonavir / Ritonavir - adverse effects / Ritonavir - therapeutic use / RNA / SARS-CoV-2 / Severe acute respiratory syndrome coronavirus 2 / Time-to-Treatment / Treatment Failure / Viral Load

2020

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2020

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2020

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Journal Article

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

Guo, Li,

Zhang, Dingyu,

Qu, Zhaohui,

Peng, Lu,

Li, Kunxia,

Jaki, Thomas,

Ruan, Shunan,

Hayden, Frederick G,

Chen, Nanshan,

He, Jing,

Shang, Lianhan,

Zou, Jun,

Xie, Xuelei,

Wu, Xudong,

Bai, Tao,

Li, Caihong,

Wang, Shuzhen,

Zhan, Haiyan,

Song, Bin,

Wang, Yeming,

Yuan, Ye,

Wang, Ke,

Xiang, Jie,

Ge, Qin,

Fan, Guohui,

Dong, Xuan,

Liu, Ying,

Wang, Jingli,

Zhou, Xia,

Lu, Sixia,

Xia, Jiaan,

Xu, Jiuyang,

Li, Huadong,

Zhou, Fei,

Liu, Wen,

Luo, Shanshan,

Yu, Ting,

Hu, Xujuan,

Gong, Fengyun,

Zhang, Yi,

Cheng, Fang,

Huang, Chaolin,

Wei, Yuan,

Huang, Hanping,

Pan, Lihong,

Chen, Hua,

Jia, Chunmin,

Gu, Xiaoying,

Dong, Chongya,

Wei, Ming,

Zhang, Li,

Liu, Zhibo,

Li, Hui,

Ruan, Lianguo,

Wang, Juan,

Liu, Xia,

Wu, Jing,

Qiu, Fang,

Wen, Danning,

Tu, Shengjing,

Cao, Bin,

Cai, Yanping,

Horby, Peter W,

Li, Xingwang,

Wang, Chen

2020

Overview

Investigators in China report the results of an open-label, randomized clinical trial of lopinavir–ritonavir for the treatment of Covid-19 in 199 infected adult patients. The primary end point was the time to clinical improvement.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Aged

/ Antiretroviral drugs

/ Antiviral Agents - adverse effects

/ Antiviral Agents - therapeutic use

/ Antiviral drugs

/ Betacoronavirus - genetics