Journal Article

Tumor pH-responsive metastable-phase manganese sulfide nanotheranostics for traceable hydrogen sulfide gas therapy primed chemodynamic therapy

Lei, Shan, Qu, Junle, He, Ting, Jiang, Chao, Qin, Xialing, Lin, Jing, Jiang, Dawei, Huang, Peng, Zhu, Wei-Guo

2020

Overview

Manganese-based nanomaterials have piqued great interest in cancer nanotheranostics, owing to their excellent physicochemical properties. Here we report a facile wet-chemical synthesis of size-controllable, biodegradable, and metastable γ-phase manganese sulfide nanotheranostics, which is employed for tumor pH-responsive traceable gas therapy primed chemodynamic therapy (CDT), using bovine serum albumin (BSA) as a biological template (The final product was denoted as MnS@BSA). The as-prepared MnS@BSA can be degraded in response to the mildly acidic tumor microenvironment, releasing hydrogen sulfide (H S) for gas therapy and manganese ions for magnetic resonance imaging (MRI) and CDT. experiments validated the pH-responsiveness of MnS@BSA at pH 6.8 and both H S gas and •OH radicals were detected during its degradation. experiments showed efficiently tumor turn-on -weighted MRI, significantly suppressed tumor growth and greatly prolonged survival of tumor-bearing mice following intravenous administration of MnS@BSA. Our findings indicated that MnS@BSA nanotheranostics hold great potential for traceable H S gas therapy primed CDT of cancer.

• Publisher: Ivyspring International Publisher Pty Ltd,Ivyspring International Publisher
• Subject: Animals / Antineoplastic Combined Chemotherapy Protocols - administration & dosage / Antineoplastic Combined Chemotherapy Protocols - pharmacology / Cancer / Cell Line, Tumor / Cell Survival - drug effects / Contrast agents / Gases / Gases - administration & dosage / Gases - pharmacology / Hydrogen / Hydrogen Sulfide - administration & dosage / Hydrogen Sulfide - pharmacology / Hydrogen-Ion Concentration - drug effects / Magnetic resonance imaging / Magnetic Resonance Imaging - methods / Manganese Compounds - administration & dosage / Manganese Compounds - chemistry / Manganese Compounds - pharmacology / Medical imaging / Mice / Nanoparticles / Nanoparticles - chemistry / Nanoparticles - therapeutic use / Neoplasms - diagnostic imaging / Neoplasms - therapy / Physicochemical properties / Research Paper / Serum Albumin, Bovine - administration & dosage / Serum Albumin, Bovine - chemistry / Serum Albumin, Bovine - pharmacology / Sulfides - administration & dosage / Sulfides - chemistry / Sulfides - pharmacology / Theranostic Nanomedicine - methods / Tumor Microenvironment - drug effects / Tumors