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诱导多能干细胞移植对急性心肌梗死小鼠Q-T间期的影响
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Journal Article
诱导多能干细胞移植对急性心肌梗死小鼠Q-T间期的影响
2011
Overview
目的探讨诱导多能干细胞（iPSc）移植对急性心肌梗死小鼠心脏Q-T间期的影响,并对移植的安全性、有效性进行初步评估。方法建立小鼠心肌梗死模型并将其随机分为急性心肌梗死组（AMI）,急性心肌梗死＋生理盐水组（AMI＋NS）,急性心肌梗死＋iPSc组（AMI＋iPSc）,急性心肌梗死＋成纤维细胞组（AMI＋Fb）,每组15只,同时取20只小鼠设为正常对照组（NCG）。分别于移植iPSc后5min及1、2、3周,应用BL-420生物机能系统检测小鼠体表心电图肢体Ⅱ导联Q-T间期的变化。移植后2周采用免疫组化染色检测各组小鼠心肌缝隙连接蛋白43（Cx-43）的表达,应用Image-ProPlus软件进行半定量分析。结果与AMI组和AMI＋Fb组比较,移植2周后AMI＋iPSc组小鼠体表心电图Ⅱ导联Q-T间期明显缩短,梗死心肌Cx-43表达明显增加（P〈0.05）,而前两组间比较差异无统计学意义。移植后3周与2周时呈现相似的变化趋势。结论 iPSc移植可明显缩短心肌梗死小鼠延长的Q-T间期,并使小鼠梗死心肌Cx-43的表达增加,而成纤维细胞移植的小鼠中则未出现此现象。
