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The permeation of substances into cholesterol gallstones and the effect of deoxycholate on biliary immunoglobulin G concentration studies on gallstone pathogenesis in man and swine
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The permeation of substances into cholesterol gallstones and the effect of deoxycholate on biliary immunoglobulin G concentration studies on gallstone pathogenesis in man and swine
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The permeation of substances into cholesterol gallstones and the effect of deoxycholate on biliary immunoglobulin G concentration studies on gallstone pathogenesis in man and swine
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Dissertation
The permeation of substances into cholesterol gallstones and the effect of deoxycholate on biliary immunoglobulin G concentration studies on gallstone pathogenesis in man and swine
1994
Overview
IgG and mucous glycoprotein are proteins that accelerate nucleation of cholesterol crystals from bile. A relative increase in biliary deoxycholate level appears to be a risk factor for cholesterol gallstone formation. To determine the relationship between deoxycholate and IgG, glyco and tauro conjugated deoxycholates were measured in human gallbladder bile. Cholesterol gallstone patients had a higher concentration of biliary IgG compared to the pigmented stone group and control patients and this appeared to be associated with the simultaneous presence of two conditions: supersaturated bile with cholesterol and high deoxycholate/cholate ratio. To support this observation, animal studies were performed to determine whether a shift in bile salt profile toward deoxycholate plus changes in the cholesterol saturation had an effect on the secretion of IgG by porcine gallbladder epithelium. Cholesterol supersaturated model bile with high content of TDC produces gallbladder epithelial alterations which increase the concentration of intraluminal IgG and mucous glycoprotein. Experimental data supports the observation that both, increased relative proportion of deoxycholates and cholesterol supersaturation of gallbladder bile, results in higher concentration of the potent nucleator IgG in man.
