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8463 Immunophenotypes of T21 patients in the East of England
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Journal Article
8463 Immunophenotypes of T21 patients in the East of England
2025
Overview
Why did you do this work?A variety of immunological issues can be seen in patients with Trisomy 21 (T21), and they can require varying degrees of immunological support and intervention.We wanted to evaluate the immunophenotypes of the T21 patients we are caring for in our East of England Paediatric Immunology service order to understand our Immunology T21 cohort and future plan for optimisation of the care we provide to T21 patients from across the region.What did you do?The patients with T21 seen by our service are referred in from external clinicians, referred from an internal sub-specialty as an outpatient, or referred from an internal sub-specialty as an acutely unwell inpatient. There are no direct T21/Paediatric Immunology pathways and there is no sub-specialty T21 Paediatric Immunology Clinic.We looked back at the T21 patients seen in our Paediatric Immunology Clinic over a two-year period (September 2022 – September 2024) in order to better understand the immunology needs of our patient cohort.We looked at the demographics of the patients seen, their pathway into the service, their immunology test results, and type of input they required from us.What did you find?Patients with T21 can have a variety of immunological abnormalities, including decreased B cell numbers, decreased antibody responses, decreased T cell numbers, decreased T cell proliferation in response to mitogens, and impaired phagocyte function. We collated the immunological test results of our T21 patients to describe the immunophenotypes seen in our cohort.We described the pathways by which the patients reached our service and the amount of input (in particular, but not limited to, regarding medications) required by our service.What does it mean?To provide the highest quality care for this group of patients we want to continuously improve the service we deliver, we want to optimise their access to the immunological input they might need, and we want to avoid them receiving delayed care.We will use our evaluation of the current Paediatric Immunology T21 cohort to inform improvement of our service and our support of this patient group and their families.
Publisher
BMJ Publishing Group LTD
Subject
