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Production and in vivo PET/CT imaging of the theranostic pair 132/135 La
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Production and in vivo PET/CT imaging of the theranostic pair 132/135 La
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Production and in vivo PET/CT imaging of the theranostic pair 132/135 La
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Journal Article
Production and in vivo PET/CT imaging of the theranostic pair 132/135 La
2019
Overview
The present study describes a novel method for the low energy cyclotron production and radiochemical isolation of no-carrier-added
La
from bulk
Ba. This separation strategy combines precipitation and single-column extraction chromatography to afford an overall radiochemical yield (92 ± 2%) and apparent molar activity (22 ± 4 Mbq/nmol) suitable for the radiolabeling of DOTA-conjugated vectors. The produced
La
has a radiochemical and radionuclidic purity amenable for
La/
La-based cancer theranostic applications. Longitudinal PET/CT images acquired using the positron-emitting
La and ex vivo biodistribution data separately corroborated the accumulation of unchelated
La
ions in bone and the liver.
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