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International management and Intercultural Communication consists of cases of direct observation and personal involvement in a wide variety of communication challenges in international management settings, and discusses them in terms of management theories. The cases explore interactions across national cultures and regional boundaries, demonstrating both traditional and unusual approaches to problems that sooner or later are likely to challenge all managers who operate internationally. The book is presented in two volumes. Volume 1 contains case studies concerning different aspects of international management and intercultural communication in business, marketing and policies. -- from back cover of Volume 1.

From a historical perspective and a uniquely cross-disciplinary approach, Elizabeth Christopher identifies the major leadership styles that continue to characterise people across regions, nations, communities and organisations, within groups and as individuals. She provides a practical and comprehensive textbook for successful negotiation in a world rich not only in cultural diversity but also in convergence.

With his Letter of 1493 to the court of Spain, Christopher Columbus heralded his first voyage to the present-day Americas, creating visions that seduced the European imagination and birthing a fascination with those \"new\" lands and their inhabitants that continues today. Columbus's epistolary announcement travelled from country to country in a late-medieval media event -- and the rest, as has been observed, is history. The Letter has long been the object of speculation concerning its authorship and intention: British historian Cecil Jane questions whether Columbus could read and write prior to the first voyage while Demetrio Ramos argues that King Ferdinand and a minister composed the Letter and had it printed in the Spanish folio. The Letter has figured in studies of Spanish Imperialism and of Discovery and Colonial period history, but it also offers insights into Columbus's passions and motives as he reinvents himself and retails his vision of Peter Martyr's Novus orbis to men and women for whom Columbus was as unknown as the places he claimed to have visited. The central feature of the book is its annotated variorum edition of the Spanish Letter, together with an annotated English translation and word and name glossaries. A list of terms from early print-period and manuscript cultures supports those critical discussions. In the context of her text-based reading, the author addresses earlier critical perspectives on the Letter, explores foundational questions about its composition, publication and aims, and proposes a theory of authorship grounded in text, linguistics, discourse, and culture.

Several plant products have been tested and found to possess antileishmanial activity. The present study was undertaken to establish whether methanolic extract of Allium sativum Linn has antileishmanial activity in comparison to standard drugs. Methanolic extract of A. sativum bulbs was screened for in vitro and in vivo antileishmanial activity against Leishmania major strain (NLB 145) and L. donovani strain (NLB 065). Pentostam and Amphotericin B were used as standard drugs. BALB/c mice and golden hamsters (Mesocricetus auratus) were used in in vivo studies on L. major and L. donovani respectively. The extract exhibited very low cytotoxicity (IC50 >450 μg/ml) against Vero cells. The extract had significantly better (p <0.001) leishmanicidal activity against both species (IC50 34.22 μg/ml to L. major, 37.41 μg/ml to L. donovani) than Pentostam. However, the activity was significantly lower (p <0.001) than that of Amphotericin B against both the species. At a concentration of 250 μg/ml, the extract induced the production of 60 μM of nitric oxide, a ten-fold up-regulation in activated macrophages. The multiplication indices for L. major amastigotes treated in 100 μg/ml were significantly different (p <0.05). Treatment with the extract, daily for 28 days led to a significant reduction (p <0.05) in footpad swelling in BALB/c mice; similar activity noticed in the treatment with standard drugs. The Leishman-Donovan Units (LDU) for the extract treated animals were significantly higher (p <0.05) than those of standard drugs, but lower compared to the negative control. Since the mechanism of action for the methanolic extract is apparently immunomodulatory, garlic compounds could be purified and tried as complementary medicine in the management of leishmaniases.

\"To Love the Wind and the Rain\" is a groundbreaking and vivid analysis of the relationship between African Americans and the environment in U.S. history. It focuses on three major themes: African Americans in the rural environment, African Americans in the urban and suburban environments, and African Americans and the notion of environmental justice. Meticulously researched, the essays cover subjects including slavery, hunting, gardening, religion, the turpentine industry, outdoor recreation, women, and politics. \"To Love the Wind and the Rain\" will serve as an excellent foundation for future studies in African American environmental history.

During the past 10 years, multidrug-resistant Gram-negative Enterobacteriaceae have become a substantial challenge to infection control. It has been suggested by clinicians that the effectiveness of antibiotics is in such rapid decline that, depending on the pathogen concerned, their future utility can be measured in decades or even years. Unless the rise in antibiotic resistance can be reversed, we can expect to see a substantial rise in incurable infection and fatality in both developed and developing regions. Antibiotic resistance develops through complex interactions, with resistance arising by de-novo mutation under clinical antibiotic selection or frequently by acquisition of mobile genes that have evolved over time in bacteria in the environment. The reservoir of resistance genes in the environment is due to a mix of naturally occurring resistance and those present in animal and human waste and the selective effects of pollutants, which can co-select for mobile genetic elements carrying multiple resistant genes. Less attention has been given to how anthropogenic activity might be causing evolution of antibiotic resistance in the environment. Although the economics of the pharmaceutical industry continue to restrict investment in novel biomedical responses, action must be taken to avoid the conjunction of factors that promote evolution and spread of antibiotic resistance.

In a randomized trial involving patients with paroxysmal atrial fibrillation, pulsed field ablation was noninferior to thermal ablation with respect to freedom from a composite of procedural and arrhythmia events at 1 year.

In the primary analysis of CheckMate 9ER, nivolumab plus cabozantinib showed superior progression-free survival, overall survival, and objective response over sunitinib in patients with previously untreated advanced renal cell carcinoma (median follow-up of 18·1 months). Here, we report extended follow-up of overall survival and updated efficacy and safety. This open-label, randomised, phase 3 trial was done in 125 hospitals and cancer centres across 18 countries. We included patients aged 18 years or older with previously untreated advanced or metastatic clear-cell renal cell carcinoma, a Karnofsky performance status of 70% or higher, measurable disease according to Response Evaluation Criteria in Solid Tumors version 1.1 assessed by the investigator, any International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) prognostic risk category, and available tumour tissue for PD-L1 testing. Patients were randomly assigned (1:1) to nivolumab (240 mg) intravenously every 2 weeks plus cabozantinib (40 mg) orally once daily or sunitinib (50 mg orally) once daily (4 weeks per 6-week cycle). Randomisation, stratified by IMDC risk status, tumour PD-L1 expression, and geographical region, was done by permuted block within each stratum using a block size of four, via an interactive response system. The primary endpoint was progression-free survival by blinded independent central review. Overall survival was a secondary endpoint (reported here as the preplanned final analysis according to the protocol). Efficacy was assessed in all randomly assigned patients; safety was assessed in all patients who received at least one dose of any study drug. This ongoing study, closed to recruitment, is registered with ClinicalTrials.gov, NCT03141177. Between Sept 11, 2017, and May 14, 2019, 323 patients were randomly assigned to the nivolumab plus cabozantinib group and 328 to the sunitinib group. With an extended follow-up (data cutoff of June 24, 2021; median 32·9 months [IQR 30·4–35·9]), median overall survival was 37·7 months (95% CI 35·5–not estimable) in the nivolumab plus cabozantinib group and 34·3 months (29·0–not estimable) in the sunitinib group (hazard ratio [HR] 0·70 [95% CI 0·55–0·90], p=0·0043) and updated median progression-free survival was 16·6 months (12·8–19·8) versus 8·3 months (7·0–9·7; HR 0·56 [95% CI 0·46−0·68], p<0·0001). Grade 3–4 treatment-related adverse events occurred in 208 (65%) of 320 patients with nivolumab plus cabozantinib versus 172 (54%) of 320 with sunitinib. The most common grade 3–4 treatment-related adverse events were hypertension (40 [13%] of 320 patients in the nivolumab plus cabozantinib group vs 39 [12%] of 320 in the sunitinib group), palmar–plantar erythrodysaesthesia (25 [8%] vs 26 [8%]), and diarrhoea (22 [7%] vs 15 [5%]). Grade 3–4 treatment-related serious adverse events occurred in 70 (22%) of 320 patients in the nivolumab plus cabozantinib group and 31 (10%) of 320 in the sunitinib group. One additional treatment-related death occurred with sunitinib (sudden death). With extended follow-up and preplanned final overall survival analysis per protocol, nivolumab plus cabozantinib demonstrated improved efficacy versus sunitinib, further supporting the combination in the first-line treatment of advanced renal cell carcinoma. Bristol Myers Squibb and Ono Pharmaceutical.