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The neuroscientist who lost her mind : my tale of madness and recovery
As a deadly cancer spread inside her brain, neuroscientist Barbara Lipska was plunged into madness--only to miraculously survive with her memories intact. In the tradition of \"My Stroke of Insight\" and \"Brain on Fire,\" this memoir recounts her ordeal and explains its unforgettable lessons about the brain and mind.
Book
A series of catastrophes & miracles : a true story of love, science, and cancer
\"After being diagnosed in her early 40s with metastatic melanoma--a 'rapidly fatal' form of cancer--journalist and mother of two Mary Elizabeth Williams finds herself in a race against the clock. She takes a once-in-a-lifetime chance and joins a clinical trial for immunotherapy, a revolutionary drug regimen that trains the body to vanquish malignant cells. Astonishingly, her cancer disappears entirely in just a few weeks. But at the same time, her best friend embarks on a cancer journey of her own--with very different results\"-- Provided by publisher.
Book
Author Correction: A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1alpha activation, tumorigenesis and metastasis
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Journal Article
Enhanced axillary assessment using intradermally injected microbubbles and contrast-enhanced ultrasound identifies axillary disease missed by conventional B-mode ultrasound that may be clinically relevant
Purpose The purpose of this study is to measure pre-treatment diagnostic yield of malignant lymph nodes (LN) using contrast-enhanced ultrasound (CEUS) in addition to B-mode axillary ultrasound and compare clinicopathological features, response to NACT and long-term outcomes of patients with malignant LN detected with B-mode ultrasound versus CEUS. Methods Between August 2009 and October 2016, NACT patients were identified from a prospective database. Follow-up data were collected until May 2019. Results 288 consecutive NACT patients were identified; 77 were excluded, 110 had malignant LN identified by B-mode ultrasound (Group A) and 101 patients with negative B-mode axillary ultrasound had CEUS with biopsy of sentinel lymph nodes (SLN). In two cases CEUS failed. Malignant SLN were identified in 35/99 (35%) of B-mode ultrasound-negative cases (Group B). Patients in Group A were similar to those in Group B in age, mean diagnostic tumour size, grade and oestrogen receptor status. More Group A patients had a ductal phenotype. In the breast, 34 (31%) Group A patients and 8 (23%) Group B patients achieved a pathological complete response (PCR). In the axilla, 41 (37%) and 13 (37%) Groups A and B patients, respectively, had LN PCR. The systemic relapse rate was not statistically different (5% and 16% for Groups A and B, respectively). Conclusions Enhanced assessment with CEUS before NACT identifies patients with axillary metastases missed by conventional B-mode ultrasound. Without CEUS, 22 (63%) of cases in Group B (negative B-mode ultrasound) may have been erroneously classed as progressive disease by surgical SLN excision after NACT.
Journal Article
Rare axillary cancer of unknown primary originating from the breast of a 64-year-old male patient: A case report and literature review
Cancers of unknown primary (CUPs) are a heterogeneous group of tumors characterized by a difficult diagnosis. The primitive tumor remains unknown, whereas metastases are the most common manifestation. Occult male breast cancers are very rare types of CUPs. The present study describes the case of a 64-year-old man affected by a CUP of presumed mammary origin. The aim of the article and the present review was to focus on their management. To the best of our knowledge, only thirteen cases have been reported in the literature. Because no specific guidelines are available, various approaches have been applied, influencing the treatment and the prognosis of patients with CUP. Key words: male breast cancer, occult male breast cancer, male breast cancer of unknown primary
Journal Article