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The Responsibility to Protect: Ending Mass Atrocity Crimes Once and For All
After the Holocaust, the world vowed it would never again stand by and permit such heinous crimes against humanity. Yet many subsequent atrocities have gone unchecked, all over the world: from the killing fields of Cambodia, to Rwanda, and to Srebrenica. The bloody list continues to grow, led by the unfolding nightmare in Darfur. How and why were the world's best intentions derailed, and what can be done today to put these efforts back on track? The \"responsibility to protect: - R2P for short - was unanimously embraced at the UN World Summit in 2005. The heart of this new international norm is the belief that if sovereign governments fail to protect their own people from mass atrocity crimes, then responsibility shifts to the wider international community to take whatever action is appropriate, including (in extreme cases) the use of force. The world cannot, and will not, just stand by. Evens spells out the steps needed to make R2P work in practice and clarifies the misunderstandings, real or contrived, which persist about its scope and limits. He emphasizes the need for preventive action, and for preferring assistance and persuasion to coercion, but he also makes clear when it is right to fight. The book is enlivened throughout by real world examples, analyses of current events, and assessments drawn from the author's own vast experience.
eBook
Terrorism, radicalisation & countering violent extremism : practical considerations & concerns
This text brings together research that covers perspectives and case studies on terrorism, radicalisation and countering violent extremism (CVE). Written by experts involved in these issues at the grassroots, it bridges the academic-practitioner gap in the field. The proliferation of academic studies and conferences devoted to these subjects has meant that policymakers and practitioners in the same fields sometimes struggle to digest the sheer volume of academic output. The same critical questions keep coming up, but it is debatable the level to which there have been tangible improvements to our real state of knowledge: knowledge in especially in terms of what 'best practices' exist in the field (and what can be translated, versus what approaches remain context and location specific).
Book
Four year efficacy of prophylactic human papillomavirus quadrivalent vaccine against low grade cervical, vulvar, and vaginal intraepithelial neoplasia and anogenital warts: randomised controlled trial
Objectives To evaluate the prophylactic efficacy of the human papillomavirus (HPV) quadrivalent vaccine in preventing low grade cervical, vulvar, and vaginal intraepithelial neoplasias and anogenital warts (condyloma acuminata).Design Data from two international, double blind, placebo controlled, randomised efficacy trials of quadrivalent HPV vaccine (protocol 013 (FUTURE I) and protocol 015 (FUTURE II)). The trials were to be 4 years in length, and the results reported are from final study data of 42 months’ follow-up.Setting Primary care centres and university or hospital associated health centres in 24 countries and territories around the world.Participants 17 622 women aged 16-26 years enrolled between December 2001 and May 2003. Major exclusion criteria were lifetime number of sexual partners (>4), history of abnormal cervical smear test results, and pregnancy.Intervention Three doses of quadrivalent HPV vaccine (for serotypes 6, 11, 16, and 18) or placebo at day 1, month 2, and month 6.Main outcome measures Vaccine efficacy against cervical, vulvar, and vaginal intraepithelial neoplasia grade I and condyloma in a per protocol susceptible population that included subjects who received all three vaccine doses, tested negative for the relevant vaccine HPV types at day 1 and remained negative through month 7, and had no major protocol violations. Intention to treat, generally HPV naive, and unrestricted susceptible populations were also studied.Results In the per protocol susceptible population, vaccine efficacy against lesions related to the HPV types in the vaccine was 96% for cervical intraepithelial neoplasia grade I (95% confidence interval 91% to 98%), 100% for both vulvar and vaginal intraepithelial neoplasia grade I (95% CIs 74% to 100%, 64% to 100% respectively), and 99% for condyloma (96% to 100%). Vaccine efficacy against any lesion (regardless of HPV type) in the generally naive population was 30% (17% to 41%), 75% (22% to 94%), and 48% (10% to 71%) for cervical, vulvar, and vaginal intraepithelial neoplasia grade I, respectively, and 83% (74% to 89%) for condyloma.Conclusions Quadrivalent HPV vaccine provided sustained protection against low grade lesions attributable to vaccine HPV types (6, 11, 16, and 18) and a substantial reduction in the burden of these diseases through 42 months of follow-up.Trial registrations NCT00092521 and NCT00092534.
Journal Article
New approaches to countering terrorism : designing and evaluating counter radicalization and de-radicalization programs
Hamed El-Said investigates the emergence of new, 'soft' approaches to counter violent extremists, generally known as counter radicalization and deradicalization programmes (Counter-de-Rad). This is the first work to develop a holistic framework which will allow policy makers and practitioners to better understand conditions conducive to violent extremism, and to better design and effectively implement such programmes in the future. This book, supported and facilitated by a wealth of primary research and consideration of all stakeholders, addresses cultural and legal differences between countries while developing its holistic approach. In addition, the research focuses on and identifies conditions conducive to either the success or the failure of Counter-de-Rad programmes. Finally, it provides a new, broader approach to evaluate the performance of such programmes, one that goes beyond the current narrow models which treat recidivism rates as the main indicator of success or failure.
Book
Saving Children from a Life of Crime
After decades of rigorous study in the United States and across the Western world, a great deal is known about the early risk factors for offending. High impulsiveness, low attainment, criminal parents, parental conflict, and growing up in a deprived, high-crime neighborhood are among the most important factors. There is also a growing body of high quality scientific evidence on the effectiveness of early prevention programs designed to prevent children from embarking on a life of crime. Drawing on the latest evidence, this is the first book to assess the early causes of offending and what works best to prevent it. Preschool intellectual enrichment, child skills training, parent management training, and home visiting programs are among the most effective early prevention programs. The authors of this book, who are both criminologists, outline a policy strategy—early prevention—that uses this current research knowledge and brings into sharper focus what America's national crime fighting priority ought to be. At a time when unacceptable crime levels in America, rising criminal justice costs, and a punitive crime policy have spurred a growing interest in the early prevention of delinquency, the book lays the groundwork for change with a comprehensive national prevention strategy to save children from a life of crime.
eBook
2019 update of EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases
To update the European League Against Rheumatism (EULAR) recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD) published in 2011. Four systematic literature reviews were performed regarding the incidence/prevalence of vaccine-preventable infections among patients with AIIRD; efficacy, immunogenicity and safety of vaccines; effect of anti-rheumatic drugs on the response to vaccines; effect of vaccination of household of AIIRDs patients. Subsequently, recommendations were formulated based on the evidence and expert opinion. The updated recommendations comprise six overarching principles and nine recommendations. The former address the need for an annual vaccination status assessment, shared decision-making and timing of vaccination, favouring vaccination during quiescent disease, preferably prior to the initiation of immunosuppression. Non-live vaccines can be safely provided to AIIRD patients regardless of underlying therapy, whereas live-attenuated vaccines may be considered with caution. Influenza and pneumococcal vaccination should be strongly considered for the majority of patients with AIIRD. Tetanus toxoid and human papilloma virus vaccination should be provided to AIIRD patients as recommended for the general population. Hepatitis A, hepatitis B and herpes zoster vaccination should be administered to AIIRD patients at risk. Immunocompetent household members of patients with AIIRD should receive vaccines according to national guidelines, except for the oral poliomyelitis vaccine. Live-attenuated vaccines should be avoided during the first 6 months of life in newborns of mothers treated with biologics during the second half of pregnancy. These 2019 EULAR recommendations provide an up-to-date guidance on the management of vaccinations in patients with AIIRD.
Journal Article
Guidelines for preventing opportunistic infections among HIV-infected persons-2002: Recommendations of the U.S. public Health Service and the infectious Diseases Society of America
In 1995, the U.S. Public Health Service (USPHS) and the Infectious Diseases Society of America (IDSA) developed guidelines for preventing opportunistic infections (OIs) among persons infected with human immunodeficiency virus (HIV); these guidelines were updated in 1997 and 1999. This fourth edition of the guidelines, made available on the Internet in 2001, is intended for clinicians and other health-care providers who care for HIV-infected persons. The goal of these guidelines is to provide evidence-based guidelines for preventing OIs among HIV-infected adults and adolescents, including pregnant women, and HIV-exposed or infected children. Nineteen OIs, or groups of OIs, are addressed, and recommendations are included for preventing exposure to opportunistic pathogens, preventing first episodes of disease by chemoprophylaxis or vaccination (primary prophylaxis), and preventing disease recurrence (secondary prophylaxis). Major changes since the last edition of the guidelines include 1) updated recommendations for discontinuing primary and secondary OI prophylaxis among persons whose CD4+ T lymphocyte counts have increased in response to antiretroviral therapy; 2) emphasis on screening all HIV-infected persons for infection with hepatitis C virus; 3) new information regarding transmission of human herpesvirus 8 infection; 4) new information regarding drug interactions, chiefly related to rifamycins and antiretroviral drugs; and 5) revised recommendations for immunizing HIV-infected adults and adolescents and HIV-exposed or infected children.
Journal Article