تفاصيل الأصول
MbrlCatalogueTitleDetail
هل ترغب في حجز الكتاب؟
The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis
بواسطة
Hartley, Rebecca S
, Wise, Helen M
, Almeida, Alexandra D
, Philpott, Anna
, Hindley, Christopher J
, Slevin, Michael K
في
Animals
/ Blotting, Western
/ Cell cycle
/ Cell Differentiation - genetics
/ Cell division
/ Cell Proliferation
/ Colleges & universities
/ Cyclin E - metabolism
/ Cyclin-dependent kinases
/ Design
/ DNA, Complementary
/ Embryonic development
/ Enzymes
/ F-Box Proteins - genetics
/ F-Box Proteins - metabolism
/ F-Box-WD Repeat-Containing Protein 7
/ Gene Expression Regulation, Developmental
/ Genetic aspects
/ Genetic engineering
/ Genomes
/ Health sciences
/ In Situ Hybridization
/ Kinases
/ Microinjections
/ Neural crest
/ Neural Crest - embryology
/ Neural Crest - metabolism
/ Physiological aspects
/ Plasmids - genetics
/ Point Mutation
/ Polymerase Chain Reaction
/ Protein Isoforms - metabolism
/ Proteins
/ Research article
/ RNA, Messenger
/ Sequence Deletion
/ Ubiquitin - genetics
/ Ubiquitin-proteasome system
/ Xenopus laevis - embryology
/ Xenopus laevis - genetics
/ Xenopus laevis - metabolism
/ Xenopus Proteins - genetics
/ Xenopus Proteins - metabolism
2010
لقد وضعنا الحجز لك!
بالمناسبة ، لماذا لا تستكشف الفعاليات التي يمكنك حضورها عند زيارتك للمكتبة لإستلام كتبك
أنت حاليًا في قائمة الانتظار لالتقاط هذا الكتاب. سيتم إخطارك بمجرد انتهاء دورك في التقاط الكتاب
هل أنت متأكد أنك تريد إزالة الكتاب من الرف؟
The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis
بواسطة
Hartley, Rebecca S
, Wise, Helen M
, Almeida, Alexandra D
, Philpott, Anna
, Hindley, Christopher J
, Slevin, Michael K
في
Animals
/ Blotting, Western
/ Cell cycle
/ Cell Differentiation - genetics
/ Cell division
/ Cell Proliferation
/ Colleges & universities
/ Cyclin E - metabolism
/ Cyclin-dependent kinases
/ Design
/ DNA, Complementary
/ Embryonic development
/ Enzymes
/ F-Box Proteins - genetics
/ F-Box Proteins - metabolism
/ F-Box-WD Repeat-Containing Protein 7
/ Gene Expression Regulation, Developmental
/ Genetic aspects
/ Genetic engineering
/ Genomes
/ Health sciences
/ In Situ Hybridization
/ Kinases
/ Microinjections
/ Neural crest
/ Neural Crest - embryology
/ Neural Crest - metabolism
/ Physiological aspects
/ Plasmids - genetics
/ Point Mutation
/ Polymerase Chain Reaction
/ Protein Isoforms - metabolism
/ Proteins
/ Research article
/ RNA, Messenger
/ Sequence Deletion
/ Ubiquitin - genetics
/ Ubiquitin-proteasome system
/ Xenopus laevis - embryology
/ Xenopus laevis - genetics
/ Xenopus laevis - metabolism
/ Xenopus Proteins - genetics
/ Xenopus Proteins - metabolism
2010
وجه الفتاة! هناك خطأ ما.
أثناء محاولة إزالة العنوان من الرف ، حدث خطأ ما :( يرجى إعادة المحاولة لاحقًا!
وجه الفتاة! هناك خطأ ما.
أثناء محاولة إضافة العنوان إلى الرف ، حدث خطأ ما :( يرجى إعادة المحاولة لاحقًا!
هل تريد طلب الكتاب؟
The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis
بواسطة
Hartley, Rebecca S
, Wise, Helen M
, Almeida, Alexandra D
, Philpott, Anna
, Hindley, Christopher J
, Slevin, Michael K
في
Animals
/ Blotting, Western
/ Cell cycle
/ Cell Differentiation - genetics
/ Cell division
/ Cell Proliferation
/ Colleges & universities
/ Cyclin E - metabolism
/ Cyclin-dependent kinases
/ Design
/ DNA, Complementary
/ Embryonic development
/ Enzymes
/ F-Box Proteins - genetics
/ F-Box Proteins - metabolism
/ F-Box-WD Repeat-Containing Protein 7
/ Gene Expression Regulation, Developmental
/ Genetic aspects
/ Genetic engineering
/ Genomes
/ Health sciences
/ In Situ Hybridization
/ Kinases
/ Microinjections
/ Neural crest
/ Neural Crest - embryology
/ Neural Crest - metabolism
/ Physiological aspects
/ Plasmids - genetics
/ Point Mutation
/ Polymerase Chain Reaction
/ Protein Isoforms - metabolism
/ Proteins
/ Research article
/ RNA, Messenger
/ Sequence Deletion
/ Ubiquitin - genetics
/ Ubiquitin-proteasome system
/ Xenopus laevis - embryology
/ Xenopus laevis - genetics
/ Xenopus laevis - metabolism
/ Xenopus Proteins - genetics
/ Xenopus Proteins - metabolism
2010
يرجى العلم أن الكتاب الذي طلبته لا يمكن استعارته. إذا كنت ترغب في إستعارة هذا الكتاب ، يمكنك حجز نسخة أخرى
The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis
Journal Article
The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis
2010
اطلب الآن
واختر طريقة الاستلام
نظرة عامة
The neural crest is a unique population of cells that arise in the vertebrate ectoderm at the neural plate border after which they migrate extensively throughout the embryo, giving rise to a wide range of derivatives. A number of proteins involved in neural crest development have dynamic expression patterns, and it is becoming clear that ubiquitin-mediated protein degradation is partly responsible for this.
Here we demonstrate a novel role for the F-box protein Cdc4/Fbxw7 in neural crest development. Two isoforms of Xenopus laevis Cdc4 were identified, and designated xCdc4alpha and xCdc4beta. These are highly conserved with vertebrate Cdc4 orthologs, and the Xenopus proteins are functionally equivalent in terms of their ability to degrade Cyclin E, an established vertebrate Cdc4 target. Blocking xCdc4 function specifically inhibited neural crest development at an early stage, prior to expression of c-Myc, Snail2 and Snail.
We demonstrate that Cdc4, an ubiquitin E3 ligase subunit previously identified as targeting primarily cell cycle regulators for proteolysis, has additional roles in control of formation of the neural crest. Hence, we identify Cdc4 as a protein with separable but complementary functions in control of cell proliferation and differentiation.
الناشر
BioMed Central Ltd,BioMed Central,BMC
يستخدم هذا الموقع ملفات تعريف الارتباط لضمان حصولك على أفضل تجربة على موقعنا.