تفاصيل الأصول
MbrlCatalogueTitleDetail
هل ترغب في حجز الكتاب؟
Three-dimensional collagen represses cyclin E1 via beta1 integrin in invasive breast cancer cells
بواسطة
Wu, Yuehan
, Brandt, Yekaterina
, Hartley, Rebecca S
, Guo, Xun
, Hathaway, Helen J
في
Breast cancer
/ Cancer cells
/ Cellular biology
/ Collagen
/ Development and progression
/ Genetic transcription
/ Integrins
/ Phosphotransferases
/ Protein binding
/ RNA
/ Toy industry
2011
لقد وضعنا الحجز لك!
بالمناسبة ، لماذا لا تستكشف الفعاليات التي يمكنك حضورها عند زيارتك للمكتبة لإستلام كتبك
أنت حاليًا في قائمة الانتظار لالتقاط هذا الكتاب. سيتم إخطارك بمجرد انتهاء دورك في التقاط الكتاب
هل أنت متأكد أنك تريد إزالة الكتاب من الرف؟
Three-dimensional collagen represses cyclin E1 via beta1 integrin in invasive breast cancer cells
بواسطة
Wu, Yuehan
, Brandt, Yekaterina
, Hartley, Rebecca S
, Guo, Xun
, Hathaway, Helen J
في
Breast cancer
/ Cancer cells
/ Cellular biology
/ Collagen
/ Development and progression
/ Genetic transcription
/ Integrins
/ Phosphotransferases
/ Protein binding
/ RNA
/ Toy industry
2011
وجه الفتاة! هناك خطأ ما.
أثناء محاولة إزالة العنوان من الرف ، حدث خطأ ما :( يرجى إعادة المحاولة لاحقًا!
وجه الفتاة! هناك خطأ ما.
أثناء محاولة إضافة العنوان إلى الرف ، حدث خطأ ما :( يرجى إعادة المحاولة لاحقًا!
هل تريد طلب الكتاب؟
Three-dimensional collagen represses cyclin E1 via beta1 integrin in invasive breast cancer cells
بواسطة
Wu, Yuehan
, Brandt, Yekaterina
, Hartley, Rebecca S
, Guo, Xun
, Hathaway, Helen J
في
Breast cancer
/ Cancer cells
/ Cellular biology
/ Collagen
/ Development and progression
/ Genetic transcription
/ Integrins
/ Phosphotransferases
/ Protein binding
/ RNA
/ Toy industry
2011
يرجى العلم أن الكتاب الذي طلبته لا يمكن استعارته. إذا كنت ترغب في إستعارة هذا الكتاب ، يمكنك حجز نسخة أخرى
Three-dimensional collagen represses cyclin E1 via beta1 integrin in invasive breast cancer cells
Journal Article
Three-dimensional collagen represses cyclin E1 via beta1 integrin in invasive breast cancer cells
2011
اطلب الآن
واختر طريقة الاستلام
نظرة عامة
The behavior of breast epithelial cells is influenced by their microenvironment which includes stromal cells and extracellular matrix (ECM). During cancer progression, the tissue microenvironment fails to control proliferation and differentiation, resulting in uncontrolled growth and invasion. Upon invasion, the ECM encountered by breast cancer cells changes from primarily laminin and collagen IV to primarily collagen I. We show here that culturing invasive breast cancer cells in 3-dimensional (3D) collagen I inhibits proliferation through direct regulation of cyclin E1, a [G.sub.1]/S regulator that is overexpressed in breast cancer. When the breast cancer cell line MDAMB-231 was cultured within 3D collagen I gels, the [G.sub.1]/S transition was inhibited as compared to cells cultured on conventional 2D collagen or plastic dishes. Cells in 3D collagen downregulated cyclin E1 protein and mRNA, with no change in cyclin D1 level. Cyclin D1 was primarily cytoplasmic in 3D cultures, and this was accompanied by decreased phosphorylation of Rb, a nuclear target for both cyclin E1- and cyclin D1-associated kinases. Positive regulators of cyclin E1 expression, the transcription factor c-Myc and cold-inducible RNA binding protein (CIRP), were decreased in 3D collagen cultures, while the collagen I receptor [beta]1 integrin was greatly increased. Inhibition of [beta]1 integrin function rescued proliferation and cyclin E1 expression as well as c-Myc expression and Rb phosphorylation, but cyclin D1 remained cytoplasmic. We conclude that cyclin E1 is repressed independent of effects on cyclin D1 in a 3D collagen environment and dependent on [beta]1 integrin interaction with collagen I, reducing proliferation of invasive breast cancer cells. Keywords 3-Dimensional collagen, Breast cancer, Cyclin E1, Cell cycle, [beta]1 Integrin
الناشر
Springer,Springer Nature B.V
يستخدم هذا الموقع ملفات تعريف الارتباط لضمان حصولك على أفضل تجربة على موقعنا.