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We investigate and model a method for producing entanglement between two spatially separated Bose-Einstein condensates (BECs). In our approach, a spin-polarized BEC is squeezed using a (Sz)2 interaction, then are split into two separate clouds. After the split, we consider that the particle number in each cloud collapses to a fixed number. We show that this procedure is equivalent to applying an interaction corresponding to squeezing each cloud individually plus an entangling operation. We analyze the system's inter-well entanglement properties and show that it can be detected using correlation-based entanglement criteria. The nature of the states is illustrated by Wigner functions and have the form of a correlated squeezed state. The conditional Wigner function shows high degrees of non-classicality for dimensionless squeezing times beyond 1 N , where N is the number of particles per BEC.

Nuclear condensates of m6A-methylated mRNAs with their ‘reader’ YTHDC1 prevent the degradation of acute myeloid leukaemia-promoting mRNAs by the exosome.

We report the structural transformation of the low-lying spectral modes, especially the Kohn mode, from radial to circular topology as harmonic confining potential is modified to a toroidal one, and this corresponds to a transition from simply to multiply connected geometry. For this we employ the Hartree-Fock-Bogoliubov theory to examine the evolution of low energy quasiparticles. We, then, use the Hartree-Fock-Bogoliubov theory with the Popov approximation to demonstrate the two striking features of quantum and thermal fluctuations. At T = 0, the non-condensate density due to interaction induced quantum fluctuations increases with the transformation from pancake to toroidal geometry. The other feature is, there is a marked change in the density profile of the non-condensate density at finite temperatures with the modification of trapping potential. In particular, the condensate and non-condensate density distributions have overlapping maxima in the toroidal condensate, which is in stark contrast to the case of pancake geometry. The genesis of this difference lies in the nature of the thermal fluctuations.

Biomolecular condensates have been implicated in multiple cellular processes. However, the global role played by condensates in 3D chromatin organization remains unclear. At present, 1,6-hexanediol (1,6-HD) is the only available tool to globally disrupt condensates, yet the conditions of 1,6-HD vary considerably between studies and may even trigger apoptosis. In this study, we first analyzed the effects of different concentrations and treatment durations of 1,6-HD and found that short-term exposure to 1.5% 1,6-HD dissolved biomolecular condensates whereas long-term exposure caused aberrant aggregation without affecting cell viability. Based on this condition, we drew a time-resolved map of 3D chromatin organization and found that short-term treatment with 1.5% 1,6-HD resulted in reduced long-range interactions, strengthened compartmentalization, homogenized A-A interactions, B-to-A compartment switch and TAD reorganization, whereas longer exposure had the opposite effects. Furthermore, the long-range interactions between condensate-component-enriched regions were markedly weakened following 1,6-HD treatment. In conclusion, our study finds a proper 1,6-HD condition and provides a resource for exploring the role of biomolecular condensates in 3D chromatin organization.

Owing to the low-gravity conditions in space, space-borne laboratories enable experiments with extended free-fall times. Because Bose-Einstein condensates have an extremely low expansion energy, space-borne atom interferometers based on Bose-Einstein condensation have the potential to have much greater sensitivity to inertial forces than do similar ground-based interferometers. On 23 January 2017, as part of the sounding-rocket mission MAIUS-1, we created Bose-Einstein condensates in space and conducted 110 experiments central to matter-wave interferometry, including laser cooling and trapping of atoms in the presence of the large accelerations experienced during launch. Here we report on experiments conducted during the six minutes of in-space flight in which we studied the phase transition from a thermal ensemble to a Bose-Einstein condensate and the collective dynamics of the resulting condensate. Our results provide insights into conducting cold-atom experiments in space, such as precision interferometry, and pave the way to miniaturizing cold-atom and photon-based quantum information concepts for satellite-based implementation. In addition, space-borne Bose-Einstein condensation opens up the possibility of quantum gas experiments in low-gravity conditions .

Quantum droplets are small clusters of atoms self-bound by the balance of attractive and repulsive forces. Here, we report on the observation of droplets solely stabilized by contact interactions in a mixture of two Bose-Einstein condensates. We demonstrate that they are several orders of magnitude more dilute than liquid helium by directly measuring their size and density via in situ imaging. We show that the droplets are stablized against collapse by quantum fluctuations and that they require a minimum atom number to be stable. Below that number, quantum pressure drives a liquid-to-gas transition that we map out as a function of interaction strength. These ultradilute isotropic liquids remain weakly interacting and constitute an ideal platform to benchmark quantum many-body theories.

We investigate the size of discrete time crystals s (ratio of response period to driving period) that can be created for a Bose-Einstein condensate (BEC) bouncing resonantly on an oscillating mirror. We find that time crystals can be created with sizes in the range s ≈ 20-100 and that such big time crystals are easier to realize experimentally than a period-doubling (s=2) time crystal because they require either a larger drop height or a smaller number of bounces on the mirror. We also investigate the effects of having a realistic soft Gaussian potential mirror for the bouncing BEC, such as that produced by a repulsive light-sheet, which is found to make the experiment easier to implement than a hard-wall potential mirror. Finally, we discuss the choice of atomic system for creating time crystals based on a bouncing BEC and present an experimental protocol for realizing big time crystals. Such big time crystals provide a flexible platform for investigating a broad range of non-trivial condensed matter phenomena in the time domain.

Despite almost a century's worth of study, it is still unclear how general relativity (GR) and quantum theory (QT) should be unified into a consistent theory. The conventional approach is to retain the foundational principles of QT, such as the superposition principle, and modify GR. This is referred to as 'quantizing gravity', resulting in a theory of 'quantum gravity'. The opposite approach is 'gravitizing QT' where we attempt to keep the principles of GR, such as the equivalence principle, and consider how this leads to modifications of QT. What we are most lacking in understanding which route to take, if either, is experimental guidance. Here we consider using a Bose-Einstein condensate (BEC) to search for clues. In particular, we study how a single BEC in a superposition of two locations could test a gravitizing QT proposal where wavefunction collapse emerges from a unified theory as an objective process, resolving the measurement problem of QT. Such a modification to QT due to general relativistic principles is testable near the Planck mass scale, which is much closer to experiments than the Planck length scale where quantum, general relativistic effects are traditionally anticipated in quantum gravity theories. Furthermore, experimental tests of this proposal should be simpler to perform than recently suggested experiments that would test the quantizing gravity approach in the Newtonian gravity limit by searching for entanglement between two massive systems that are both in a superposition of two locations.

Understanding the characteristics of cancer cells is essential for the development of improved diagnosis and therapeutics. From a gene regulation perspective, the super‐enhancer concept has been introduced to systematically understand the molecular mechanisms underlying the identities of various cell types and has been extended to the analysis of cancer cells and cancer genome alterations. In addition, several characteristic features of super‐enhancers have led to the recognition of the link between gene regulation and biomolecular condensates, which is often mediated by liquid‐liquid phase separation. Several lines of evidence have suggested molecular and biophysical principles and their alterations in cancer cells, which are particularly associated with gene regulation and cell signaling (“ transcriptional” and “signaling” condensates). These findings collectively suggest that the modification of biomolecular condensates represents an important mechanism by which cancer cells acquire various cancer hallmark traits and establish functional innovation for cancer initiation and progression. The condensate model also provides the molecular basis of the vulnerability of cancer cells to transcriptional perturbation and further suggests the possibility of therapeutic targeting of condensates. This review summarizes recent findings regarding the relationships between super‐enhancers and biomolecular condensate models, multiple scenarios of condensate alterations in cancers, and the potential of the condensate model for therapeutic development. In this review, we summarize recent findings regarding the relationships between super‐enhancers and the biomolecular condensates, multiple scenarios of condensate alterations in cancer, and the potentials of the condensate model for therapeutic development. Modification of biomolecular condensates may be important mechanisms by which cancer cells acquire various cancer hallmark traits and establish functional innovation for cancer initiation and progression.

We report the observation of coherent circulation in a macroscopic Bose–Einstein condensate of polaritons in a ring geometry. Because they are spinor condensates, half-quanta are allowed in where there is a phase rotation of π in connection with a polarization vector rotation of π around a closed path. This half-quantum behavior is clearly seen in the experimental observations of the polarization rotation around the ring. In our ring geometry, the half-quantum state that we see is one in which the handedness of the spin flips from one side of the ring to the other side in addition to the rotation of the linear polarization component; such a state is allowed in a ring geometry but will not occur in a simply connected geometry. This state is lower in energy than a half-quantum state with no change of the spin direction and corresponds to a superposition of two different elementary half-quantum states. The direction of circulation of the flow around the ring fluctuates randomly between clockwise and counterclockwise from one shot to the next; this fluctuation corresponds to spontaneous breaking of time-reversal symmetry in the system. This type of macroscopic polariton ring condensate allows for the possibility of direct control of the circulation to excite higher quantized states and the creation of Josephson junction tunneling barriers. Significance Polaritons are propagating states in certain solid-state systems that couple directly to light signals. This work gives a clear observation of quantized circulation of a polariton condensate in a ring; spontaneous quantized circulation is one of the key tests of true superfluidity. The quantized circulation seen here is a new type that is only possible in a spinor condensate in a ring geometry. Because polariton condensates can be made relatively easily in solid-state systems that can operate up to room temperature, the door is open to all kinds of superfluid effects of light in optical communications.