Journal Article

Endometrial cancer

Crosbie, Emma J, Mukhopadhyay, Asima, Singh, Naveena, Kitson, Sarah J, Powell, Melanie E, McAlpine, Jessica N

2022

نظرة عامة

Endometrial cancer is the most common gynaecological cancer in high income countries and its incidence is rising globally. Although an ageing population and fewer benign hysterectomies have contributed to this trend, the growing prevalence of obesity is the major underlying cause. Obesity poses challenges for diagnosis and treatment and more research is needed to offer primary prevention to high-risk women and to optimise endometrial cancer survivorship. Early presentation with postmenopausal bleeding ensures most endometrial cancers are cured by hysterectomy but those with advanced disease have a poor prognosis. Minimally invasive surgical staging and sentinel-lymph-node biopsy provides a low morbidity alternative to historical surgical management without compromising oncological outcomes. Adjuvant radiotherapy reduces loco-regional recurrence in intermediate-risk and high-risk cases. Advances in our understanding of the molecular biology of endometrial cancer have paved the way for targeted chemotherapeutic strategies, and clinical trials will establish their benefit in adjuvant, advanced, and recurrent disease settings in the coming years.

• الناشر: Elsevier Ltd,Elsevier Limited
• موضوع: Abdomen / Age / Aging / Biopsy / Cancer / Chemotherapy / Clinical trials / Diabetes / Endometrial cancer / Endometrium / Gynecological cancer / Hysterectomy / Insulin-like growth factors / Low income groups / Medical screening / Menstruation / Molecular biology / Morbidity / Mortality / Obesity / Pathology / Polycystic ovary syndrome / Post-menopause / Radiation therapy / Risk / Risk factors / Survival / Ultrasonic imaging / Womens health