Journal Article

CXCL10 IP-10: A missing link between inflammation and anti-angiogenesis in preeclampsia?

Kusanovic, Juan Pedro, Espinoza, Jimmy, Yoon, Bo Hyun, Hassan, Sonia S., Kim, Chong Jai, Romero, Roberto, Mittal, Pooja, Chaiworapongsa, Tinnakorn, Than, Nandor Gabor, Erez, Offer, Mazaki-Tovi, Shali, Gotsch, Francesca, Edwin, Samuel, Friel, Lara

2007

نظرة عامة

Objective. Interferon (IFN)-γ inducible protein, CXCL10 IP-10, is a member of the CXC chemokine family with pro-inflammatory and anti-angiogenic properties. This chemokine has been proposed to be a key link between inflammation and angiogenesis. The aim of this study was to determine whether preeclampsia and delivery of a small for gestational age (SGA) neonate are associated with changes in maternal serum concentration of CXCL10 IP-10. Study design. This cross-sectional study included patients in the following groups: (1) non-pregnant women (N = 49); (2) women with normal pregnancies (N = 89); (3) patients with preeclampsia (N = 100); and (4) patients who delivered an SGA neonate (N = 78). SGA was defined as birth weight below the 10th percentile. Maternal serum concentrations of CXCL10 IP-10 were measured by sensitive immunoassay. Non-parametric statistics were used for analysis. Results. (1) Patients with normal pregnancies had a significantly higher median serum concentration of CXCL10 IP-10 than non-pregnant women (median 116.1 pg mL, range 40.7-1314.3 vs. median 90.3 pg mL, range 49.2-214.7, respectively; p = 0.002); (2) no significant correlation was found between maternal serum concentration of CXCL10 IP-10 and gestational age (between 19 and 38 weeks); (3) there were no differences in median serum CXCL10 IP-10 concentrations between patients who delivered an SGA neonate and those with normal pregnancies (median 122.4 pg mL, range 37.3-693.5 vs. median 116.1 pg mL, range 40.7-1314.3, respectively; p > 0.05); (4) patients with preeclampsia had a higher median serum concentration of CXCL10 IP-10 than normal pregnant women (median 156.4 pg mL, range 47.4-645.9 vs. median 116.1 pg mL, range 40.7-1314.3, respectively; p < 0.05); (5) patients with preeclampsia had a higher median concentration of CXCL10 IP-10 than those who delivered an SGA neonate (median 156.4 pg mL, range 47.4-645.9 vs. median 122.4 pg mL, range 37.3-693.5, respectively; p < 0.05). Conclusions. Patients with preeclampsia have significantly higher serum concentrations of CXCL10 IP-10 than both normal pregnant women and mothers who have SGA neonates. These results are likely to reflect an anti-angiogenic state as well as an enhanced systemic inflammatory response in patients with preeclampsia. Alternatively, since preeclampsia and SGA share several mechanisms of disease, it is possible that a higher concentration of this chemokine may contribute to the clinical presentation of preeclampsia in patients with a similar intrauterine insult.

• الناشر: Informa UK Ltd,Taylor & Francis,Taylor & Francis Ltd
• موضوع: Adolescent / Adult / angiogenesis / chemokine / Chemokine CXCL10 - blood / chemotactic cytokine / Cross-Sectional Studies / CXCL10 / Female / Humans / Infant, Newborn / Infant, Small for Gestational Age / Inflammation - blood / IP-10 / Neovascularization, Physiologic / Pre-Eclampsia - blood / Pregnancy / Retrospective Studies / SGA / small for gestational age