تفاصيل الأصول
هل ترغب في حجز الكتاب؟
Contrast enhancement predicting survival in integrated molecular subtypes of diffuse glioma: an observational cohort study
لقد وضعنا الحجز لك!
بالمناسبة ، لماذا لا تستكشف الفعاليات التي يمكنك حضورها عند زيارتك للمكتبة لإستلام كتبك
هل أنت متأكد أنك تريد إزالة الكتاب من الرف؟
Contrast enhancement predicting survival in integrated molecular subtypes of diffuse glioma: an observational cohort study
هل تريد طلب الكتاب؟
Contrast enhancement predicting survival in integrated molecular subtypes of diffuse glioma: an observational cohort study
يرجى العلم أن الكتاب الذي طلبته لا يمكن استعارته. إذا كنت ترغب في إستعارة هذا الكتاب ، يمكنك حجز نسخة أخرى
Journal Article
Contrast enhancement predicting survival in integrated molecular subtypes of diffuse glioma: an observational cohort study
2018
نظرة عامة
Purpose: To assess the predictive value of MRI gadolinium enhancement as a prognostic factor in the 2016 CNS WHO integrated glioma groups. Methods: 450 glioma patients were retrospectively assessed using gadolinium enhancement, survival, and relevant prognostic molecular data [isocitrate dehydrogenase (IDH); alpha-thalassemia/mental retardation syndrome X-linked (ATRX); chromosome 1p/19q loss of heterozygosity; and O6-methylguanine DNA methyltransferase (MGMT)]. Kaplan-Meier method was used to assess univariate survival data. Multivariate Cox proportional hazards model was performed on significant results from the univariate analysis. Results: There were significant differences in survival between patient age (p < 0.0001), WHO glioma grades (p < 0.0001), and integrated molecular profiles (p < 0.0001). Patients with IDH1/2 mutation, loss of ATRX expression, and methylated MGMT promoter showed significantly better survival than those with the IDH wild type (p < 0.0001), retained ATRX expression (p < 0.0001), and unmethylated MGMT promoter (p = 0.019). Survival was significantly better in patients without gadolinium enhancement (p = 0.009) who were in the IDH wild type glioma and glioma with retained ATRX expression groups (p = 0.018 and 0.030, respectively). Conclusion: In univariate analysis, the presence of gadolinium enhancement on preoperative MRI scans is an unfavorable factor for survival. Regarding the molecular subgroups, gadolinium enhancement is an unfavorable prognostic factor in gliomas with IDH wild type and those with ATRX retention. However, in multivariate analysis only patient age, IDH1/2 mutation status, MGMT promoter methylation status, and WHO grade IV are relevant for predicting survival.
الناشر
Springer
موضوع
