Journal Article

Population genomics of ancient and modern Trichuris trichiura

Sandoval, Gustavo Adolfo Fontecha, Kapel, Christian Moliin Outzen, Doyle, Stephen R., Betson, Martha, Matamoros, Gabriela, Sanchez, Ana, Søe, Martin Jensen, Zhu, Xing-Quan, Cutillas, Cristina, Tchuenté, Louis-Albert Tchuem, Cooper, Philip J., Berriman, Matthew, Peng, Lifei, Mekonnen, Zeleke, Ame, Shaali M., Namwanje, Harriet, Fredensborg, Brian Lund, Nejsum, Peter, Levecke, Bruno

2022

نظرة عامة

The neglected tropical disease trichuriasis is caused by the whipworm Trichuris trichiura , a soil-transmitted helminth that has infected humans for millennia. Today, T. trichiura infects as many as 500 million people, predominantly in communities with poor sanitary infrastructure enabling sustained faecal-oral transmission. Using whole-genome sequencing of geographically distributed worms collected from human and other primate hosts, together with ancient samples preserved in archaeologically-defined latrines and deposits dated up to one thousand years old, we present the first population genomics study of T. trichiura . We describe the continent-scale genetic structure between whipworms infecting humans and baboons relative to those infecting other primates. Admixture and population demographic analyses support a stepwise distribution of genetic variation that is highest in Uganda, consistent with an African origin and subsequent translocation with human migration. Finally, genome-wide analyses between human samples and between human and non-human primate samples reveal local regions of genetic differentiation between geographically distinct populations. These data provide insight into zoonotic reservoirs of human-infective T. trichiura and will support future efforts toward the implementation of genomic epidemiology of this globally important helminth. The whipworm Trichuris trichiura is a soil-transmitted helminth that causes the neglected tropical disease trichuriasis in humans. Here, the authors produce whole genome sequences of modern and ancient samples from humans and non-human primates to characterise the genomic diversity and evolution of this pathogen.

• الناشر: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• موضوع: 45/22 / 45/23 / 631/326/417/2548 / 631/326/417/2551 / 692/700/478/174 / Animals / Archaeology / Epidemiology / Gene sequencing / Genetic diversity / Genetic structure / Genome-Wide Association Study / Genomes / Genomics / Geographical distribution / Humanities and Social Sciences / Humans / Metagenomics / Migration / Monkeys & apes / multidisciplinary / Phylogeny / Population studies / Primates / Primates - genetics / Science / Science (multidisciplinary) / Soils / Translocation / Trichuriasis - epidemiology / Trichuris - genetics / Trichuris trichiura / Tropical diseases / Whole genome sequencing