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![Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases](https://www.mbrl.ae/o/mbrl-theme/images/site-assets/generic/no-book-image.png)
Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
بواسطة
Xiao, Bowen
, Tan, Jianglin
, Liu, Tengfei
, Xiang, Fei
, Zhang, Xiaorong
, Mao, Zhengwei
, Chen, Xiaoyuan
, Deng, Jun
, Chen, Zhuo
, Wu, Chengzhou
, Luo, Gaoxing
في
Acute Kidney Injury - blood
/ Acute Kidney Injury - pathology
/ Acute Kidney Injury - therapy
/ Alanine Transaminase - blood
/ Animals
/ Antioxidants - chemistry
/ Aspartate Aminotransferases - blood
/ Biocompatibility
/ Catalase
/ Cattle
/ Clinical outcomes
/ Copper
/ Copper - chemistry
/ Copper - pharmacokinetics
/ Diseases
/ Enzymes
/ Female
/ Free Radical Scavengers - chemistry
/ Glutathione
/ Glutathione peroxidase
/ Health services
/ HEK293 Cells
/ Humans
/ Inflammation - pathology
/ Inflammatory diseases
/ Injuries
/ Kidneys
/ Liver
/ Medical treatment
/ Mice
/ Mice, Inbred BALB C
/ Mice, Inbred C57BL
/ Mimicry
/ Nanomaterials
/ Nanoparticles
/ Nanoparticles - chemistry
/ Nanoparticles - ultrastructure
/ Nanotechnology
/ Oxidative stress
/ Oxygen
/ Particle Size
/ Peroxidase
/ Principal Component Analysis
/ Rats, Sprague-Dawley
/ Reactive oxygen species
/ Reactive Oxygen Species - chemistry
/ Scavenging
/ Superoxide dismutase
/ Tissue Distribution
/ Wound Healing
2020
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![](https://www.mbrl.ae/o/mbrl-theme/images/site-assets/generic/no-book-image.png)
Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
بواسطة
Xiao, Bowen
, Tan, Jianglin
, Liu, Tengfei
, Xiang, Fei
, Zhang, Xiaorong
, Mao, Zhengwei
, Chen, Xiaoyuan
, Deng, Jun
, Chen, Zhuo
, Wu, Chengzhou
, Luo, Gaoxing
في
Acute Kidney Injury - blood
/ Acute Kidney Injury - pathology
/ Acute Kidney Injury - therapy
/ Alanine Transaminase - blood
/ Animals
/ Antioxidants - chemistry
/ Aspartate Aminotransferases - blood
/ Biocompatibility
/ Catalase
/ Cattle
/ Clinical outcomes
/ Copper
/ Copper - chemistry
/ Copper - pharmacokinetics
/ Diseases
/ Enzymes
/ Female
/ Free Radical Scavengers - chemistry
/ Glutathione
/ Glutathione peroxidase
/ Health services
/ HEK293 Cells
/ Humans
/ Inflammation - pathology
/ Inflammatory diseases
/ Injuries
/ Kidneys
/ Liver
/ Medical treatment
/ Mice
/ Mice, Inbred BALB C
/ Mice, Inbred C57BL
/ Mimicry
/ Nanomaterials
/ Nanoparticles
/ Nanoparticles - chemistry
/ Nanoparticles - ultrastructure
/ Nanotechnology
/ Oxidative stress
/ Oxygen
/ Particle Size
/ Peroxidase
/ Principal Component Analysis
/ Rats, Sprague-Dawley
/ Reactive oxygen species
/ Reactive Oxygen Species - chemistry
/ Scavenging
/ Superoxide dismutase
/ Tissue Distribution
/ Wound Healing
2020
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![Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases](https://www.mbrl.ae/o/mbrl-theme/images/site-assets/generic/no-book-image.png)
Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
بواسطة
Xiao, Bowen
, Tan, Jianglin
, Liu, Tengfei
, Xiang, Fei
, Zhang, Xiaorong
, Mao, Zhengwei
, Chen, Xiaoyuan
, Deng, Jun
, Chen, Zhuo
, Wu, Chengzhou
, Luo, Gaoxing
في
Acute Kidney Injury - blood
/ Acute Kidney Injury - pathology
/ Acute Kidney Injury - therapy
/ Alanine Transaminase - blood
/ Animals
/ Antioxidants - chemistry
/ Aspartate Aminotransferases - blood
/ Biocompatibility
/ Catalase
/ Cattle
/ Clinical outcomes
/ Copper
/ Copper - chemistry
/ Copper - pharmacokinetics
/ Diseases
/ Enzymes
/ Female
/ Free Radical Scavengers - chemistry
/ Glutathione
/ Glutathione peroxidase
/ Health services
/ HEK293 Cells
/ Humans
/ Inflammation - pathology
/ Inflammatory diseases
/ Injuries
/ Kidneys
/ Liver
/ Medical treatment
/ Mice
/ Mice, Inbred BALB C
/ Mice, Inbred C57BL
/ Mimicry
/ Nanomaterials
/ Nanoparticles
/ Nanoparticles - chemistry
/ Nanoparticles - ultrastructure
/ Nanotechnology
/ Oxidative stress
/ Oxygen
/ Particle Size
/ Peroxidase
/ Principal Component Analysis
/ Rats, Sprague-Dawley
/ Reactive oxygen species
/ Reactive Oxygen Species - chemistry
/ Scavenging
/ Superoxide dismutase
/ Tissue Distribution
/ Wound Healing
2020
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Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
![Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases](https://syndetics.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=MBRL&type=mbrl)
Journal Article
Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
2020
اطلب الآن
واختر طريقة الاستلام
نظرة عامة
Oxidative stress is associated with many acute and chronic inflammatory diseases, yet limited treatment is currently available clinically. The development of enzyme-mimicking nanomaterials (nanozymes) with good reactive oxygen species (ROS) scavenging ability and biocompatibility is a promising way for the treatment of ROS-related inflammation. Herein we report a simple and efficient one-step development of ultrasmall Cu
O nanoparticles (Cu
O USNPs) with multiple enzyme-mimicking and broad-spectrum ROS scavenging ability for the treatment of ROS-related diseases. Cu
O USNPs simultaneously possessing catalase-, superoxide dismutase-, and glutathione peroxidase-mimicking enzyme properties exhibit cytoprotective effects against ROS-mediated damage at extremely low dosage and significantly improve treatment outcomes in acute kidney injury, acute liver injury and wound healing. Meanwhile, the ultrasmall size of Cu
O USNPs enables rapid renal clearance of the nanomaterial, guaranteeing the biocompatibility. The protective effect and good biocompatibility of Cu
O USNPs will facilitate clinical treatment of ROS-related diseases and enable the development of next-generation nanozymes.
الناشر
Nature Publishing Group,Nature Publishing Group UK,Nature Portfolio
موضوع
/ Acute Kidney Injury - pathology
/ Acute Kidney Injury - therapy
/ Alanine Transaminase - blood
/ Animals
/ Aspartate Aminotransferases - blood
/ Catalase
/ Cattle
/ Copper
/ Diseases
/ Enzymes
/ Female
/ Free Radical Scavengers - chemistry
/ Humans
/ Injuries
/ Kidneys
/ Liver
/ Mice
/ Mimicry
/ Nanoparticles - ultrastructure
/ Oxygen
/ Principal Component Analysis
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