Journal Article

Retinal and choroidal efficacy of switching treatment to faricimab in recalcitrant neovascular age related macular degeneration

Lorger, Anna, Klaas, Julian Elias, Schworm, Benedikt, Kreutzer, Thomas Christian, Hafner, Michael, Priglinger, Siegfried Georg, Eckardt, Franziska, Siedlecki, Jakob

2024

نظرة عامة

Aim of this study was to evaluate the efficacy of switching treatment to faricimab in neovascular age-related macular degeneration (nAMD) from other anti-VEGF agents. Fifty-eight eyes of fifty-one patients with nAMD and a full upload series of four faricimab injections were included. Demographic data, multimodal imaging and treatment parameters were recorded. The primary outcome measures were changes in central subfield thickness (CST) and subfoveal choroidal thickness (SFCT). A subgroup analysis was performed for eyes with prior ranibizumab (R) or aflibercept (A) treatment. Mean injection intervals before and after switching were comparable (33.8 ± 11.2 vs. 29.3 ± 2.6 days; p  = 0.08). Mean CST of 361.4 ± 108.1 µm prior to switching decreased significantly to 318.3 ± 97.7 µm ( p  < 0.01) after the third faricimab injection, regardless of prior anti-VEGF treatment ( p  < 0.01). Although SFCT slightly improved for the whole cohort from 165.8 ± 76.8 µm to 161.0 ± 82,8 µm ( p  = 0.029), subgroup analysis did not confirm this positive effect (subgroup R: p  = 0.604; subgroup A: p  = 0.306). In patients with a suboptimal response to aflibercept or ranibizumab in nAMD, farcimab can improve CST and slightly improve or maintain SFCT. Further prospective randomized trials are warranted.

• الناشر: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• موضوع: 692/699/3161/1626 / 692/699/3161/3175 / Age / Aged / Aged, 80 and over / Angiogenesis Inhibitors - administration & dosage / Angiogenesis Inhibitors - therapeutic use / Choroid - diagnostic imaging / Choroid - drug effects / Choroid - pathology / Clinical trials / Drug Substitution / Female / Humanities and Social Sciences / Humans / Injection / Intravitreal Injections / Macular degeneration / Macular Degeneration - drug therapy / Macular Degeneration - pathology / Male / Monoclonal antibodies / multidisciplinary / Ranibizumab - administration & dosage / Ranibizumab - therapeutic use / Receptors, Vascular Endothelial Growth Factor - administration & dosage / Receptors, Vascular Endothelial Growth Factor - therapeutic use / Recombinant Fusion Proteins - administration & dosage / Recombinant Fusion Proteins - therapeutic use / Retina - diagnostic imaging / Retina - drug effects / Retina - pathology / Science / Science (multidisciplinary) / Tomography, Optical Coherence / Treatment Outcome / Vascular endothelial growth factor / Vascular Endothelial Growth Factor A - antagonists & inhibitors / Visual Acuity - drug effects