Journal Article

Fine-Tuned Expression of Programmed Death 1 Ligands in Mature Dendritic Cells Stimulated by CD40 Ligand is Critical for the Induction of an Efficient Tumor Specific Immune Response

Tao Gu Yibei Zhu Cheng Chen Min Li Yongjing Chen Gehua Yu Yan Ge Shiyong Zhou Huan Zhou Yong Huang Yuhua Qiu Xueguang Zhang

2008

نظرة عامة

During maturation, murine myeloid dendritic cells （DCs） upregulated the expressions of CDllc, CD25, CD40, CD80, CD86, MHC Ⅱ and programmed death 1 ligands 1 and 2 （PD-L1 and PD-L2）. Differential expression patterns of PD-L1 and PD-L2 were found when DCs were triggered by CD40 ligand and TNF-α. PD-L1 expression was repressed and PD-L2 expression remained unchanged in mature CD40-ligated DCs, whereas TNF-α stimulated DCs kept high expression of PD-L1 and significantly enhanced PD-L2 expression on DCs. Proliferations of T lymphocytes stimulated by immature DCs were enhanced by blockade of the PD-1 and PD-1 ligand interaction. But inhibitive effects were found in T lymphocytes stimulated by CD40-ligated DCs. With the fine-tuned expressions of PD-L1 and PD-L2, CD40-1igated DCs could sustain a longer activation period and elicit a more efficient T lymphocyte activation. Cellular ＆ Molecular Immunology.

• الناشر: Nature Publishing Group UK,Nature Publishing Group,Medical Biotechnology Institute and Clinical Immunology Laboratory for Jiangsu Province, Soochow University, Suzhou, Jiangsu 215007, China,Tao Gu and Yi-Bei Zhu contributed equally to this work%Medical Biotechnology Institute and Clinical Immunology Laboratory for Jiangsu Province, Soochow University, Suzhou, Jiangsu 215007, China
• موضوع: Animals / Antibodies / Apoptosis / B7-1 Antigen - immunology / B7-1 Antigen - metabolism / B7-H1 Antigen / Biomedical and Life Sciences / Biomedicine / CD11c antigen / CD25 antigen / CD40 antigen / CD40 Ligand - immunology / CD40 Ligand - metabolism / CD80 antigen / CD86 antigen / Cell activation / Cell Line, Tumor / Cell Proliferation / Dendritic cells / Dendritic Cells - immunology / Dendritic Cells - metabolism / Down-Regulation / Female / Immunology / Ligands / Lymphocyte Activation / Lymphocytes T / Major histocompatibility complex / Medical Microbiology / Membrane Glycoproteins - immunology / Membrane Glycoproteins - metabolism / Mice / Mice, Inbred BALB C / Mice, Inbred C57BL / Microbiology / Neoplasms - immunology / PD-1 protein / PD-L1 protein / Peptides - immunology / Peptides - metabolism / Programmed Cell Death 1 Ligand 2 Protein / T-Lymphocytes - immunology / T-Lymphocytes - metabolism / Tumor Necrosis Factor-alpha - immunology / Tumor Necrosis Factor-alpha - metabolism / Tumor necrosis factor-α / Tumors / Vaccine / 免疫系统 / 配合基