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251 result(s) for "Gilbert, Sara,"
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Middle Eastern food
\"An elementary introduction to the relationship between cooking and Middle Eastern food, the effect of local agriculture on the diets of different regions, common tools such as pestles, and recipe instructions\"-- Provided by publisher.
Oxidative Stress Contributes to Soluble Fms-Like Tyrosine Kinase-1 Induced Vascular Dysfunction in Pregnant Rats
Background Recent evidence indicates that both increased oxidative stress and an altered balance between pro- and anti-angiogenic factors such as vascular-endothelial growth factor (VEGF) and the soluble VEGF receptor (sFlt-1) contribute to endothelial dysfunction in preeclampsia. We hypothesized that chronic infusion of sFlt-1 to mimic the increase observed in preeclamptic patients would reduce plasma VEGF concentrations, increase blood pressure (BP) and vascular superoxide levels, and cause endothelial dysfunction in the pregnant rat. Methods Recombinant sFlt-1 was infused (500 ng/h) during days 13–18 of pregnancy. BP, fetal and placental weight, oxidative stress and vessel vasorelaxation were determined on day 18 of pregnancy. Results Plasma sFlt-1 concentrations (299 ± 33 vs. 100 ± 16 pg/ml; P < 0.01) and BP (117 ± 6 vs. 98 ± 4 mm Hg; P < 0.01) were increased, while plasma-free VEGF concentrations (570 ± 77 vs. 780 ± 48 pg/ml; P < 0.01) were decreased when compared to vehicle infused dams. sFlt-1 rats had smaller fetuses (1.3 ± 0.03 vs. 1.5 ± 0.04 g, P < 0.01) and placentas (0.41 ± 0.01 vs. 0.47 ± 0.02 g; P < 0.05). Placental (180 ± 66 vs. 24 ± 2.3 RLU/min/mg; P < 0.05) and vascular (34 ± 8 vs. 12 ± 5 RLU/min/mg; P < 0.05) superoxide production was increased in the sFlt-1 compared to vehicle infused rats. Vasorelaxation to acetylecholine (ACh) and sodium nitroprusside (SNP) were both decreased (P < 0.05) in the sFlt-1 infusion group compared to the vehicle and this decrease was attenuated (P < 0.05) by the superoxide scavenger Tiron. Conclusion These data indicate elevated maternal sFlt-1 and decreased VEGF concentrations results in increased oxidative stress that contributes to vascular dysfunction during pregnancy.
The Role of Digital Spaces in Caring for Children with Feeding Tubes: Home, Family, and Community Reconsidered
This dissertation draws from feminist geographic research to critically examine the landscapes of care traversed by family caregivers of children with feeding tubes and complex medical and long-term care needs. Drawing from theories and methodologies from feminist disability and digital geographies, in combination with feminist science technology studies (STS), I explore the impact of neoliberal policy changes on daily caregiving tasks and how families, in response to these policy changes, (re)create digital spaces and relationships to satisfy their unmet needs. This research examines the growing and shifting roles of digital spaces in the everyday lives of marginalized and/or vulnerable communities to determine how digital spaces are (re)created by family caregivers and reflect how community relationships and digital activities impact family caregivers’ ability to give care within precarious situations. A comprehensive examination of the Feeding Tube Awareness Foundation’s (FTAF) online resources accessed by family caregivers serves as a case study for this project. I argue that digital spaces, like FTAF, are essential places in family caregivers’ everyday geographies and are constituted by co-constructed relationships shaped and maintained by the digitally mediated activities of community actors (human and nonhuman) across multiple spaces and times. By incorporating Science and Technology Studies' theoretical and methodological insights, rare in the digital geography literature, this project attends to the diversity, structure, and internal dynamics within and among digital relationships in maintaining and transforming these digital communities, particularly deep web places like FAFT’s Facebook group and the fluidity of user subjectivity across multiple digital places.
Aspirations and Anxieties: The Neoliberal Geopolitics of the NIC
This thesis is a critical reading of Global Trends 2025 that focuses on discourses of globalization, technology, and images of the Other.