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2 result(s) for "韩希望 杨德庆 何文宪 王国荣"
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肝素结合表皮生长因子在皮肤鳞癌中的免疫组化研究
目的 探讨HB-EGF在皮肤鳞状细胞癌中的作用机制。方法 用免疫组化的方法检测正常组织,癌旁组织和鳞状细胞癌皮损中HB-EGF蛋白表达。结果 在正常皮肤组织中,HB-EGF、表达于基底层(100.0%),基底上层仅有少量表达(12.5%);在癌旁组织中,HB-EGF不仅位于基底层(100.0%),且在基底上层中也有表达(91.7%);在鳞状细胞癌皮损中,几乎无HB-EGF、的表达(8.3%)。结论 HB-EGF在鳞状细胞癌发病的早期阶段起关键作用,基底层中的:HB-EGF对保持正常表皮形态有重要的作用。
Immunohistochemical study of heparin binding epidermal growth factor-like growth factor in skin squamous cell carcinoma / 肝素结合表皮生长因子在皮肤鳞癌中的免疫组化研究
目的探讨HB-EGF在皮肤鳞状细胞癌中的作用机制.方法用免疫组化的方法检测正常组织,癌旁组织和鳞状细胞癌皮损中HB-EGF蛋白表达.结果在正常皮肤组织中,HB-EGF表达于基底层(100.0%),基底上层仅有少量表达(12.5%);在癌旁组织中,HB-EGF不仅位于基底层(100.0%),且在基底上层中也有表达(91.7%);在鳞状细胞癌皮损中,几乎无HB-EGF的表达(8.3%).结论 HB-EGF在鳞状细胞癌发病的早期阶段起关键作用,基底层中的HB-EGF对保持正常表皮形态有重要的作用.