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Pile foundation is an effective technique to support buildings in the presence of soft soil and seismic areas. More recently, the rigid inclusions system has also been utilized for founding buildings. Both systems increase the bearing capacity of the soil and allow reducing the total and differential settlements in the structure. However, the study of these systems in a complete and accurate way implies the consideration of the soil–structure interaction (SSI). In order to investigate the impact of different pile toe conditions (including the placement on hard soil, an anchorage and floating piles) in the response of mid-rise buildings, numerical models with a 5-storey frame building founded on the inclusions system (soil–inclusion–platform–structure) are analyzed and compared with the pile system (soil–pile–structure). Fully coupled finite difference numerical models were developed using Flac 3D. The influence of the dynamic characteristics of the structure was considered analyzing buildings with different heights (3 storeys to 7 storeys). The linear elastic perfectly plastic model with a Mohr–Coulomb failure criterion is used to represent the behavior of the soil. Values of the maximum lateral displacements, of the inter-storey drifts and of the shear forces distribution in the buildings, as well as the rocking of the foundation, are presented. Concerning the foundations, efforts and displacements are compared for the different systems. The results show that the type of support condition influences the seismic response of the building and the efforts and displacements in the rigid elements, depending on the foundation system. The efforts at the toe level in the rigid elements are highly influenced by the support conditions, but there is only a slight influence from the head connection.

The Imaging Magnetograph eXperiment (IMaX) is a spectropolarimeter built by four institutions in Spain that flew on board the Sunrise balloon-borne solar observatory in June 2009 for almost six days over the Arctic Circle. As a polarimeter, IMaX uses fast polarization modulation (based on the use of two liquid crystal retarders), real-time image accumulation, and dual-beam polarimetry to reach polarization sensitivities of 0.1%. As a spectrograph, the instrument uses a LiNbO 3 etalon in double pass and a narrow band pre-filter to achieve a spectral resolution of 85 mÅ. IMaX uses the high-Zeeman-sensitive line of Fe i at 5250.2 Å and observes all four Stokes parameters at various points inside the spectral line. This allows vector magnetograms, Dopplergrams, and intensity frames to be produced that, after reconstruction, reach spatial resolutions in the 0.15 – 0.18 arcsec range over a 50×50 arcsec field of view. Time cadences vary between 10 and 33 s, although the shortest one only includes longitudinal polarimetry. The spectral line is sampled in various ways depending on the applied observing mode, from just two points inside the line to 11 of them. All observing modes include one extra wavelength point in the nearby continuum. Gauss equivalent sensitivities are 4 G for longitudinal fields and 80 G for transverse fields per wavelength sample. The line-of-sight velocities are estimated with statistical errors of the order of 5 – 40 m s −1 . The design, calibration, and integration phases of the instrument, together with the implemented data reduction scheme, are described in some detail.

Our knowledge about the solar chromosphere and transition region (TR) has increased in the last decade thanks to the huge scientific return of space-borne observatories like SDO, IRIS, and Hinode, and suborbital rocket experiments like CLASP1, CLASP2, and Hi-C. However, the magnetic nature of those solar regions remain barely explored. The chromosphere and TR of the Sun harbor weak fields and are in a low ionization stage both having critical effects on their thermodynamic behavior. Relatively cold gas structures, such as spicules and prominences, are located in these two regions and display a dynamic evolution in high-resolution observations that static and instantaneous 3D-magnetohydrodynamic (MHD) models are not able to reproduce. The role of the chromosphere and TR as the necessary path to a (largely unexplained) very hot corona calls for the generation of observationally based, time-dependent models of these two layers that include essential, up to now disregarded, ingredients in the modeling such as the vector magnetic field. We believe that the community is convinced that the origin of both the heat and kinetic energy observed in the upper layers of the solar atmosphere is of magnetic origin, but reliable magnetic field measurements are missing. The access to sensitive polarimetric measurements in the ultraviolet wavelengths has been elusive until recently due to limitations in the available technology. We propose a low-risk and high-Technology Readiness Level (TRL) mission to explore the magnetism and dynamics of the solar chromosphere and TR. The mission baseline is a low-Earth, Sun-synchronous orbit at an altitude between 600 and 800 km. The proposed scientific payload consists of a 30 cm aperture telescope with a spectropolarimeter covering the hydrogen Ly-alpha and the Mg II h&k ultraviolet lines. The instrument shall record high-cadence, full spectropolarimetric observations of the solar upper atmosphere. Besides the answers to a fundamental solar problem the mission has a broader scientific return. For example, the time-dependent modeling of the chromospheres of stars harboring exoplanets is fundamental for estimating the planetary radiation environment. The mission is based on technologies that are mature enough for space and will provide scientific measurements that are not available by other means.

Background and Objectives: Colon cancer (CC) is prevalent globally, constituting 11.9% of cases in Mexico. Lymph node metastases are established prognostic indicators, with extracapsular lymph node extension (ENE) playing a crucial role in modifying prognosis. While ENE is associated with adverse factors, certain aspects, like matted nodes (lymph node conglomerates), are underexplored. Matted nodes, clusters of lymph nodes infiltrated by cancer cells, are recognized as an independent prognostic factor in other cancers. This study investigates the prognostic implications of matted nodes in CC. Materials and Methods: From a retrospective analysis of 502 CC consecutive cases treated with colectomy (2005–2018), we identified 255 (50.8%) cases with lymph node metastasis (our study group), which were categorized into two groups: (1) lymph node metastasis alone (n = 208), and (2) lymph node metastasis with matted nodes (n = 47). A comparative survival analysis was performed. Results: Of the 255 patients, 38% had lymph node metastasis. Patients with matted nodes (18.4%) showed an association with higher pN stage and lymphovascular invasion. The 5-year survival rate for patients with matted nodes was 47.7%, compared to 60% without (p = 0.096); however, this association demonstrated only a statistical tendency. Multivariate analysis identified clinical stage and adjuvant chemotherapy use as independent factors contributing to survival. Conclusions: This study underscores matted nodes as potential prognostic indicators in CC, emphasizing their association with higher pN stage and reduced survival. Although the patients with matted nodes showed lower survival, this figure did not search statistical significance, but a tendency was detected, which necessitates precise further research, which is essential for validating these findings and integrating matted nodes into the broader context of colorectal cancer management.

Background Cervical cancer (CC) is the fourth cause of mortality by neoplasia in women worldwide. The use of immunomarkers is an alternative tool to complement currently used algorithms for detection of cancer, and to improve selection of therapeutic schemes. Aberrant expression of Ezrin and E-cadherin play an important role in tumor invasion. In this study we analyzed Ezrin and E-cadherin expression in liquid-based cervical cytology samples, and evaluated their potential use as prognostic immunomarkers. Methods Immunocytochemical staining of Ezrin and E-cadherin was performed in cervical samples of 125 patients. The cytological or histological diagnostic was performed by Papanicolaou staining or H&E staining, respectively. HPV genotyping was determined using INNO-LIPA Genotyping Extra kit and the HPV physical status by in situ hybridization. Ezrin expression in HaCaT, HeLa and SiHa cell lines was determined by immunocytochemistry, immunofluorescence and Western blot. Results High Ezrin expression was observed in cervical cancer samples (70%), samples with multiple infection by HR-HPV (43%), and samples with integrated viral genome (47%). High Ezrin expression was associated with degree of SIL, viral genotype and physical status. In contrast, low E-cadherin expression was found in cervical cancer samples (95%), samples with multiple infection by HR-HPV/LR-HPV (87%) and integrated viral genome (72%). Low E-cadherin expression was associated with degree of SIL and viral genotype. Interestingly, Ezrin nuclear staining was associated with degree of SIL and viral genotype. High Ezrin expression, high percent of nuclear Ezrin and low E-cadherin expression behaved as risk factors for progression to HSIL and cervical cancer. Conclusions Ezrin and E-cadherin expression profile in cervical cytology samples could be a potential prognostic marker, useful for identifying cervical lesions with a high-risk of progression to cervical cancer.

Background The peri-adolescent period is a crucial developmental moment of transition from childhood to emergent adulthood. The present report analyses the differences in Power Spectrum (PS) of the Electroencephalogram (EEG) between late childhood (24 children between 8 and 13 years old) and young adulthood (24 young adults between 18 and 23 years old). Results The narrow band analysis of the Electroencephalogram was computed in the frequency range of 0–20 Hz. The analysis of mean and variance suggested that six frequency ranges presented a different rate of maturation at these ages, namely: low delta, delta-theta, low alpha, high alpha, low beta and high beta. For most of these bands the maturation seems to occur later in anterior sites than posterior sites. Correlational analysis showed a lower pattern of correlation between different frequencies in children than in young adults, suggesting a certain asynchrony in the maturation of different rhythms. The topographical analysis revealed similar topographies of the different rhythms in children and young adults. Principal Component Analysis (PCA) demonstrated the same internal structure for the Electroencephalogram of both age groups. Principal Component Analysis allowed to separate four subcomponents in the alpha range. All these subcomponents peaked at a lower frequency in children than in young adults. Conclusions The present approaches complement and solve some of the incertitudes when the classical brain broad rhythm analysis is applied. Children have a higher absolute power than young adults for frequency ranges between 0-20 Hz, the correlation of Power Spectrum (PS) with age and the variance age comparison showed that there are six ranges of frequencies that can distinguish the level of EEG maturation in children and adults. The establishment of maturational order of different frequencies and its possible maturational interdependence would require a complete series including all the different ages.

The design of earthquake-resistant structures depends greatly on the soil–foundation–structure interaction. This interaction is more complex in the presence of liquefiable soils. Pile and rigid inclusion systems represent a useful practice to support structures in the presence of liquefiable soils in seismic zones. Both systems increase the bearing capacity of soil and allow reducing the settlements in the structure. Numerical models with a 3-storey reinforced concrete frame founded on inclusions systems (soil–inclusion–platform–structure) and pile systems (soil–pile–structure) were analyzed. Finite difference numerical models were developed using Flac 3D. Two different soil profiles were considered. A simple constitutive model for liquefaction analysis that relates the volumetric strain increment to the cyclic shear strain amplitude was utilized to represent the behavior of the sand, and the linear elastic perfectly plastic constitutive model with a Mohr–Coulomb failure criterion was used to represent the behavior of the earth platform. Two earthquakes were used to study the influence of the different frequency of excitation in the systems. The results were presented in terms of maximum shear forces distribution in the superstructure and spectrum response of each system. The efforts and displacements in the rigid elements (piles or rigid inclusions) were compared for the different systems. The bending and buckling failure modes of the pile were examined. The results show that the pile system, the soil profile and the frequency of excitation have a great influence on the magnitude and location of efforts and displacements in the rigid elements.

Scaphanocephalus is a small trematode genus belonging to the family Opistorchiidae. The genus currently contains only three species associated with marine fish as intermediate hosts and fish-eating birds as definitive hosts. Here, specimens of Scaphanocephalus were collected from the Osprey, Pandion haliaetus, and the White mullet, Mugil curema in the Yucatán Peninsula, Mexico. We report for the first-time DNA sequences of adult specimens of Scaphanocephalus, particularly S. expansus, as well as a sequence of a different species sampled as metacercaria. Morphological comparisons of Scaphanocephalus expansus confirmed the identity of the adult specimens, with minor morphological variations; Scanning electron photomicrographs were included, and the species was re-described. Phylogenetic analysis based on 28S rDNA sequences showed that Scaphanocephalus is monophyletic within Opisthorchiidae and consists of three independent lineages. Sequences of adults are identical to those of S. expansus. Instead, the sequence of the metacercaria sampled from the mesentery of Mugil curema nested with specimens reported as Scaphanocephalus sp. from a labrid fish in the Mediterranean Sea, herein named it as Scaphanocephalus sp. 2.

Members of the genus Strigea Abildgaard, 1790 are endoparasites of birds distributed worldwide. Adults of an undescribed species of the genus Strigea were collected from the intestines of two hawk species (Rupornis magnirostris and Accipiter coperii). Other species identified as Parastrigea macrobursa that were described in Argentina were also recovered from two hawk species (Buteogallus urubitinga and Buteogallus anthracinus) in three localities along the coasts of Mexico. Specimens of the two species were sequenced for three molecular markers, the internal transcribed spacers locus (ITS1-5.8S rDNA- ITS2) and the domains D1–D3 from the large subunit from nuclear ribosomal DNA and the cytochrome c oxidase subunit 1 from mitochondrial DNA. The newly sequenced specimens were aligned with other strigeids sequences downloaded from GenBank. Maximum likelihood and Bayesian analyses inferred with each molecular marker revealed that our specimens of Strigea sp. formed an independent lineage, which is recognized herein as a new species, Strigea magnirostris n. sp., representing the first species in Mexico and the 16th in the Neotropical region. Morphologically, the new species is distinguished from other congeneric species from the Americas by having an oral sucker with several papillae around it, well-developed pseudosuckers (118–248 μm), a tegument covered with tiny spines, a larger cone genital (193–361 × 296–637) and a larger copulatory bursa (247–531 × 468–784). Our phylogenetic analyses revealed that P. macrobursa is not closely related to other members of the genus Parastrigea and is nested within Strigea, suggesting that P. macrobursa should be transferred to Strigea to form Strigea macrobursa n. comb., expanding its distribution range from Mexico to Argentina. Finally, the analyses also revealed that the taxonomy and systematics of Strigea should be re-evaluated, combining morphological and molecular characteristics.

The first science flight of the balloon-borne Sunrise telescope took place in June 2009 from ESRANGE (near Kiruna/Sweden) to Somerset Island in northern Canada. We describe the scientific aims and mission concept of the project and give an overview and a description of the various hardware components: the 1-m main telescope with its postfocus science instruments (the UV filter imager SuFI and the imaging vector magnetograph IMaX) and support instruments (image stabilizing and light distribution system ISLiD and correlating wavefront sensor CWS), the optomechanical support structure and the instrument mounting concept, the gondola structure and the power, pointing, and telemetry systems, and the general electronics architecture. We also explain the optimization of the structural and thermal design of the complete payload. The preparations for the science flight are described, including AIV and ground calibration of the instruments. The course of events during the science flight is outlined, up to the recovery activities. Finally, the in-flight performance of the instrumentation is discussed.