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Quantum Social Science
Written by world experts in the foundations of quantum mechanics and its applications to social science, this book shows how elementary quantum mechanical principles can be applied to decision-making paradoxes in psychology and used in modelling information in finance and economics. The book starts with a thorough overview of some of the salient differences between classical, statistical and quantum mechanics. It presents arguments on why quantum mechanics can be applied outside of physics and defines quantum social science. The issue of the existence of quantum probabilistic effects in psychology, economics and finance is addressed and basic questions and answers are provided. Aimed at researchers in economics and psychology, as well as physics, basic mathematical preliminaries and elementary concepts from quantum mechanics are defined in a self-contained way.
eBook
Chemometrics in Excel
Providing an easy explanation of the fundamentals, methods, and applications of chemometrics
•Acts as a practical guide to multivariate data analysis techniques
•Explains the methods used in Chemometrics and teaches the reader to perform all relevant calculations
•Presents the basic chemometric methods as worksheet functions in Excel
•Includes Chemometrics Add In for download which uses Microsoft Excel® for chemometrics training
•Online downloads includes workbooks with examples
eBook
Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells
Objectives:A gene–environment interaction between HLA-DR shared epitope genes and smoking in anti-cyclic citrullinated peptide antibody-positive rheumatoid arthritis (RA) has been reported. Identification of citrullinated proteins in bronchoalveolar lavage (BAL) cells from smokers has led to the suggestion that citrullination induced by smoking might be the first step in the pathogenic chain of RA.Objective:To confirm and extend these findings.Methods:Immunohistochemistry was performed on BAL cells and bronchial mucosal biopsy sections obtained through bronchoscopy from 14 healthy smokers and 16 healthy non-smokers. Two antibodies recognising citrullinated proteins, two antibodies recognising peptidylarginine deiminase (PAD)2 enzyme and one recognising PAD4 enzyme were used.Results:Citrullinated proteins are upregulated in BAL cells of healthy smokers compared with healthy non-smokers. This was associated with higher expression of the PAD2 enzyme. The same level of citrullinated proteins was present in bronchial mucosal biopsy specimens of healthy smokers and non-smokers, despite higher expression of PAD2 in smokers.Conclusion:This study provides evidence that smoking enhances PAD2 expression in the bronchial mucosal and alveolar compartment, with consequent generation of citrullinated proteins in the latter. Smoking is an environmental factor that may lead to citrulline autoimmunity in genetically susceptible subjects.
Journal Article
