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Steroidal glycoalkaloids (SGAs) such as α-solanine found in solanaceous food plants— as, for example, potato— are antinutritional factors for humans. Comparative coexpression analysis between tomato and potato coupled with chemical profiling revealed an array of 10 genes that partake in SGA biosynthesis. We discovered that six of them exist as a cluster on chromosome 7, whereas an additional two are adjacent in a duplicated genomic region on chromosome 12. Following systematic functional analysis, we suggest a revised SGA biosynthetic pathway starting from cholesterol up to the tetrasaccharide moiety linked to the tomato SGA aglycone. Silencing GLYCOALKALOID METABOLISM 4 prevented accumulation of SGAs in potato tubers and tomato fruit. This may provide a means for removal of unsafe, antinutritional substances present in these widely used food crops.

Purpose - The purpose of this paper is to investigate the impact of financial development, economic growth and energy consumption on environment degradation for Indian economy by using the time series data for the period 1971-2011. Design/methodology/approach - The stationary properties of the variables are checked by ADF, DF-GLS, PP and Ng-Perron unit root tests. The long-run relationship is examined by implementing the Autoregressive Distributed Lag bounds testing approach to co-integration and error correction method (ECM) is applied to examine the short-run dynamics. The direction of the causality is checked by VECM framework and variance decomposition is used to predict exogenous shocks of the variables. Findings - The empirical evidence confirms the existence of long-run relationship among the variables. Financial development appears to increase environmental degradation in India. The main contributors to environmental degradation are: economic growth, energy consumption financial development and urbanization. The results also lend support to the existence of environmental Kuznets curves for Indian economy. Research limitations/implications - The present study suggests that environmental degradation can be reduced at the cost of economic growth or energy efficient technologies should be encouraged to enhance the domestic product with the help of financial sector by improving environmental friendly technologies from advanced economies. Originality/value - This paper proposes to make a contribution to the existing literature through examining the relationship between financial development and environmental degradation in Indian economy during 1971-2011 by employing modern econometric techniques.

A deep understanding of neutrino-nucleus interaction is crucial for the precise measurement of neutrino oscillation parameters and cross section measurements. Various nuclear effects, such as initial state effects (IS) and final state interactions (FSI), make neutrino interactions more complicated. To probe the impacts of the nuclear effects, a separate study of FSI and IS is required. A set of variables known as centre-of-momentum (c.m.) variables ( θ c . m . and E c . m . ) provides a unique approach to isolate the FSI effect with minimal sensitivity to IS. This work presents the importance of c.m. variables in neutrino-induced eta ( η ) meson production in the DUNE near detector. θ c . m . is an important parameter to improve the FSI modeling, while E c . m . helps in isolating high-purity neutrino-Hydrogen events. The study of η production in neutrino interactions helps in understanding the theoretical descriptions of higher resonance states.

The construction industry is increasingly focused on sustainability, with a particular emphasis on reducing the environmental impact of cement production. One approach to this problem is to use recycled materials and explore eco-friendly raw materials, such as alumino-silicate by-products like fly ash, which can be used as raw materials for geopolymer concrete. To enhance the ductility, failure mode, and toughness of the geopolymer, researchers have added crumb rubber processed from scrap tires as partial replacement to fine aggregate of the geopolymer. Therefore, this study aims to develop rubberized geopolymer concrete (RGC) by partially replacing the fine aggregate with crumb rubber (CR). To optimize the mechanical properties of RGC, response surface methodology (RSM) has been used to develop 13 mixes with different levels and proportions of CR (10–30% partial replacement of fine aggregate by volume) and sodium hydroxide molarity (10–14 M) as input variables. The results showed that the strength properties increased as the molarity of NaOH increased, while the opposite trend was observed with CR. The maximum values for compressive strength, flexural strength, and uniaxial tensile strength were found to be 25 MPa, 3.1 MPa, and 0.41 MPa, respectively. Response surface models of the mechanical strengths, which were validated using ANOVA with high R2 values of 72–99%, have been developed. It has been found that using 10% CR with 14 M sodium hydroxide resulting in the best mechanical properties for RGC, which was validated with experimental tests. The result of the multi-objective optimization indicated that the optimum addition level for NaOH is 14 M, and the fine aggregate replacement level with CR is 10% in order to achieve a rubberized geopolymer suitable for structural applications.

Between 21 November and 22 December 2020, a SARS-CoV-2 community testing pilot took place in the South Wales Valleys. We conducted a case-control study in adults taking part in the pilot using an anonymous online questionnaire. Social, demographic and behavioural factors were compared in people with a positive lateral flow test (cases) and a sample of negatives (controls). A total of 199 cases and 2621 controls completed a questionnaire (response rates: 27.1 and 37.6% respectively). Following adjustment, cases were more likely to work in the hospitality sector (aOR 3.39, 95% CI 1.43–8.03), social care (aOR 2.63, 1.22–5.67) or healthcare (aOR 2.31, 1.29–4.13), live with someone self-isolating due to contact with a case (aOR 3.07, 2.03–4.62), visit a pub (aOR 2.87, 1.11–7.37) and smoke or vape (aOR 1.54, 1.02–2.32). In this community, and at this point in the epidemic, reducing transmission from a household contact who is self-isolating would have the biggest public health impact (population-attributable fraction: 0.2). As restrictions on social mixing are relaxed, hospitality venues will become of greater public health importance, and those working in this sector should be adequately protected. Smoking or vaping may be an important modifiable risk factor.

This paper examines the impact of financial development, economic growth and income inequality on poverty in India from 1970 to 2015 by employing the autoregressive distributed lag (ARDL) bounds testing procedure. The findings reveal a robust long-run relationship between financial development, economic growth, inequality and poverty. Results show that financial development and economic growth help in poverty reduction in India, whereas income inequality and inflation aggravate poverty. Empirical evidence of the Granger-causality test supports the presence of unidirectional causality from financial development and economic growth to poverty. Moreover, bidirectional causality exists between inequality and poverty. The present study provides evidence on which the policymakers may proceed with detailed investigation of how specific financial sector policies and interventions can be deployed as effective instruments for achieving favorable economic growth and income distribution. The study recommends that policies geared toward increasing financial development and economic growth should be adopted to reduce the high level of poverty and inequality currently prevailing in India.

Steels 9-12% Cr, having the high creep rupture strength are advocated for the modern low polluting thermal power plants. In the present investigation, the P91 pipe weldments have been characterized for microstructural responses in as-welded, post-weld heat treatment (PWHT) and ageing conditions. The PWHT of welded samples were carried out at 760 °C for time of 2 h and ageing at 760 °C for 720 h and 1440 h, respectively. The effect of time has been studied on precipitates size, distribution of precipitates and grain sizes present in various zones of P91 steel weldments. The impact toughness and hardness variation of heat affected zone (HAZ) have also been studied in as-welded condition as well as at different heat treatment condition. A significant change was observed in grain size and precipitates size after each heat treatment condition. The maximum impact toughness of HAZ was obtained after PWHT at 760 °C for 2 h. The main phase observed in weld fusion zone in as-welded, PWHT and ageing conditions were M 23 C 6 , MX, M 7 C 3 , Fe-rich M 3 C and M 2 C. The unwanted Z-phase (NbCrN) was also noticed in weld fusion zone after ageing of 1440 h.

Energy absorption by matter is fundamental to natural and man-made processes. However, despite this ubiquity, developing materials capable of withstanding severe energy fluxes without degradation is a significant challenge in materials science and engineering. Despite recent advances in creating alloys resistant to energy fluxes, mitigating the damage caused by the absorption and transfer of mechanical energy remains a critical obstacle in both fundamental science and technological applications. This challenge is especially prominent when the mechanical energy is transferred to the material by shock loading. This study demonstrates a phenomenon in which microstructurally stabilized nanocrystalline Cu-Ta alloys can undergo reversal or nearly complete recovery of the dislocation structure after multiple shock-loading impacts, unlike any other known metallic material. The microstructure of these alloys can withstand repeated shock-wave interactions at pressures up to 12 GPa without any significant microstructural damage or deterioration, demonstrating an extraordinary capacity to be virtually immune to the detrimental effects of shock loading. This study reveals that under 12 GPa shock loading, stabilized nanocrystalline Cu-3Ta can generate and reabsorb dislocations, enabling near-complete recovery without microstructural deterioration. This behavior contrasts with other known metals.

IntroductionAnxiety disorder affects nearly 9.4% of children aged 3-17 years.1 Virtual Reality (VR) provides an alternative for managing anxiety due to immersive, multisensory, and excellent distraction.ObjectivesThe aim is to evaluate the efficacy of VR therapy in managing anxiety in children.MethodsWe searched PubMed, Medline, Embase, Web of Science, and Biosisdatabases with the keywords “Virtual Reality” in the context of “AnxietyDisorders” and included 8 relevant studies published in English until February 10, 2023, for our qualitative synthesis.ResultsThe VR-Guided relaxation (VR-GR) effectively decreased anxiety immediately after administration. In another trial, 4 of the 9 patients completely overcame their fears, and 8 of 9 saw an improvement in target behaviors in the autism population even after six weeks after the therapy, and the effect lasted 1 year post-treatment. In another study, VR-based therapy helped reduce anxiety and behavioral scores significantly in the VR group vs. the control. In another study, they found during pediatric intravenous catheter placement, patients who received VR therapy showed significantly less anxiety and pain compared to those who did not. In another study, they found VR therapy helped reduce anxiety during the induction of pre-operative anesthesia in children undergoing elective surgery.ConclusionsA study discovered benefits with statistically significant results in reducing anxiety in children immediately after VR-based therapy. To explore the full spectrum of benefits and efficacy of VR-based therapy for anxiety as a standalone or adjunct to pharmacotherapy, we recommend future trials with robust study designs.Disclosure of InterestNone Declared

IntroductionAnorexia Nervosa (AN) is common in adolescents and has a high mortality and morbidity rate with a lifetime prevalence of 0.5% to 2%.1,2 We aim to review the neurobiology correlation of Anorexia Nervosa in Autism Spectrum Disorder as they are often associated together.Objectives1. Understand the correlation between the neurobiology of Autism Spectrum Disorder (ASD) and Anorexia Nervosa.2. Assess the association and prevalence of Anorexia nervosa in the ASD population.3. To focus on the implications for the pathogenesis of Anorexia Nervosa and treatment of this disorder in the ASD population.MethodsWe searched PubMed, APA PscyINFO, Embase, CINAHL, and Google scholar databases with the keywords Autism Spectrum Disorder AND Anorexia Nervosa and included 6 relevant human studies out of 187 published in English.ResultsNeilson et al. studied the outcome of ASD in teenage onset AN, and a statistically significant negative dose-response relationship is found in all the 3 Morgan-Russell Outcome Assessment Schedule (MROAS) domains in stable ASD over time, and the results on the subscales ‘mental state,’ ‘psychosexual state’ and ‘socio-economic state, “personal contacts,’ ‘social activities’ and ‘employment record.’3 The outcome of AN onset in adolescence is generally favorable regarding mortality and the persistence of eating disorders in adulthood. A study by Pruccoli et al. noted a high prevalence of ASD traits in a group of young AN patients, predominantly seen in 4 specific EDI-3 subscales and independent of BMI.4 Margari et al. found only AN diagnosis had a statistically significant difference (p = 0.04) in females vs. males when comparing sex differences for comorbidities.5ConclusionsMorphological changes in brain areas are linked to social cognition and increase the risk of eating disorders in ASD. We recommend future studies with robust study design to explore the full spectrum of pathogenesis and association of AN in ASD.Disclosure of InterestNone Declared