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الزيتون : التاريخ الكوني /
هذا الكتاب به تتقصى المؤلفة جذور الزيتون من العصور القديمة برشاقة وحيوية ناقلة القارئ من الأزمان السحيقة في بلاد ما بين النهرين إلى مائدة طعامنا في عالم اليوم لتستكشف تاريخ الزيتون الذي يكاد يكون بقدم البشرية نفسها إذ لا تبلغ شجرة الزيتون طاقتها الإنتاجية الكاملة إلا بعد مرور 35 سنة ويمكن أن تعمر لعدة قرون ودخلت تراثنا المكتوب وأصبحت جزءا من نظام الرموز لدينا فهي تنير صلواتنا وتثري ثقافتنا ونظامنا الغذائي معا.
Book
Rossby Waves in Astrophysics
Rossby waves are a pervasive feature of the large-scale motions of the Earth’s atmosphere and oceans. These waves (also known as planetary waves and r-modes) also play an important role in the large-scale dynamics of different astrophysical objects such as the solar atmosphere and interior, astrophysical discs, rapidly rotating stars, planetary and exoplanetary atmospheres. This paper provides a review of theoretical and observational aspects of Rossby waves on different spatial and temporal scales in various astrophysical settings. The physical role played by Rossby-type waves and associated instabilities is discussed in the context of solar and stellar magnetic activity, angular momentum transport in astrophysical discs, planet formation, and other astrophysical processes. Possible directions of future research in theoretical and observational aspects of astrophysical Rossby waves are outlined.
Journal Article
Cardiac syndrome X: a critical overview and future perspectives
The classic definition of cardiac syndrome X (CSX) seems inadequate both for clinical and research purposes and should be replaced with one aimed at including a sufficiently homogeneous group of patients with the common plausible pathophysiological mechanism of coronary microvascular dysfunction. More specifically, CSX should be defined as a form of stable effort angina, which, according to careful diagnostic investigation, can reasonably be attributed to abnormalities in the coronary microvascular circulation.
Journal Article
Autonomic cardiac function in children and adolescents with long COVID: a case-controlled study
Although the mechanisms underlying the pathophysiology of long COVID condition are still debated, there is growing evidence that autonomic dysfunction may play a role in the long-term complications or persisting symptoms observed in a significant proportion of patients after SARS-CoV-2 infection. However, studies focused on autonomic dysfunction have primarily been conducted in adults, while autonomic function has not yet been investigated in pediatric subjects. In this study, for the first time, we assessed whether pediatric patients with long COVID present abnormalities in autonomic cardiac function. Fifty-six long COVID pediatric patients (mean age 10.3 ± 3.8 y) and 27 age-, sex-, and body surface area-matched healthy controls (mean age 10.4 ± 4.5y) underwent a standard 12-lead electrocardiography (ECG) and 24-h ECG Holter monitoring. Autonomic cardiac function was assessed by time-domain and frequency-domain heart rate variability parameters. A comprehensive echocardiographic study was also obtained by two-dimensional echocardiography and tissue Doppler imaging. Data analysis showed that pediatric patients with long COVID had significant changes in HRV variables compared to healthy controls: significantly lower r-MSSD (root mean square of successive RR interval differences, 47.4 ± 16.9 versus 60.4 ± 29.1,
p
= 0.02), significant higher values VLF (very low frequency, 2077.8 ± 1023.3 versus 494.3 ± 1015.5 ms,
p
= 0.000), LF (low frequency, 1340.3 ± 635.6 versus 354.6 ± 816.8 ms,
p
= 0.000), and HF (high frequency, 895.7 ± 575.8 versus 278.9 ± 616.7 ms,
p
= 0.000). No significant differences were observed between the two groups both in systolic and diastolic parameters by echocardiography.
Conclusion
: These findings suggest that pediatric patients with long COVID have an imbalance of cardiac autonomic function toward a relative predominance of parasympathetic tone, as already reported in adult patients with long COVID. Further studies are needed to clarify the clinical significance of this autonomic dysfunction and demonstrate its role as a pathophysiological mechanism of long COVID, paving the way for effective therapeutic and preventive strategies.
What is Known:
• Long Covid in children has been described globally, but studies have mostly focused on collecting the temporal evolution of persisting symptoms.
What is New:
• Cardiac autonomic imbalance toward a relative predominance of parasympathetic tone is a mechanism underlying Long Covid in children, as also described in adults.
Journal Article
Quantitative analysis of myocardial blood flow in surgically revascularized and not revascularized myocardial segments. A pilot PET study
Purpose
To prospectively compare changes in myocardial blood flow (MBF) and myocardial flow reserve (MFR) in multivessel coronary artery disease (MVCAD) patients undergoing incomplete revascularization (IR) versus complete revascularization (CR) by coronary artery bypass grafting (CABG).
Methods
Seven male patients (age 68 ± 9 years) with MVCAD underwent myocardial perfusion PET/CT with [13N]ammonia before and at least 4 months after CABG. Segmental resting and stress MBF as well as MFR were measured. Resting and during stress left ventricle ejection fraction (LVEF) were also calculated.
Results
Three patients (43%) underwent CR and four (57%) IR. Among 119 myocardial segments, 101 (85%) were revascularized, and 18 (15%) were not. After CABG, stress MBF (mL/min/gr) and MFR are significantly increased in all myocardial segments, with a greater increase in the revascularized segments (
p
= 0.013). In both groups, LVEF significantly decreased during stress at baseline PET (
p
= 0.04), but not after CABG.
Conclusion
Stress MBF and MFR significantly improve after CABG in both revascularized and not directly revascularized myocardial segments. IR strategy may be considered in patients with high surgical risk for CR.
Journal Article
The Latino mortality paradox: a test of the \salmon bias\ and healthy migrant hypotheses
OBJECTIVES: Relative to non-Latino Whites, Latinos have a worse socioeconomic profile but a lower mortality rate, a finding that presents an epidemiologic paradox. This study tested the salmon bias hypothesis that Latinos engage in return migration to their country of origin and are thereby rendered \"statistically immortal\" and the alternative hypothesis that selection of healthier migrants to the United States accounts for the paradox. METHODS: National Longitudinal Mortality Study data were used to examine mortality rates of the following groups for whom the salmon hypothesis is not feasible: Cubans, who face barriers against return migration; Puerto Ricans, whose deaths in Puerto Rico are recorded in US national statistics; and US-born individuals, who are not subject to either salmon or healthy migrant effects. RESULTS: The sample included 301,718 non-Latino Whites and 17,375 Latino Whites 25 years or older. Cubans and Puerto Ricans had lower mortality than non-Latino Whites. Moreover, US-born Latinos had lower mortality than US-born non-Latino Whites. CONCLUSIONS: Neither the salmon nor the healthy migrant hypothesis explains the pattern of findings. Other factors must be operating to produce the lower mortality.
Journal Article
Experimental, Spectroscopic, and Computational Insights into the Reactivity of “Methanal” with 2-Naphthylamines
The reactions of 2-naphthylamine and methyl 6-amino-2-naphthoate with formalin and paraformaldehyde were studied experimentally, spectrally, and by quantum chemical calculations. It was found that neither the corresponding aminals nor imines were formed under the described conditions but could be prepared and spectrally characterized at least in situ under modified conditions. Several of the previously undescribed intermediates and by-products were isolated or at least spectrally characterized. First principle density functional theory (DFT) calculations were performed to shed light on the key aspects of the thermochemistry of decomposition and further condensation of the corresponding aminals and imines. The calculations also revealed that the electrophilicity of methanal was significantly greater than that of ordinary oxo-compounds, except for perfluorinated ones. In summary, methanal was not behaving as the simplest aldehyde but as a very electron-deficient oxo-compound.
Journal Article
The Role of Prevention in Promoting Continuity of Health Care in Prisoner Reentry Initiatives
Most incarcerated individuals will return to the community, and their successful reentry requires consideration of their health and how their health will affect their families and communities. We propose the use of a prevention science framework that integrates universal, selective, and indicated strategies to facilitate the successful reentry of men released from prison. Understanding how health risks and disparities affect the transition from prison to the community will enhance reentry intervention efforts. To explore the application of the prevention rubric, we evaluated a community-based prisoner reentry initiative. The findings challenge all involved in reentry initiatives to reconceptualize prisoner reentry from a program model to a prevention model that considers multilevel risks to and facilitators of successful reentry.
Journal Article
Tides and angular momentum redistribution inside low-mass stars hosting planets: a first dynamical model
We introduce a general mathematical framework to model the internal transport of angular momentum in a star hosting a close-in planetary/stellar companion. By assuming that the tidal and rotational distortions are small and that the deposit/extraction of angular momentum induced by stellar winds and tidal torques are redistributed solely by an effective eddy-viscosity that depends on the radial coordinate, we can formulate the model in a completely analytic way. It allows us to compute simultaneously the evolution of the orbit of the companion and of the spin and the radial differential rotation of the star. An illustrative application to the case of an F-type main-sequence star hosting a hot Jupiter is presented. The general relevance of our model to test more sophisticated numerical dynamical models and to study the internal rotation profile of exoplanet hosts, submitted to the combined effects of tides and stellar winds, by means of asteroseismology are discussed.
Journal Article
Role of continuous glucose monitoring in diabetic patients at high cardiovascular risk: an expert-based multidisciplinary Delphi consensus
Background
Continuous glucose monitoring (CGM) shows in more detail the glycaemic pattern of diabetic subjects and provides several new parameters (“glucometrics”) to assess patients’ glycaemia and consensually guide treatment. A better control of glucose levels might result in improvement of clinical outcome and reduce disease complications. This study aimed to gather an expert consensus on the clinical and prognostic use of CGM in diabetic patients at high cardiovascular risk or with heart disease.
Methods
A list of 22 statements concerning type of patients who can benefit from CGM, prognostic impact of CGM in diabetic patients with heart disease, CGM use during acute cardiovascular events and educational issues of CGM were developed. Using a two-round Delphi methodology, the survey was distributed online to 42 Italian experts (21 diabetologists and 21 cardiologists) who rated their level of agreement with each statement on a 5-point Likert scale. Consensus was predefined as more than 66% of the panel agreeing/disagreeing with any given statement.
Results
Forty experts (95%) answered the survey. Every statement achieved a positive consensus. In particular, the panel expressed the feeling that CGM can be prognostically relevant for every diabetic patient (70%) and that is clinically useful also in the management of those with type 2 diabetes not treated with insulin (87.5%). The assessment of time in range (TIR)
,
glycaemic variability (GV) and hypoglycaemic/hyperglycaemic episodes were considered relevant in the management of diabetic patients with heart disease (92.5% for TIR, 95% for GV, 97.5% for time spent in hypoglycaemia) and can improve the prognosis of those with ischaemic heart disease (100% for hypoglycaemia, 90% for hyperglycaemia) or with heart failure (87.5% for hypoglycaemia, 85% for TIR, 87.5% for GV). The experts retained that CGM can be used and can impact the short- and long-term prognosis during an acute cardiovascular event. Lastly, CGM has a recognized educational role for diabetic subjects.
Conclusions
According to this Delphi consensus, the clinical and prognostic use of CGM in diabetic patients at high cardiovascular risk is promising and deserves dedicated studies to confirm the experts’ feelings.
Journal Article