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Probably because of their interpretability and transparent nature, synthetic controls have become widely applied in empirical research in economics and the social sciences. This article aims to provide practical guidance to researchers employing synthetic control methods. The article starts with an overview and an introduction to synthetic control estimation. The main sections discuss the advantages of the synthetic control framework as a research design, and describe the settings where synthetic controls provide reliable estimates and those where they may fail. The article closes with a discussion of recent extensions, related methods, and avenues for future research.

In recent years, a widespread consensus has emerged about the necessity of establishing bridges between quantitative and qualitative approaches to empirical research in political science. In this article, we discuss the use of the synthetic control method as a way to bridge the quantitative/qualitative divide in comparative politics. The synthetic control method provides a systematic way to choose comparison units in comparative case studies. This systematization opens the door to precise quantitative inference in small-sample comparative studies, without precluding the application of qualitative approaches. Borrowing the expression from Sidney Tarrow, the synthetic control method allows researchers to put \"qualitative flesh on quantitative bones.\" We illustrate the main ideas behind the synthetic control method by estimating the economic impact of the 1990 German reunification on West Germany.

Program evaluation methods are widely applied in economics to assess the effects of policy interventions and other treatments of interest. In this article, we describe the main methodological frameworks of the econometrics of program evaluation. In the process, we delineate some of the directions along which this literature is expanding, discuss recent developments, and highlight specific areas where new research may be particularly fruitful.

Consider a researcher estimating the parameters of a regression function based on data for all 50 states in the United States or on data for all visits to a website. What is the interpretation of the estimated parameters and the standard errors? In practice, researchers typically assume that the sample is randomly drawn from a large population of interest and report standard errors that are designed to capture sampling variation. This is common even in applications where it is difficult to articulate what that population of interest is, and how it differs from the sample. In this article, we explore an alternative approach to inference, which is partly design-based. In a design-based setting, the values of some of the regressors can be manipulated, perhaps through a policy intervention. Design-based uncertainty emanates from lack of knowledge about the values that the regression outcome would have taken under alternative interventions. We derive standard errors that account for design-based uncertainty instead of, or in addition to, sampling-based uncertainty. We show that our standard errors in general are smaller than the usual infinite-population sampling-based standard errors and provide conditions under which they coincide.

Building on an idea in Abadie and Gardeazabal (2003), this article investigates the application of synthetic control methods to comparative case studies. We discuss the advantages of these methods and apply them to study the effects of Proposition 99, a large-scale tobacco control program that California implemented in 1988. We demonstrate that, following Proposition 99, tobacco consumption fell markedly in California relative to a comparable synthetic control region. We estimate that by the year 2000 annual per-capita cigarette sales in California were about 26 packs lower than what they would have been in the absence of Proposition 99. Using new inferential methods proposed in this article, we demonstrate the significance of our estimates. Given that many policy interventions and events of interest in social sciences take place at an aggregate level (countries, regions, cities, etc.) and affect a small number of aggregate units, the potential applicability of synthetic control methods to comparative case studies is very large, especially in situations where traditional regression methods are not appropriate.

In Abadie and Imbens (2006), it was shown that simple nearest-neighbor matching estimators include a conditional bias term that converges to zero at a rate that may be slower than N 1/2 . As a result, matching estimators are not N 1/2 -consistent in general. In this article, we propose a bias correction that renders matching estimators N 1/2 -consistent and asymptotically normal. To demonstrate the methods proposed in this article, we apply them to the National Supported Work (NSW) data, originally analyzed in Lalonde (1986). We also carry out a small simulation study based on the NSW example. In this simulation study, a simple implementation of the bias-corrected matching estimator performs well compared to both simple matching estimators and to regression estimators in terms of bias, root-mean-squared-error, and coverage rates. Software to compute the estimators proposed in this article is available on the authors' web pages ( http://www.economics.harvard.edu/faculty/imbens/software.html ) and documented in Abadie et al. (2003).

This article considers the problem of assessing the distributional consequences of a treatment on some outcome variable of interest when treatment intake is (possibly) nonrandomized, but there is a binaryinstrument available for the researcher. Such a scenario is common in observational studies and in randomized experiments with imperfect compliance. One possible approach to this problem is to compare the counterfactual cumulative distribution functions of the outcome with and without the treatment. This article shows how to estimate these distributions using instrumental variable methods and a simple bootstrap procedure is proposed to test distributional hypotheses, such as equality of distributions, first-order and second-order stochastic dominance. These tests and estimators are applied to the study of the effects of veteran status on the distribution of civilian earnings. The results show a negative effect of military service during the Vietnam era that appears to be concentrated on the lower tail of the distribution of earnings. First-order stochastic dominance cannot be rejected by the data.

Matching estimators for average treatment effects are widely used in evaluation research despite the fact that their large sample properties have not been established in many cases. The absence of formal results in this area may be partly due to the fact that standard asymptotic expansions do not apply to matching estimators with a fixed number of matches because such estimators are highly nonsmooth functionals of the data. In this article we develop new methods for analyzing the large sample properties of matching estimators and establish a number of new results. We focus on matching with replacement with a fixed number of matches. First, we show that matching estimators are not N1/2-consistent in general and describe conditions under which matching estimators do attain N1/2-consistency. Second, we show that even in settings where matching estimators are N1/2-consistent, simple matching estimators with a fixed number of matches do not attain the semiparametric efficiency bound. Third, we provide a consistent estimator for the large sample variance that does not require consistent nonparametric estimation of unknown functions. Software for implementing these methods is available in Matlab, Stata, and R.

This article investigates the economic effects of conflict, using the terrorist conflict in the Basque Country as a case study. We find that, after the outbreak of terrorism in the late 1960's, per capita GDP in the Basque Country declined about 10 percentage points relative to a synthetic control region without terrorism. In addition, we use the 1998-1999 truce as a natural experiment. We find that stocks of firms with a significant part of their business in the Basque Country showed a positive relative performance when truce became credible, and a negative relative performance at the end of the cease-fire.

After the 9/11 attacks, much of the political and media debate on terrorism has focused on prevention policies. The widespread view that poverty creates terrorism has dominated much of this debate. This is hardly surprising. After all, the notion that poverty generates terrorism is consistent with the results of most of the literature on the economics of conflicts. Because terrorism is a manifestation of political conflict, these results seem to indicate that poverty and adverse economic conditions may play an important role in explaining terrorism. Recent empirical studies, however, have challenged the view that poverty creates terrorism. Using US State Department data on transnational terrorist attacks, Alan B. Krueger and David L. Laitin and James A. Piazza find no evidence suggesting poverty may generate terrorism. Conversely, among countries with similar levels of civil liberties, richer countries seem to be preferred targets for transnational terrorist attacks. However, these studies may suffer, in principle, from some potential shortcomings.