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"Abdullah, Ahmed"
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Unity of the religions in knowing of al-dayyan (Allah)
This scholarly work explores the concept of Monotheism (Tawhid) from a comparative and universal perspective, focusing on the core essence of divinity as represented by the Name of God, \"Al-Dayyan\" (The Judge, The Requiter, The Governor). The author, Ahmed Mohammed Abdullah Awadh, argues that despite the diversity of religious practices and historical contexts, there is an underlying \"Unity of Religion\" regarding the knowledge and recognition of the Creator.
BOOK
A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells
The stabilisation of G-quadruplexes (G4s) by small-molecule compounds is an effective approach for causing cell growth arrest, followed by cell death. Some of these compounds are currently being developed for the treatment of human cancers. We have previously developed a substituted naphthalene diimide G4-binding molecule (CM03) with selective potency for pancreatic cancer cells, including gemcitabine-resistant cells. We report here that CM03 and the histone deacetylase (HDAC) inhibitor SAHA (suberanilohydroxamic acid) have synergistic effects at concentrations close to and below their individual GI50 values, in both gemcitabine-sensitive and resistant pancreatic cancer cell lines. Immunoblot analysis showed elevated levels of γ-H2AX and cleaved PARP proteins upon drug combination treatment, indicating increased levels of DNA damage (double-strand break events: DSBs) and apoptosis induction, respectively. We propose that the mechanism of synergy involves SAHA relaxing condensed chromatin, resulting in higher levels of G4 formation. In turn, CM03 can stabilise a greater number of G4s, leading to the downregulation of more G4-containing genes as well as a higher incidence of DSBs due to torsional strain on DNA and chromatin structure.
Journal Article
Correction: Men’s knowledge, attitude, and barriers towards emergency contraception: A facility based cross-sectional study at King Saud University Medical City
[This corrects the article DOI: 10.1371/journal.pone.0249292.].
Journal Article
Research progress, models and simulation of electrospinning technology: a review
In recent years, nanomaterials have aroused extensive research interest in the world's material science community. Electrospinning has the advantages of wide range of available raw materials, simple process, small fiber diameter and high porosity. Electrospinning as a nanomaterial preparation technology with obvious advantages has been studied, such as its influencing parameters, physical models and computer simulation. In this review, the influencing parameters, simulation and models of electrospinning technology are summarized. In addition, the progresses in applications of the technology in biomedicine, energy and catalysis are reported. This technology has many applications in many fields, such as electrospun polymers in various aspects of biomedical engineering. The latest achievements in recent years are summarized, and the existing problems and development trends are analyzed and discussed.
Journal Article
Development of a video tampering dataset for forensic investigation
Due to the limited resources in digital video datasets, a new dataset of video tampering is proposed.Three different techniques of videos tampering are considered in this work, one of these techniques (splicing) is never been used in the existing dataset.This work provides a great opportunity to the researchers in video tampering area to evaluate their methods by designing and developing a ground truth
Forgery is an act of modifying a document, product, image or video, among other media. Video tampering detection research requires an inclusive database of video modification. This paper aims to discuss a comprehensive proposal to create a dataset composed of modified videos for forensic investigation, in order to standardize existing techniques for detecting video tampering. The primary purpose of developing and designing this new video library is for usage in video forensics, which can be consciously associated with reliable verification using dynamic and static camera recognition. To the best of the author⿿s knowledge, there exists no similar library among the research community. Videos were sourced from YouTube and by exploring social networking sites extensively by observing posted videos and rating their feedback. The video tampering dataset (VTD) comprises a total of 33 videos, divided among three categories in video tampering: (1) copy⿿move, (2) splicing, and (3) swapping-frames. Compared to existing datasets, this is a higher number of tampered videos, and with longer durations. The duration of every video is 16s, with a 1280ÿ720 resolution, and a frame rate of 30 frames per second. Moreover, all videos possess the same formatting quality (720pHD.avi). Both temporal and spatial video features were considered carefully during selection of the videos, and there exists complete information related to the doctored regions in every modified video in the VTD dataset. This database has been made publically available for research on splicing, Swapping frames, and copy⿿move tampering, and, as such, various video tampering detection issues with ground truth. The database has been utilised by many international researchers and groups of researchers.
Journal Article
Computational screening and in vitro evaluation of sphingosine-1-phosphate analogues as therapeutics for Non-Hodgkin’s lymphoma
Non-Hodgkin’s lymphoma (NHL) is a prevalent hematological malignancy that includes a variety of B-cell and T-cell proliferations. The S1P (sphingosine-1-phosphate) pathway, involved in cell survival, proliferation, and migration, plays a critical role in NHL pathogenesis. Targeting S1PR1, the receptor for S1P, may provide a therapeutic strategy for NHL. The primary objective of this study was to identify and evaluate the efficacy of S1P analogues against the S1PR1 receptor through computational methods and experimental validation. The crystal structure of S1PR1 was obtained from the Protein Data Bank, and computational methods, including molecular docking, QSAR modeling, and machine learning techniques, were employed to screen 779 S1P analogues. The most promising compounds were further analyzed through molecular dynamics simulations. In vitro, Raji cells were treated with the potent analogue CHEMBL1540377. MTT assay and colony formation assays were used to evaluate cell viability and proliferation. Additionally, apoptosis and necrosis were assessed by AO/EB staining. Computational studies identified several analogues with high binding affinities to S1PR1, including CHEMBL1540377. Molecular dynamics simulations confirmed the stability and binding of CHEMBL1540377 with S1PR1. In vitro assays demonstrated that CHEMBL1540377 significantly reduced cell viability and inhibited colony formation in Raji cells. AO/EB staining revealed that the compound induced both apoptosis and necrosis in the treated cells. This study identifies CHEMBL1540377 as a potent analogue targeting S1PR1 for NHL therapy. The combination of computational and experimental findings provides a strong foundation for future research and potential clinical application of S1P analogues in treating NHL.
Journal Article
Effect of Calcination Temperature and Time on the Synthesis of Iron Oxide Nanoparticles: Green vs. Chemical Method
Nowadays, antioxidants and antibacterial activity play an increasingly vital role in biosystems due to the biochemical and biological reactions that involve free radicals and pathogen growth, which occur in many systems. For this purpose, continuous efforts are being made to minimize these reactions, including the use of nanomaterials as antioxidants and bactericidal agents. Despite such advances, iron oxide nanoparticles still lack knowledge regarding their antioxidant and bactericidal capacities. This includes the investigation of biochemical reactions and their effects on nanoparticle functionality. In green synthesis, active phytochemicals give nanoparticles their maximum functional capacity and should not be destroyed during synthesis. Therefore, research is required to establish a correlation between the synthesis process and the nanoparticle properties. In this sense, the main objective of this work was to evaluate the most influential process stage: calcination. Thus, different calcination temperatures (200, 300, and 500 °C) and times (2, 4, and 5 h) were studied in the synthesis of iron oxide nanoparticles using either Phoenix dactylifera L. (PDL) extract (green method) or sodium hydroxide (chemical method) as the reducing agent. The results show that calcination temperatures and times had a significant influence on the degradation of the active substance (polyphenols) and the final structure of iron oxide nanoparticles. It was found that, at low calcination temperatures and times, the nanoparticles exhibited small sizes, fewer polycrystalline structures, and better antioxidant activities. In conclusion, this work highlights the importance of green synthesis of iron oxide nanoparticles due to their excellent antioxidant and antimicrobial activities.
Journal Article