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\"Looking through the ages and across the globe, [the authors] have reclaimed the stories of twenty-five remarkable women who dared to defy history and change the world around them. From Mongolian wrestlers to Chinese pirates, Native American ballerinas to Egyptian scientists, Japanese novelists to British Prime Ministers, [this book] will reframe the history that you thought you knew\"--Provided by publisher.

Circular RNAs (circRNAs) are stable and prevalent RNAs in eukaryotic cells that arise from back-splicing. Synthetic circRNAs and some endogenous circRNAs can encode proteins, raising the promise of circRNA as a platform for gene expression. In this study, we developed a systematic approach for rapid assembly and testing of features that affect protein production from synthetic circRNAs. To maximize circRNA translation, we optimized five elements: vector topology, 5′ and 3′ untranslated regions, internal ribosome entry sites and synthetic aptamers recruiting translation initiation machinery. Together, these design principles improve circRNA protein yields by several hundred-fold, provide increased translation over messenger RNA in vitro, provide more durable translation in vivo and are generalizable across multiple transgenes. Protein expression from circular RNAs is enhanced several hundred-fold by optimizing vector design.

A long-standing crucial question with atomic nuclei is whether or not α clustering occurs there. An α particle (helium-4 nucleus) comprises two protons and two neutrons, and may be the building block of some nuclei. This is a very beautiful and fascinating idea, and is indeed plausible because the α particle is particularly stable with a large binding energy. However, direct experimental evidence has never been provided. Here, we show whether and how α (-like) objects emerge in atomic nuclei, by means of state-of-the-art quantum many-body simulations formulated from first principles, utilizing supercomputers including K/Fugaku. The obtained physical quantities exhibit agreement with experimental data. The appearance and variation of the α clustering are shown by utilizing density profiles for the nuclei beryllium-8, -10 and carbon-12. With additional insight by statistical learning, an unexpected crossover picture is presented for the Hoyle state, a critical gateway to the birth of life. Alpha particles are considered the building blocks for some nuclei in alpha-clustering. Here the authors discuss quantum many-body simulations with nucleon-nucleon interaction to characterize the Hoyle state, the first excited 0+ state of the 12C nucleus, and find complexity in its alpha-clustering.

Many studies of visual processing are conducted in constrained conditions such as head- and gaze-fixation, and therefore less is known about how animals actively acquire visual information in natural contexts. To determine how mice target their gaze during natural behavior, we measured head and bilateral eye movements in mice performing prey capture, an ethological behavior that engages vision. We found that the majority of eye movements are compensatory for head movements, thereby serving to stabilize the visual scene. During movement, however, periods of stabilization are interspersed with non-compensatory saccades that abruptly shift gaze position. Notably, these saccades do not preferentially target the prey location. Rather, orienting movements are driven by the head, with the eyes following in coordination to sequentially stabilize and recenter the gaze. These findings relate eye movements in the mouse to other species, and provide a foundation for studying active vision during ethological behaviors in the mouse. As you read this sentence, your eyes will move automatically from one word to the next, while your head remains still. Moving your eyes enables you to view each word using your central – as opposed to peripheral – vision. Central vision allows you to see objects in fine detail. It relies on a specialized area of the retina called the fovea. When you move your eyes across a page, you keep the images of the words you are currently reading on the fovea. This provides the detailed vision required for reading. The same process works for tracking moving objects. When watching a bird fly across the sky, you can track its progress by moving your eyes to keep the bird in the center of your visual field, over the fovea. But the majority of mammals do not have a fovea, and yet are still able to track moving targets. Think of a lion hunting a gazelle, for instance, or a cat stalking a mouse. Even mice themselves can track and capture insect prey such as crickets, despite not having a fovea. And yet, exactly how they do this is unknown. This is particularly surprising given that mice have long been used to study the neural basis of vision. By fitting mice with miniature head-mounted cameras, Michaiel et al. now reveal how the rodents track and capture moving crickets. It turns out that unlike animals with a fovea, mice do not use eye movements to track moving objects. Instead, when a mouse wants to look at something new, it moves its head to point at the target. The eyes then follow and ‘land’ on the target. In essence, head movements lead the way and the eyes catch up afterwards. These findings are consistent with the idea that mammals with large heads evolved eye movements to overcome the energy costs of turning the head whenever they want to look at something new. For small animals, moving the head is less energetically expensive. As a result, being able to move the eyes independent of the head is unnecessary. Future work could use a combination of behavioral experiments and brain recordings to reveal how visual areas of the brain process what an animal is seeing in real time.

In natural contexts, sensory processing and motor output are closely coupled, which is reflected in the fact that many brain areas contain both sensory and movement signals. However, standard reductionist paradigms decouple sensory decisions from their natural motor consequences, and head-fixation prevents the natural sensory consequences of self-motion. In particular, movement through the environment provides a number of depth cues beyond stereo vision that are poorly understood. To study the integration of visual processing and motor output in a naturalistic task, we investigated distance estimation in freely moving mice. We found that mice use vision to accurately jump across a variable gap, thus directly coupling a visual computation to its corresponding ethological motor output. Monocular eyelid suture did not affect gap jumping success, thus mice can use cues that do not depend on binocular disparity and stereo vision. Under monocular conditions, mice altered their head positioning and performed more vertical head movements, consistent with a shift from using stereopsis to other monocular cues, such as motion or position parallax. Finally, optogenetic suppression of primary visual cortex impaired task performance under both binocular and monocular conditions when optical fiber placement was localized to binocular or monocular zone V1, respectively. Together, these results show that mice can use monocular cues, relying on visual cortex, to accurately judge distance. Furthermore, this behavioral paradigm provides a foundation for studying how neural circuits convert sensory information into ethological motor output.

We aimed to investigate whether combination assessment of phase angle (PhA) and skeletal muscle index (SMI), was a possible predictor of physical function at discharge from the hospital in patients with acute stroke. In this retrospective cohort study that was conducted from May 2020 and July 2021, we determined PhA and SMI using bioimpedance analysis (BIA) in patients with acute stroke. Patients were classified as normal, low PhA + SMI group, pre-sarcopenia (low SMI only), and dynapenia (low PhA only) using cut-off points (men: SMI < 7.0 kg/m2, PhA < 4.05 degrees; women: SMI < 5.7 kg/m2, PhA < 3.55 degrees). The main outcome was physical function based on functional independence measure motor (FIM-motor) score at discharge. Multiple regression analysis was used to determine the association between low PhA + SMI and FIM-motor score. We included 244 patients (161 men; mean age, 73.9 years). low PhA + SMI was found in 21 (8.6%) patients. Multiple regression analysis showed that low PhA + SMI was independently associated with the FIM-motor score at discharge (β= −0.099, 95%CI: −0.193,−0.005, p = 0.039). The PhA cutoff values for determining good functional results using receiver operating characteristic (ROC) curves were 5.36 for men (sensitivity = 0.769, specificity = 0.586, area under the curve [AUC] = 0.682), and 3.85 for women (sensitivity = It was 0.881, specificity = 0.481, AUC). Further, pearson correlation coefficient showed that PhA was significantly related to FIM-motor score in patients with mild or moderately severe stroke (mild: r = 0.472, p < 0.001; moderate: r = 0.524, p < 0.001). Combination of low PhA and SMI values at baseline, was an independent predictor of physical function at discharge in patients with acute stroke. The findings highlighted the importance of measuring PhA and SMI using BIA in patients with acute stroke.

Virtually any object can rotate: the rotation of a rod or a linear molecule appears evident, but a number of objects, including a simple example of H 2 O molecule, are of complex shapes and their rotation is of great interest. For atomic nuclei, rotational bands have been observed in many nuclei, and their basic picture is considered to have been established in the 1950s. We, however, show that there may be substantial changes in the basic picture of nuclear rotation: In the traditional view, as stressed by Aage Bohr in his Nobel lecture with an example of 166 Er nucleus, a large fraction of heavy (mass number A > 150 ) nuclei are like axially-symmetric prolate ellipsoids (i.e., with two shorter axes of equal length), rotating about one of the short axes, like a rod. In an alternative picture, however, the lengths of these three axes are all different, called triaxial. The triaxial shape yields more complex rotations. This alternative picture was also discussed in the past, but has not been recognized as a major picture. We show that substantially triaxial shapes occur in a large number of heavy deformed nuclei. Such prevailing triaxiality results in salient descriptions of experimental data over many nuclei, as confirmed by state-of-the-art Configuration Interaction calculations. Two origins are suggested for the triaxiality in the heavy deformed nuclei: (i) binding-energy gain by the symmetry restoration for triaxial shapes, and (ii) another gain by specific components of the nuclear force, like tensor force and high-multipole (e.g. hexadecupole) central force. While the origin (i) produces small triaxiality for virtually all deformed nuclei, the origin (ii) produces medium triaxiality for a certain class of nuclei. An example of the former is 154 Sm, a typical showcase of axial symmetry but is now suggested to depict a small yet finite triaxiality. The medium triaxiality is discussed from various viewpoints for some exemplified nuclei including 166 Er, and experimental findings, for instance, those by multiple Coulomb excitations decades ago, are re-evaluated to be supportive of the medium triaxiality. Many-body structures of the γ band and the double- γ band are clarified, and the puzzles over them are solved. The well-known J(J + 1)  -  K 2 formula of rotational excitation energies, which was derived by Taylor expansion in the past, is derived in an alternative way with polynomial property, including the previous work as an approximation. The rotational states of strongly and triaxially deformed heavy nuclei are described within quantum many-body framework, with K quantum number shown to be practically conserved. Thus, two long-standing open problems for strongly deformed heavy nuclei, (i) occurrence and origins of triaxial shapes and (ii) quantum many-body description of their rotational bands classified by K quantum number are solved. The picture of prevailing triaxial shapes thus emerges, where the empirically known rotational-band pattern appears with good K quantum number, but the internal structure is different from conventional picture à la A. Bohr. As a feasible experimental approach to the triaxiality of the 0 + ground state, the Relativistic Heavy-Ion Collision is mentioned. Davydov’s claim of triaxial shapes over many nuclei and the validity of his rigid-triaxial-rotor model are separately assessed with high appreciation of the former.

Good patient-doctor communication may help patients regulate their emotions, understand medical information, and assert their need for information and explanations. Cancer patients cited information needs as the most frequent unmet non-medical needs during oncological treatment. Adequate patient knowledge about the disease and treatment can affect the patient’s mental state, quality of life, and satisfaction with care. The study aimed to determine whether and what kind of cancer-related information is desired by cancer patients in Poland. The study was carried out on a group of 405 cancer patients using the Shortened Cassileth’s Information Styles Questionnaire (SCISQ) and Spielberg’s State-Trait Anxiety Inventory (STAI 20). Cancer patients in Poland want to receive information concerning numerous aspects of illness and treatment. Most patients wanted as much information about their disease and treatment as possible, both good and bad. Tumor localization (i.e., colorectal cancer, breast cancer), palliative intention of treatment, and low anxiety were factors increasing patients’ need for cancer information. Patients with low anxiety find it easier to express their needs and share information with others. Effective identification of information needs and non-delayed recognition and treatment of anxiety should be a part of a holistic approach to cancer care in daily clinical practice.

Background With nearly 1,100 species, the fish family Characidae represents more than half of the species of Characiformes, and is a key component of Neotropical freshwater ecosystems. The composition, phylogeny, and classification of Characidae is currently uncertain, despite significant efforts based on analysis of morphological and molecular data. No consensus about the monophyly of this group or its position within the order Characiformes has been reached, challenged by the fact that many key studies to date have non-overlapping taxonomic representation and focus only on subsets of this diversity. Results In the present study we propose a new definition of the family Characidae and a hypothesis of relationships for the Characiformes based on phylogenetic analysis of DNA sequences of two mitochondrial and three nuclear genes (4,680 base pairs). The sequences were obtained from 211 samples representing 166 genera distributed among all 18 recognized families in the order Characiformes, all 14 recognized subfamilies in the Characidae, plus 56 of the genera so far considered incertae sedis in the Characidae. The phylogeny obtained is robust, with most lineages significantly supported by posterior probabilities in Bayesian analysis, and high bootstrap values from maximum likelihood and parsimony analyses. Conclusion A monophyletic assemblage strongly supported in all our phylogenetic analysis is herein defined as the Characidae and includes the characiform species lacking a supraorbital bone and with a derived position of the emergence of the hyoid artery from the anterior ceratohyal. To recognize this and several other monophyletic groups within characiforms we propose changes in the limits of several families to facilitate future studies in the Characiformes and particularly the Characidae. This work presents a new phylogenetic framework for a speciose and morphologically diverse group of freshwater fishes of significant ecological and evolutionary importance across the Neotropics and portions of Africa.

Lath martensite is the dominant microstructural feature in quenched low-carbon Fe-C alloys. Its formation mechanism is not clear, despite extensive research. The microstructure of an Fe-0.05 C (wt.%) alloy water-quenched at various austenitizing temperatures has been investigated using transmission electron microscopy and a novel lath formation mechanism has been proposed. Body-centered cubic {112}〈111〉-type twin can be retained inside laths in the samples quenched at temperatures from 1050 °C to 1200 °C. The formation mechanism of laths with a twin substructure has been explained based on the twin structure as an initial product of martensitic transformation. A detailed detwinning mechanism in the auto-tempering process has also been discussed, because auto-tempering is inevitable during the quenching of low-carbon Fe-C alloys. The driving force for the detwinning is the instability of ω-Fe(C) particles, which are located only at the twinning boundary region. The twin boundary can move through the ω ↔ bcc transition in which the ω phase region represents the twin boundary.