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Argentina
Lonely Planet's Argentina is your passport to the most relevant, up-to-date advice on what to see and skip, and what hidden discoveries await you. Watch enormous icebergs calve from Glaciar Perito Moreno, tour wineries and enjoy the finished product around Mendoza, and hike the rugged Fitz Roy Range for stunning mountain views - all with your trusted travel companion. Get to the heart of Argentina and begin your journey now!
Book
A protocol for the evaluation of the PneumoWave biosensor in supported accommodation settings: A study on feasibility and acceptability (RESCU-2)
People who overdose on opioids when they are alone or unmonitored are at heightened risk of death as other people do not know they should provide an emergency response. Wearable technology provides an opportunity to continuously measure respiratory function and ultimately send an alert if respiratory depression occurs.
This study evaluates the feasibility and acceptability of PneumoWave DC in UK homeless hostels or supported accommodation settings (equivalent to Housing First in the USA) for individuals at high risk of opioid overdose. The PneumoWave system consists of a wearable biosensor that is affixed to the chest and records chest motion and which, in future, could potentially provide early detection of respiratory depression and trigger overdose response.
RESCU-2 is a non-randomised, observational trial conducted in supported accommodation facilities across the UK. 50 participants who currently use opioids and live in homeless hostels in England and Scotland will wear the PneumoWave biosensor for varying periods to collect data over 2,000 participant-days. The biosensor will be linked via Bluetooth to a hub for continuous respiratory data collection. Self-reported drug use during the trial will be measured using drug diaries. Quantitative acceptability data will be measured using structured satisfaction surveys, while qualitative acceptability data will be obtained from interviews and focus groups with both residents and staff. Statistical analysis will include descriptive evaluation of feasibility outcomes, while qualitative data will undergo thematic analysis. The primary objectives of the study are: 1) feasibility of the study protocol within the hostel setting; 2) acceptability and usability of the device among people who use opioids and live in hostels; 3) acceptability of the device among staff who work in hostels and respond to overdose events. Primary outcomes are recruitment, total hours of usable data collected and successful recording of key outcome measures, among others. Trial registration: ISRCTN12060022.
Findings will inform the feasibility of future integration of chest biosensor technology into hostel settings, assessing participant adherence, usability, and acceptability among people who use substances and staff. Insights gained will support the design of future trials and further development of remote monitoring technologies for overdose prevention and response strategies.
Journal Article
The unique states of America : can't-miss experiences across the USA
\"Travel off the beaten path and into the heart of each state with our expert itineraries exploring some of the USA's finest art and culture, food and drink, history, sports, and family-friendly places. Get fascinating insights into unmissable sights, attractions, parks and more with Lonely Planet's expert commentary and stunning photography.\"--Provided by publisher.
Book
Protocol for a multicentre randomised controlled trial of the Pharmacy Homeless Outreach Engagement Non-medical and Independent Prescriber (PHOENIx) intervention for people facing severe and multiple disadvantages
IntroductionPeople experiencing severe and multiple disadvantage (SMD: homelessness, substance use and criminal offending) have multiple intersecting unmet health and social care needs and high mortality rates, often due to street-drug overdose. Pilot randomised controlled trials (RCTs) suggest an integrated, holistic, collaborative outreach intervention (Pharmacy Homeless Outreach Engagement Non-medical Independent Prescribing Rx (PHOENIx)) involving generalist-trained pharmacists, nurses or General Practitioners accompanied by staff from third sector homeless organisations may improve outcomes, including reducing overdose.MethodsMulticentre, parallel group, prospective RCT with parallel economic and process evaluation. Set in six areas of Scotland, UK, 378 adults with SMD will be recruited and randomised (stratified by setting and previous non-fatal overdoses) to PHOENIx intervention in addition to usual care (UC) or UC. Aiming to meet participants weekly for 9–15 months, PHOENIx teams assess and address health and social care needs while referring onwards as necessary, co-ordinating care with wider health and third sector teams. During a person-centred consultation, in the participants’ choice of venue, and taking account of the participant’s priorities, the NHS clinician may prescribe, de-prescribe and treat, for example, wound care, and refer to other health services as necessary. The third sector worker may help with welfare benefit applications, social prescribing or advocacy, for example, securing stable housing. Pairings of clinicians and third sector workers support the same participants. The primary outcome is time to first fatal/non-fatal street-drug overdose at nine months. Secondary endpoints include health-related quality of life, healthcare use and criminal justice encounters. A health economic evaluation will assess cost per quality adjusted life year of PHOENIx relative to standard care. A parallel qualitative process evaluation will explore the perceptions and experiences of PHOENIx, by participants, stakeholders and PHOENIx staff.AnalysisThe primary and other time-to-event secondary outcomes will be analysed by Cox proportional hazards regression.Ethics and disseminationIRAS number 345246, approved 23/10/2024 by North of Scotland Research Ethics Service. Results will be shared with participants, third sector homelessness organisations, health and social care partnerships, then peer-reviewed journals and conferences worldwide, from the first quarter of 2027.Trial registration numberISRCTN12234059 registered on 20/2/2025 (ISRCTN).
Journal Article
Envie de liberté? Organisez-vous
L'Intelligence Organisationnelle est une méthode globale d'organisation de la vie professionnelle et privée par divers outils de développement personnel. Mis en bouche par Aurélien Coussement, ce livre vous conte les péripéties de Franck, un journaliste sans histoire, qui découvre bien malgré lui les étonnants pouvoirs du cerveau humain. Envoyé pour un article dans une entreprise où visiblement personne n'est pris par le temps ou ne semble stressé, Franck, un journaliste tout ce qu'il y a de plus banal, décide d'enquêter et d'en savoir plus sur les agissements particuliers de ces étranges employés. Il part alors à la rencontre de divers personnages qui, tout naturellement, lui expliquent pourquoi et comment ils ont réussi à se départir des maladies liées au temps et au stress, auxquelles nous sommes tous confrontés quotidiennement. Avec l'aide du patron de cette boîte hors du commun, notre journaliste parvient, au fur et à mesure des pages, à dégager divers outils de développements personnels, principes de communication interpersonnelle et techniques (des lois simples, des principes faciles à comprendre et à appliquer) qui aideront tout un chacun à mieux appréhender notre rapport au temps et aux autres, afin de se sentir plus libre et l'esprit dégagé. Dans ce livre, nous vous invitons à visiter ou revisiter vos processus, vos croyances, vos excuses, et peut-être à porter un jugement critique sur vous-même. Mais aussi à découvrir, tester et utiliser différents outils de développement personnel qui vous aideront à mieux vous organiser, mieux communiquer, pour vivre mieux! Un guide pratique pour mieux gérer votre emploi du temps entre activité professionnelle et vie privée.
eBook
Birefringence in a Silicon Beamsplitter at 2um for Future Gravitational Wave Detectors
The next generation of gravitational wave detectors will move to cryogenic operation in order to reduce thermal noise and thermal distortion. This necessitates a change in mirror substrate with silicon being a good candidate. Birefringence is an effect that will degrade the sensitivity of a detector and is of greater concern in silicon due to its crystalline nature. We measure the birefringence in a float zone silicon beamsplitter since we expect there to be a large inherent birefringence due to the spatial dispersion effect. We observe that the birefringence varied between \\(3.44 \\pm 0.12 \\times 10^{-7}\\) and \\(1.63 \\pm 0.05 \\times 10^{-7}\\) and estimate the birefringence along the axis to be \\(1.64 \\pm 0.5 \\times 10^{-6}\\) at 2um. We demonstrate this effect and argue that it strengthens the case for 2um and silicon.
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