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"Adam, N"
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Targeting telomerase for cancer therapy
Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer cells which enables replicative immortality. In contrast, telomerase activity is silenced in most adult somatic cells. Thus, telomerase represents an attractive target for highly selective cancer therapeutics. However, development of telomerase inhibitors has been challenging and thus far there are no clinically approved strategies exploiting this cancer target. The discovery of prevalent mutations in the TERT promoter region in many cancers and recent advances in telomerase biology has led to a renewed interest in targeting this enzyme. Here we discuss recent efforts targeting telomerase, including immunotherapies and direct telomerase inhibitors, as well as emerging approaches such as targeting TERT gene expression driven by TERT promoter mutations. We also address some of the challenges to telomerase-directed therapies including potential therapeutic resistance and considerations for future therapeutic applications and translation into the clinical setting. Although much work remains to be done, effective strategies targeting telomerase will have a transformative impact for cancer therapy and the prospect of clinically effective drugs is boosted by recent advances in structural models of human telomerase.
Journal Article
Attachment theory in adult mental health : a guide to clinical practice
\"In the fifty years since its inception, John Bowlby's attachment theory has been powerfully influential on developmental psychology and, more recently, mental health. Bringing together the experience of a diverse range of mental health practitioners and researchers who routinely use attachment theory in their own work, Attachment Theory in Adult Mental Health provides a guide to using attachment theory in everyday practice. Adam N. Danquah and Katherine Berry present a wide-ranging and practical approach to the topic which includes studies on clinical practice, the provision of mental health services and accommodating intercultural perspectives. Section One covers the basics of attachment theory and practice. Section Two presents clinical problems and presentations including, among others, the treatment of depression, anxiety disorders, psychosis, personality disorder and eating disorders. Section Three addresses the needs of specific populations, discussing the influence of sociocultural factors like gender, ethnicity and age. Finally, Section Four examines the organisation and the practitioner, including using the theory to organise services and how individual therapists can integrate their own attachment histories into their approach. Including the most up-to-date theories and practice in the field, Attachment Theory in Adult Mental Health is ideal for psychologists and psychological therapists, counsellors, psychiatrists, occupational therapists, social workers and mental health service managers and commissioners\"--Provided by publisher.
Book
What demographic attributes do our digital footprints reveal? A systematic review
To what extent does our online activity reveal who we are? Recent research has demonstrated that the digital traces left by individuals as they browse and interact with others online may reveal who they are and what their interests may be. In the present paper we report a systematic review that synthesises current evidence on predicting demographic attributes from online digital traces. Studies were included if they met the following criteria: (i) they reported findings where at least one demographic attribute was predicted/inferred from at least one form of digital footprint, (ii) the method of prediction was automated, and (iii) the traces were either visible (e.g. tweets) or non-visible (e.g. clickstreams). We identified 327 studies published up until October 2018. Across these articles, 14 demographic attributes were successfully inferred from digital traces; the most studied included gender, age, location, and political orientation. For each of the demographic attributes identified, we provide a database containing the platforms and digital traces examined, sample sizes, accuracy measures and the classification methods applied. Finally, we discuss the main research trends/findings, methodological approaches and recommend directions for future research.
Journal Article
Heroes & villains of finance : the 50 most colourful characters in the history of finance
\"Explore history's titans of finance, and their lasting global impactHeroes and Villains of Finance is a fascinating dive into the history of money as an institution, highlighting the fifty most significant figures that, rightly or wrongly, are responsible for the financial landscape we live in today. From philosophers and bankers to fraudsters and academics, this book provides a striking introduction to the most remarkable characters in the history of finance. Their impact reaches far beyond the financial system itself, and has helped shape the course of human history. The economic systems of today would look very differently if it weren't for these innovators, thought leaders, storytellers, and rebels, and this captivating examination takes you inside their stories to understand their thinking, their background, their perspective, and their inspiration.People both inside and outside the world of finance are perpetually curious about the larger-than-life characters who built, shaped, and continue to populate the industry. Their actions, both positive and negative, are responsible for what we understand as finance today. This book provides a glimpse into the events and motivations that contributed to the industry's evolution. Learn how the Knights Templar became the first banking institution Examine the Rothschild family's pioneering use of financial instruments in order to safeguard their wealth from distrusting European monarchs Study the origins and evolution of the Ponzi scheme Realise how Reaganomics still affects the U.S. economy today The finance industry is always in the public eye, and it's one of the few places where the actions of a few -- or even a single person -- can ripple throughout large populations. Heroes and Villains of Finance gives you a closer look at the biggest names that had the biggest impact, for better or worse\"-- Provided by publisher.
Book
WHAT CAN WE LEARN WITH STATISTICAL TRUTH SERUM? DESIGN AND ANALYSIS OF THE LIST EXPERIMENT
Due to the inherent sensitivity of many survey questions, a number of researchers have adopted an indirect questioning technique known as the list experiment (or the item-count technique) in order to reduce dishonest or evasive responses. However, standard practice with the list experiment requires a large sample size, utilizes only a difference-in-means estimator, and does not provide a measure of the sensitive item for each respondent. This paper addresses all of these issues. First, the paper presents design principles for the standard list experiment (and the double list experiment) for the reduction of bias and variance as well as providing sample-size formulas for the planning of studies. Second, this paper proves that a respondent-level probabilistic measure for the sensitive item can be derived. This provides a basis for diagnostics, improved estimation, and regression analysis. The techniques in this paper are illustrated with a list experiment from the 2008–2009 American National Election Studies (ANES) Panel Study and an adaptation of this experiment.
Journal Article
Trauma systems therapy for children and teens
\"For too many traumatized children and their families, chronic stressors such as poverty, substance abuse, and family or community violence--coupled with an overburdened care system/m-/pose seemingly insurmountable barriers to treatment. This empowering book provides a user-friendly blueprint for making the most of limited resources to help those considered the \"toughest cases.\" Evidence-based strategies are presented for effectively integrating individualized treatment with services at the home, school, and community levels. Written in an accessible, modular format with reproducible forms and step-by-step guidelines for assessment and intervention, the approach is grounded in the latest knowledge about child traumatic stress. It has been recognized as a treatment of choice by state mental health agencies nationwide\"-- Provided by publisher.
Book
Identifying Judicial Empathy: Does Having Daughters Cause Judges to Rule for Women's Issues?
In this article, we consider whether personal relationships can affect the way that judges decide cases. To do so, we leverage the natural experiment of a child's gender to identify the effect of having daughters on the votes of judges. Using new data on the family lives of U.S. Courts of Appeals judges, we find that, conditional on the number of children a judge has, judges with daughters consistently vote in a more feminist fashion on gender issues than judges who have only sons. This result survives a number of robustness tests and appears to be driven primarily by Republican judges. More broadly, this result demonstrates that personal experiences influence how judges make decisions, and this is the first article to show that empathy may indeed be a component in how judges decide cases.
Journal Article
Between a Rock and a Hard Place: The Role of DA-Induced Tumor Fibrosis in Prolactinoma Management
Key Words: prolactinoma, fibrosis, surgery, bromocriptine, dopamine agonist
Journal Article