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Introduction: Increased levels of TNF-a in the blood after exercise can cause muscle pain. Objective: This study aims to analyze the potential of sea cucumber phytochemical compounds in reducing TNF-a levels after exercise. Methodology: This type of research is experimental research. Subject selection was carried out using the purposive sampling method. Next, the subjects were divided into two groups, namely the treatment group (K1) received sea cucumbers, and the control group (K2) received placebo. Sea cucumber is given in supplementation form at a dose of 500 mg. This study involved 16 healthy guys. The study's participants were between the ages of 20 and 25. Three days were dedicated to data collection, starting with the collection of information on the subjects' characteristics. Subjects were then instructed to warm up. Practice is done afterwards. The exercises carried out include weight training with maximum intensity. 24 hours after exercise, blood was taken for pre-test data to measure TNF-a levels. Then the samples were given placebo intervention and sea cucumber supplements based on their respective groups. 48 hours after exercise, blood was taken for post test data to measure TNF-a levels. Results: The results showed that sea cucumber supplementation after exercise was shown to significantly reduce TNF-α levels in healthy men p<0.05*. Discussion: The anti-inflammatory properties of sea cucumber can have a positive impact in reducing TNF-α levels after exercise. Conclusions: Sea cucumber supplementation at a dose of 500 mg was able to reduce TNF-α levels significantly. We recommend investigating the effect of sea cucumber supplementation on IL-6 levels in the future.

The purpose of this study was to analyze and prove the effect of curcumin on TNF-a levels, and pain intensity after high-intensity physical exercise. This experimental research uses pre and post control group design. Research subjects were selected using random sampling technique. Next, the subjects were divided into 2 groups, K1 given placebo and K2 was given curcumin at a dose of 400 mg. A total of 20 healthy men participated in this study who were selected based on inclusion and exclusion criteria. On the first day, all subjects collected data on the characteristics of the research subjects, then did a warm-up, and then the subjects did physical exercises in the form of squad exercises and leg presses with an intensity of 80-90% of their maximum ability. Exercise is done 4 sets of each form of exercise and rest between sets of about 1 minute. The second day, after 24 hours post-exercise, all subjects measured pain intensity and took pre-test blood samples to measure TNF-a levels, then administer interventions based on each group. Pain intensity was measured using a VAS. On the third day, after 48 hours post-exercise, all subjects measured pain intensity and took post-test blood samples to measure TNF-a levels. The results of this study reported that the group that was given curcumin after high-intensity physical exercise was able to significantly reduce levels of TNF-a, and pain intensity (*p<0.05) compared to the placebo group. Giving a dose of 400 mg of curcumin after high-intensity physical exercise can reduce TNF-a levels and pain intensity after high-intensity physical exercise. Because reduction in pain intensity after high-intensity exercise is necessary to support body function, we recommend the use of curcumin for individuals who actively exercise. For future studies, we suggest testing the effects of curcumin on other inflammatory biomarkers.

Introduction: Increased levels of TNF-a in the blood after exercise can cause muscle pain. Objective: This study aims to analyze the potential of sea cucumber phytochemical compounds in reducing TNF-a levels after exercise. Methodology: This type of research is experimental research. Subject selection was carried out using the purposive sampling method. Next, the subjects were divided into two groups, namely the treatment group (K1) received sea cucumbers, and the control group (K2) received placebo. Sea cucumber is given in supplementation form at a dose of 500 mg. This study involved 16 healthy guys. The study's participants were between the ages of 20 and 25. Three days were dedicated to data collection, starting with the collection of information on the subjects' characteristics. Subjects were then instructed to warm up. Practice is done afterwards. The exercises carried out include weight training with maximum intensity. 24 hours after exercise, blood was taken for pre-test data to measure TNF-a levels. Then the samples were given placebo intervention and sea cucumber supplements based on their respective groups. 48 hours after exercise, blood was taken for post test data to measure TNF-a levels. Results: The results showed that sea cucumber supplementation after exercise was shown to significantly reduce TNF-α levels in healthy men p<0.05*. Discussion: The anti-inflammatory properties of sea cucumber can have a positive impact in reducing TNF-α levels after exercise. Conclusions: Sea cucumber supplementation at a dose of 500 mg was able to reduce TNF-α levels significantly. We recommend investigating the effect of sea cucumber supplementation on IL-6 levels in the future.