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While phenomenal strides are being made on the technological front, the water industry lags behind other sectors in the adoption of innovative techniques. Contributing factors include long lifetimes and costs of previous water infrastructure, risk aversion due to public health concerns surrounding water access, and low financing for innovation. While many professionals see the need for innovation, they prefer traditional tried and tested routes. Regulations may be useful in accelerating the transition to sustainable technologies. Furthermore, the literature emphasizes the role of environmental, social, and political actors, as well as their interplay in realizing innovation in the water sector.

The agricultural industry could undergo significant changes due to the revolutionary potential of nanotechnology. Nanotechnology has a broad range of possible applications and advantages, including insect pest management using treatments based on nanoparticle insecticides. Conventional techniques, such as integrated pest management, are inadequate, and using chemical pesticides has negative consequences. As a result, nanotechnology would provide ecologically beneficial and effective alternatives for insect pest control. Considering the remarkable traits they exhibit, silver nanoparticles (AgNPs) are recognized as potential prospects in agriculture. Due to their efficiency and great biocompatibility, the utilization of biologically synthesized nanosilver in insect pest control has significantly increased nowadays. Silver nanoparticles have been produced using a wide range of microbes and plants, which is considered an environmentally friendly method. However, among all, entomopathogenic fungi (EPF) have the most potential to be used in the biosynthesis of silver nanoparticles with a variety of properties. Therefore, in this review, different ways to get rid of agricultural pests have been discussed, with a focus on the importance and growing popularity of biosynthesized nanosilver, especially silver nanoparticles made from fungi that kill insects. Finally, the review highlights the need for further studies so that the efficiency of bio-nanosilver could be tested for field application and the exact mode of action of silver nanoparticles against pests can be elucidated, which will eventually be a boon to the agricultural industry for putting a check on pest populations.

Agrobacterium-mediated transformation is one of the most commonly used genetic transformation method that involves transfer of foreign genes into target plants. Agroinfiltration, an Agrobacterium-based transient approach and the breakthrough discovery of CRISPR/Cas9 holds trending stature to perform targeted and efficient genome editing (GE). The predominant feature of agroinfiltration is the abolishment of Transfer-DNA (T-DNA) integration event to ensure fewer biosafety and regulatory issues besides showcasing the capability to perform transcription and translation efficiently, hence providing a large picture through pilot-scale experiment via transient approach. The direct delivery of recombinant agrobacteria through this approach carrying CRISPR/Cas cassette to knockout the expression of the target gene in the intercellular tissue spaces by physical or vacuum infiltration can simplify the targeted site modification. This review aims to provide information on Agrobacterium-mediated transformation and implementation of agroinfiltration with GE to widen the horizon of targeted genome editing before a stable genome editing approach. This will ease the screening of numerous functions of genes in different plant species with wider applicability in future.

Despite a preponderance of evidence and considerable resources, health and social inequities persist, and in many cases, are widening. These inequities are not simply the result of passive structural and economic conditions but are actively maintained through institutional processes, norms, and ideologies that uphold the status quo. Reform within health inequities research, policy, and health and social care practice is therefore critical to disrupting these entrenched systems and catalysing both bottom-up and top-down change. We aimed to develop agreement for an iterative set of guiding principles underpinning ways of working for a newly formed Health and Social Equity Collective comprising researchers, community leaders, policymakers, and health and care professionals, seeking to address inequity by identifying and engaging the levers of change within and across institutions. The principles aim to inform a more inclusive and translational knowledge base through research practices, tackling entrenched inequalities in education, training, and capacity-building; and centring communities affected by health inequities through engagement and advocacy. We carried out a modified Delphi consensus process between March and September 2022 with Collective members and networks through online workshops and surveys. Out of 24 consensus statements developed and refined over a workshop and three successive survey rounds, we identified eleven key principles agreed upon by a majority of respondents. Two of these were rated high priority by over 75% of respondents, four by over 60% and five by over 50%. These could be grouped into three main topics detailing ways of working and change needed within: ‘Knowledge and framing of health and social inequities, and incorporation into practice’, ‘Community engagement, involvement and peer research’, and ‘Organisational culture change’, respectively. Given the pressing need to address inequities, these principles offer a grounding for future consensus building initiatives which also incorporate a wider diversity of perspectives, and which should be iteratively updated with ongoing learning from health equity initiatives nationally and internationally.

Rapid developments in the field of plant genome editing using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) systems necessitate more detailed consideration of the delivery of the CRISPR system into plants. Successful and safe editing of plant genomes is partly based on efficient delivery of the CRISPR system. Along with the use of plasmids and viral vectors as cargo material for genome editing, non-viral vectors have also been considered for delivery purposes. These non-viral vectors can be made of a variety of materials, including inorganic nanoparticles, carbon nanotubes, liposomes, and protein- and peptide-based nanoparticles, as well as nanoscale polymeric materials. They have a decreased immune response, an advantage over viral vectors, and offer additional flexibility in their design, allowing them to be functionalized and targeted to specific sites in a biological system with low cytotoxicity. This review is dedicated to describing the delivery methods of CRISPR system into plants with emphasis on the use of non-viral vectors.

Background Multiple educational modalities have been utilized including leaflet, face-to-face counseling and watching videos in waiting areas for engaging patients. Considering the two challenges of waiting time frustration and lack of health screening awareness, Family Physicians’ waiting area are an ideal place to bridge this gap. The objective of this study is to evaluate the effectiveness of video-based health education intervention in improving knowledge about health screening among patients and their families sitting in waiting area of Family Medicine clinics. Methods It was a pre and post quasi-experimental study that was conducted in family medicine clinics located at main campus and Outreach centers of a tertiary care hospital. A total of 300 participants were approached during the six month period. The intervention consisted of an educational video on health screening. The content of the video was taken from the recommended preventive care guidelines from CDC and USPSTF. The pre-and post-intervention knowledge of the participants was assessed through a semi-structured coded questionnaire by an interviewer who was trained in data collection. Data was analyzed using SPSS version 26. Pre and post intervention knowledge adequacy was determined using MacNemar’s Chi-square test. Results Total 300 participants voluntarily participated into the study. Median age of the participants was 28 (IQR = 23.25–36.75) years. Majority of participants were males (56%). Following the intervention, there was significant increase in the proportion of participants (51.3% versus 68%) who had understanding of health screening check-up ( p  < 0.001). Following the study intervention, there was significant increase in proportion of participants who had adequate knowledge related to diabetes ( p  = 0.045), hypertension ( p  < 0.001), cholesterol ( p  < 0.001), cervical cancer ( p  < 0.001), colon cancer ( p  < 0.001) and hepatitis B & C ( p  < 0.001). No significant improvement in breast cancer related knowledge was observed ( p  = 0.074). Highest post-intervention increase in knowledge from baseline was observed for hypertension (13.3% versus 63.3%) followed by colon cancer (24.3% versus 59.3%), cholesterol (67 versus 96.7%), hepatitis b & C (56.7% versus 77.3%), diabetes (29.7% versus 48%), cervical cancer (1.7% versus 19%), and breast cancer (7.7% versus 18.3%). Conclusion This study highlighted a pivotal role of an educational video intervention in clinic waiting area to improve awareness regarding health screening among patients and their families. Further interventional community based or multicenter studies are warranted to assess the long-term impact of these educational videos on knowledge and utilization of health screening among adult population.

Membrane Distillation (MD) is a membrane-based, temperature-driven water reclamation process. While research emphasis has been largely on membrane design, upscaling of MD has prompted advancements in energy-efficient module design and configurations. Apart from the four conventional configurations, researchers have come up with novel MD membrane module designs and configurations to improve thermal efficiency. While membrane design has been the focus of many studies, development of appropriate system configurations for optimal energy efficiency for each application has received considerable attention, and is a critical aspect in advancing MD configurations. This review assesses advancements in modified and novel MD configurations design with emphasis on the effects of upscaling and pilot scale studies. Improved MD configurations discussed in this review are the material gap MD, conductive gap MD, permeate gap MD, vacuum-enhanced AGMD/DCMD, submerged MD, flashed-feed MD, dead-end MD, and vacuum-enhanced multi-effect MD. All of these modified MD configurations are designed either to reduce the heat loss by mitigating the temperature polarization or to improve the mass transfer and permeate flux. Vacuum-enhanced MD processes and MD process with non-contact feed solution show promise at the lab-scale and must be further investigated. Hollow fiber membrane-based pilot scale modules have not yet been sufficiently explored. In addition, comparison of various configurations is prevented by a lack of standardized testing conditions. We also reflect on recent pilot scale studies, ongoing hurdles in commercialization, and niche applications of the MD process.

Background Primary soft tissue sarcomas contribute to only 2% of all malignancies arising from the male genitourinary tract. Leiomyosarcoma (LMS) is a malignant soft tissue neoplasm which originates from the mesenchyme and has a characteristic smooth muscle differentiation. Usually, it presents as a painless, firm, slow-growing unilateral scrotal mass. Investigations include imaging, tumor markers, and histopathology. Case presentation A 65-year-old gentleman known diabetic and beta-thalassemic trait was referred to the Urology OPD at Letterkenny University Hospital. His presenting complaint was a left groin lump that appeared 1 year ago and was growing larger in size gradually. According to the patient, his lump was slightly painful (localized) initially that later became painless. He did not report any testicular trauma/infection or UTI. There was no significant history of malignancies running through his family. Clinical examination revealed a soft and lax abdomen, normal testes. There was a non-tender 2cm x 2cm well-circumscribed, mobile, firm to cystic irreducible left inguinoscrotal mass and appeared to be attached to the spermatic cord. Cough impulse was indiscernible. Ultrasound left groin showed 1.8 cm transverse x 1.4 cm AP x 1.9 cm sagittal) well-circumscribed ovoid nodular subcutaneous lesion present in the upper left inguinal area just lateral to the left pubic tubercle that appeared solid with heterogeneous internal echotexture and no internal calcification. Some internal vascularity is demonstrated with color Doppler assessment. Conclusion Because of its rareness, LMS represents a management conundrum. There is no standard protocol for treatment. We present a case and discuss the available evidence from the literature to date to help identify LMS of the spermatic cord that is highly unusual.

This study aimed to study the coupling between the left ventricle and left atrium in pediatric patients with mitral valve prolapse (MVP) by utilizing strain parameters and the left atrioventricular coupling index (LACI). A retrospective analysis was conducted over six years to identify patients with MVP and moderate mitral regurgitation who had undergone cardiac MRI. The study included 20 patients and 20 healthy controls. Functional and strain assessments of the left ventricle (LV), right ventricle (RV), and left atrium (LA) were performed and compared to those of healthy controls. LACI was determined by calculating the ratio of the LA end-diastolic volume indexed to the left ventricular end-diastolic volume indexed, and it was correlated with conventional CMR and strain parameters. Native T1 mapping was used as a non-contrast CMR technique to assess diffuse myocardial fibrosis in all patients. LACI revealed a negative correlation with left ventricular end-diastolic volume indexed to body surface area (LVEDVI) and total left atrial ejection fraction (LAEF) ( r = -0.39, -0.65, P  < 0.05, respectively). In addition, LACI showed a correlation with strain parameters, specifically with LA longitudinal peak positive strain rate and left ventricular global circumferential strain (LV GCS) ( r  = 0.35, -0.49, P  < 0.05, respectively). The results from the multivariate regression analysis indicated that the left atrial longitudinal reservoir strain (ξs) was independently associated with left ventricular ejection fraction [β = 0.529; 95% confidence intervals (CI) = 0.192 to 0.866] and LV GRS [β = 0.229; 95% CI = 0.128 to 0.330]. There were statistically significant differences in LACI and LA ξs between patients who experienced clinical events such as arrhythmia and those who did not, with p-values of < 0.05. Strain parameters showed better results in evaluating LA and LV coupling in our patient group. Elevated native T1 values correlated with LACI, impaired LV, and LA strain parameters.

Melioidosis, caused by the bacterium Burkholderia pseudomallei, is an uncommon infection that is typically associated with exposure to soil and water in tropical and subtropical environments. It is rarely diagnosed in the continental United States. Patients with melioidosis in the United States commonly report travel to regions where melioidosis is endemic. We report a cluster of four non–travel-associated cases of melioidosis in Georgia, Kansas, Minnesota, and Texas. These cases were caused by the same strain of B. pseudomallei that was linked to an aromatherapy spray product imported from a melioidosis-endemic area. Four cases of non–travel-associated melioidosis (caused by Burkholderia pseudomallei ) that were identified across the United States were associated with the use of a contaminated aromatherapy room spray.