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Introduction: This study examines the news content produced by Turkish Political Islamist-oriented press’s thought through quantitative content analysis and critical discourse analysis. Social media journalism, recognized as an emerging value in journalism studies, is the primary focus of this research. Methodology: The study examining the discourse of news on social media posits that news content, in this context, is predominantly centered around ethnic sectarianism. The analysis focuses on Twitter/X posts related to Iran’s failed attack attempt on Israel on April 13, 2024. The study distinguishes two models of social media journalism: influencer journalism and the social media representations of traditional media outlets. Profiles such as “@themarginale” and “@turankislakci” exemplify influencer journalists, while the social media accounts of Yeni Akit and Sabah newspapers represent traditional media outlets. The study analyzed 8 news posts shared by journalists within the sample group on April 13-14, 2024. Results: The findings indicate that social media news content from Turkish Islamist-oriented media representatives internalizes ethnic sectarianism, reflecting ideological biases. This content often amplifies divisive narratives, prioritizing ethnic and religious identities over objective reporting. Discussion: The study highlights the Turkish Political Islamist-oriented press’s tendency to frame the Palestine issue through an ethnic sectarian lens, revealing the problematic nature of its ideological stance. These ideological patterns significantly influence readers’ perceptions of controversial issues, underscoring the need for critical analysis of such discourse to understand its broader societal impact. Conclusions: The influential power of social media news highlights the necessity of analyzing such content. Introducción: Este estudio analiza el contenido noticioso producido por la prensa turca de orientación islamista política a través de un análisis cuantitativo de contenido y un análisis crítico del discurso. El periodismo en redes sociales, reconocido como un valor emergente en los estudios de periodismo, es el enfoque principal de esta investigación. Metodología: El estudio examina el discurso de las noticias en redes sociales, planteando que el contenido noticioso, en este contexto, se centra predominantemente en el sectarismo étnico. El análisis se enfoca en publicaciones de Twitter/X relacionadas con el intento fallido de ataque de Irán a Israel el 13 de abril de 2024. Se distinguen dos modelos de periodismo en redes sociales: el periodismo de influencers y las representaciones en redes sociales de medios tradicionales. Perfiles como “themarginale” y “turankislakci” ejemplifican a los periodistas influencers, mientras que las cuentas de redes sociales de los periódicos Yeni Akit y Sabah representan a los medios tradicionales. Se analizaron ocho publicaciones de noticias compartidas por periodistas dentro del grupo de muestra entre el 13 y 14 de abril de 2024. Resultados: Los hallazgos indican que el contenido noticioso en redes sociales de los representantes de medios turcos de orientación islamista internaliza el sectarismo étnico, reflejando sesgos ideológicos. Este contenido a menudo amplifica narrativas divisivas, priorizando identidades étnicas y religiosas sobre un reporte objetivo. Discusión: El estudio destaca la tendencia de la prensa turca de orientación islamista política a enmarcar la cuestión palestina a través de una lente de sectarismo étnico, revelando la naturaleza problemática de su postura ideológica. Estos patrones ideológicos influyen significativamente en las percepciones de los lectores sobre temas controvertidos, subrayando la necesidad de un análisis crítico de dicho discurso para comprender su impacto social más amplio. Conclusiones: El poder influyente de las noticias en redes sociales resalta la necesidad de analizar dicho contenido.

Neuroinflammation in the pathogenesis of neurodegenerative diseases is still a subject of discussion, as it might be either the cause or the result of neurodegeneration. Misfolded or improperly aggregated α-synuclein in Parkinson’s Disease, can cause inflammatory responses, indicating a mechanistic relationship between α-synuclein pathology and neuroinflammation. The aim of this study was to investigate the role of DNA topoisomerase IIβ, the key player of DNA topology, in the neuroinflammation process in an age-dependent transgenic Parkinson’s Disease mouse model overexpressing the A53T mutant α-synuclein. In this study, transgenic and control mice were bred in three age groups as early (3 months), mid (8 months), and late (12 months) disease stages. Behavioral experiments were carried out to compare the age-related cognitive and motor coordination functions. Cytokine levels in the serum and protein expression levels in the dissected brain were analyzed by both western blot and immunofluorescence staining. A decline was observed in the cognitive and motor coordination functions depending on age. Disease-related markers at protein level appeared even in the early stage, and accordingly, a significant increase was observed in inflammatory markers and cytokine levels compared to control. DNA Topoisomerase IIβ and Nurr1 levels decreased in transgenic mice, especially more dramatically in the early stage. The combined effect of reduced Nurr1 and DNA Topoisomerase IIβ, along with increased inflammation, may provide a better understanding of the pathogenesis of Parkinson’s Disease at early-stage and requires for further investigation of the potential alterations in topo IIβ as an intervention strategy for this disease.

Öğretmen adaylarının eğitiminde eğitsel dijital oyunların kullanılması, teknolojik gelişmelerin eğitim-öğretim ortamında nasıl kullanılabileceğine ilişkin göstergeler sunması noktasında büyük bir öneme sahiptir. Bu çalışmanın amacı, sınıf öğretmeni adaylarına matematiksel kavramlardan Öklid Bölmesini (Kalanlı Bölme) tasarlanan eğitsel bir mobil oyunla tanıtmaktır. Araştırmacılar tarafından oluşturulan mobil oyunun tasarımında Didaktik Durumlar Teorisi'nin (DDT) temel bileşenlerinden biri olan adidaktik durumlardan yararlanılmıştır. Araştırmada nitel araştırma yöntemi kullanılmıştır. Tasarlanan oyun önce 3 sınıf öğretmeni adayına, sonra sınıf ortamında 12 (8 kız ve 4 erkek) sınıf öğretmeni adayına uygulanarak (73 dakika) pilot çalışması yapılmıştır. Araştırmanın katılımcılarını bir devlet üniversitesinde öğrenim gören sınıf öğretmeni adaylarından 14 kişi (6 kız ve 8 erkek) oluşturmaktadır. Asıl uygulama 67 dakika sürmüştür. Veriler, video kamera ve ses kayıt cihazı ile toplanmıştır. Verilerin analizi DDT'nin aşamaları doğrultusunda analiz edilmiştir. Analiz sonuçları, DDT çerçevesinde tasarlanan bir mobil oyun vasıtasıyla sınıf öğretmeni adaylarının matematiksel kavramlardan Öklid Bölmesini öğrenebileceği bir ortamın oluşturulabildiğini göstermiştir. Öğretmen adaylarının eğitiminde matematiksel kavramların tasarlanan eğitsel bir mobil oyunla öğretilme durumu, sınıf ortamında teknolojik araçların nasıl kullanılabileceğine yönelik eğitim alanında farklı bir bakış açısı katması noktasında önemli bir rol üstlenebileceği düşünülmektedir.

Background The purpose of this retrospective study was to determine the prognosis of non-serous epithelial ovarian cancer (EOC) patients with exclusively retroperitoneal lymph node (LN) metastases, and to compare the prognosis of these women to that of patients who had abdominal peritoneal involvement. Methods A multicenter, retrospective department database review was performed to identify patients with stage III non-serous EOC at 7 gynecologic oncology centers in Turkey. Demographic, clinicopathological and survival data were collected. The patients were divided into three groups based on the initial sites of disease: 1) the retroperitoneal (RP) group included patients who had positive pelvic and /or para-aortic LNs only. 2) The intraperitoneal (IP) group included patients with > 2 cm IP dissemination outside of the pelvis. These patients all had a negative LN status, 3) The IP / RP group included patients with > 2 cm IP dissemination outside of the pelvis as well as positive LN status. Survival data were compared with regard to the groups. Results We identified 179 women with stage III non-serous EOC who were treated at 7 participating centers during the study period. The median age of the patients was 53 years, and the median duration of follow-up was 39 months. There were 35 (19.6%) patients in the RP group, 72 (40.2%) in the IP group and 72 (40.2%) in the IP/RP group. The 5-year disease-free survival (DFS) rates for the RP, the IP, and IP/RP groups were 66.4%, 37.6%, and 25.5%, respectively ( p  = 0.002). The 5-year overall survival (OS) rate for the RP group was significantly longer when compared to those of the IP, and the IP/RP groups (74.4% vs. 54%, and 36%, respectively; p  = 0.011). However, we were not able to define “RP only disease” as an independent prognostic factor for increased DFS or OS. Conclusions Primary non-serous EOC patients with node-positive-only disease seem to have better survival when compared to those with extra-pelvic peritoneal involvement.

ObjectiveThe purpose of this retrospective study was to compare the prognoses of women with ovarian carcinosarcoma (OCS) who had optimal cytoreductive surgery followed by platinum plus taxane combination chemotherapy to those of women with ovarian high-grade serous carcinoma (HGSC) treated in the same manner.MethodsA multicenter, retrospective department database review was performed to identify patients with OCS at eight gynecologic oncology centers in Turkey. A total of 54 women with OCS who had undergone optimal cytoreductive surgery followed by platinum plus taxane combination chemotherapy between 1999 and 2017 were included in this case–control study. Each case was matched to two women with ovarian HGSC who had undergone optimal cytoreductive surgery followed by platinum plus taxane combination chemotherapy. The Kaplan–Meier method was used to generate survival data. Factors predictive of outcome were analysed using Cox proportional hazards models.ResultsMedian disease-free survival (DFS) was 29 months [95% confidence interval (CI) 0–59, standard error (SE) 15.35] versus 27 months (95% CI 22.6–31.3, SE 2.22; p = 0.765) and median overall survival (OS) was 62 versus 82 months (p = 0.53) for cases and controls, respectively. For the entire cohort, the presence of ascites [hazard ratio (HR) 2.32; 95% CI 1.02–5.25, p = 0.04] and platinum resistance [HR 5.05; 95% CI 2.32–11, p < 0.001] were found to be independent risk factors for decreased OS.ConclusionDFS and OS rates of patients with OCS and HGSC seem to be similar whenever optimal cytoreduction is achieved and followed by platinum plus taxane combination chemotherapy.

Background The purpose of this case-control study was to compare the prognoses of women with stage III mucinous ovarian carcinoma (MOC) who received maximal or optimal cytoreduction followed by paclitaxel plus carboplatin chemotherapy to those of women with stage III serous epithelial ovarian cancer (EOC) treated in the similar manner. Methods We performed a multicenter, retrospective review to identify patients with stage III MOC at seven gynecologic oncology departments in Turkey. Eighty-one women with MOC were included. Each case was matched to two women with stage III serous EOC in terms of age, tumor grade, substage of disease, and extent of residual disease. Survival estimates were measured using Kaplan-Meier plots. Variables predictive of outcome were analyzed using Cox regression models. Results With a median follow-up of 54 months, the median progression-free survival (PFS) for women with stage III MOC was 18.0 months (95% CI; 13.8–22.1, SE: 2.13) compared to 29.0 months (95% CI; 24.04–33.95, SE: 2.52) in the serous group ( p  = 0.19). The 5-year overall survival rate of the MOC group was significantly lower than that of the serous EOC group (44.9% vs. 66.3%, respectively; p  < 0.001). For the entire cohort, presence of multiple peritoneal implants (Hazard ratio [HR] 2.39; 95% confidence interval [CI], 1.38–4.14, p  = 0.002) and mucinous histology (HR 2.28; 95% CI, 1.53–3.40, p  < 0.001) were identified as independent predictors of decreased OS. Conclusion Patients with MOC seem to be 2.3 times more likely to die of their tumors when compared to women with serous EOC.