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Inappropriate use of antibiotics in clinical settings is thought to have led to the global emergence and spread of multidrug-resistant pathogens. The goal of this study was to investigate the prevalence of genes encoding aminoglycoside resistance and plasmid-mediated quinolone resistance among clinical isolates of Klebsiella pneumoniae. All K. pneumoniae isolates were phenotypically identified using API 20E and then confirmed genotypically through amplification of the specific K. pneumoniae phoE gene. All isolates were genotyped by the enterobacterial repetitive intergenic consensus polymerase chain reaction technique (ERIC-PCR). Antibiotic susceptibility testing was done by a modified Kirby-Bauer method and broth microdilution. All resistant or intermediate-resistant isolates to either gentamicin or amikacin were screened for 7 different genes encoding aminoglycoside-modifying enzymes (AMEs). In addition, all resistant or intermediate-resistant isolates to either ciprofloxacin or levofloxacin were screened for 5 genes encoding the quinolone resistance protein (Qnr), 1 gene encoding quinolone-modifying enzyme, and 3 genes encoding quinolone efflux pumps. Biotyping using API 20E revealed 13 different biotypes. Genotyping demonstrated that all isolates were related to 2 main phylogenetic groups. Susceptibility testing revealed that carbapenems and tigecycline were the most effective agents. Investigation of genes encoding AMEs revealed that acc(6′)-Ib was the most prevalent, followed by acc(3′)-II, aph(3′)-IV, and ant(3′′)-I. Examination of genes encoding Qnr proteins demonstrated that qnrB was the most prevalent, followed by qnrS, qnrD, and qnrC. It was found that 61%, 26%, and 12% of quinolone-resistant K. pneumoniae isolates harbored acc(6′)-Ib-cr, oqxAB, and qebA, respectively. The current study demonstrated a high prevalence of aminoglycoside and quinolone resistance genes among clinical isolates of K. pneumoniae.

The Arabic conjunction bal(usually translated as even or rather in English), like its equivalent conjunction in other languages, is a vital connector which has been of great interest to researchers in different languages. Arabic scholars have for many centuries always defined it as a disjunctive conjunction which can also mean giving up or quitting. This study is an analysis of “bal” which attempts to move it from the category of disjunction and quitting to the broader scope of Argumentation. The term Argumentation in this study is used in linguistic sense proposed by French linguists Jead – Claude Anscombre and Oswald Ducrot in their Theory of Argumentation in language(TAL) Within this theoretical framework, argumentation is defined sa the act of targeting specific objectives. The function of connectors, based on this definition, is to achieve these objectives through structuring language in ways which lead the addressee to conclusions undeclared by the speaker even though they are the outcome of the lattr’s words.

Studying the moisture sorption behavior of Barhi dates is key to enhancing their drying efficiency, packaging strategies, and storage conditions to ensure long-term stability and shelf-life. This research analyzed the sorption isotherms of vacuum-dried (VDBD) and freeze-dried Barhi dates (FDBD) via a dynamic vapor sorption apparatus across different temperatures and a wide range of water activity levels. Various mathematical models were evaluated to determine their accuracy in predicting sorption behavior, and the thermodynamic properties of sorption were examined in relation to the equilibrium moisture content (X e ). The results demonstrated that VDBD and FDBD followed Type III adsorption and Type V desorption isotherms. Adsorption increased with increasing water activity, whereas desorption displayed the opposite trend, with significant hysteresis between the two processes. The Peleg model provided a precise fit for both the adsorption and desorption isotherms across all the tested conditions. To maintain safe storage at the studied temperatures and 50% relative humidity, the recommended moisture content was 5% for VDBD and 9%. for FDBD. Additionally, the net isosteric heat of sorption (Q st ), differential entropy (ΔS), and Gibbs free energy (ΔG) exhibited inverse correlations with X e , increasing as the moisture content decreased during sorption. These thermodynamic parameters were effectively modeled as functions of X e , indicating that both adsorption and desorption were nonspontaneous processes. This study provides critical insights for food processors to refine drying protocols and establish optimal storage conditions for VDBD and FDBD, ultimately preserving quality and preventing microbial contamination.

Gut microbiota plays a pivotal role in various health challenges, particularly in mitigating diabetes-induced renal damage. Numerous studies have highlighted that modifying gut microbiota is a promising therapeutic strategy for preserving kidney function and mitigating diabetes-related complications. This study aimed to evaluate the protective effects of Lactobacillus acidophilus ATCC 4356 supplementations on kidney health in a rat model of diabetes-induced renal damage. Four groups were studied: control, probiotic supplementation, diabetic, and diabetic with probiotic supplementation. Diabetes was induced using a single streptozotocin (STZ) injection after a 12 h fast, and probiotic supplementation (1 × 10⁹ CFU/kg daily) was administered two weeks prior to diabetes induction and continued throughout the experimental period. Weekly assessments included fasting blood glucose, insulin, glycation markers, and kidney function tests. Glucose metabolism and insulin sensitivity were analyzed through oral glucose tolerance test (OGTT) and insulin sensitivity test (IST). The microbiome was analyzed using 16S rRNA gene sequencing to evaluate changes in diversity and composition. Probiotic supplementation significantly enhanced microbial diversity and composition. Alpha diversity indices such as Shannon and Chao1 demonstrated higher values in the probiotic-treated diabetic group compared to untreated diabetic rats. The Firmicutes/Bacteroidetes ratio, a key indicator of gut health, was also restored in the probiotic-treated diabetic group. Results: Probiotic supplementation significantly improved glycemic control, reduced fasting blood glucose levels, and enhanced insulin sensitivity in diabetic rats. Antioxidant enzyme levels, depleted in untreated diabetic rats, were restored, reflecting reduced oxidative stress. Histological analysis showed better kidney structure, reduced inflammation, and decreased fibrosis. Furthermore, the Comet assay results confirmed a reduction in DNA damage in probiotic-treated diabetic rats. Conclusion: Lactobacillus acidophilus ATCC 4356 supplementation demonstrated significant protective effects against diabetes-induced renal damage by restoring gut microbiota diversity, improving glycemic control, and reducing oxidative stress. These findings highlight the potential of targeting the gut microbiota and its systemic effects on kidney health as a therapeutic approach for managing diabetes-related complications. Further research is needed to optimize probiotic treatments and assess their long-term benefits in diabetes management and kidney health.

In recent decades, conflicts between hamadryas baboons (Papio hamadryas) and the rapidly growing human population in the mountainous areas of Western, Southwestern, and Southern Saudi Arabia have accelerated. This conflict, historically occurring mainly between farmers and baboons, has now moved to the urbanized areas in the baboon range and is mainly caused by the common use of spatial and other resources by baboons and humans. The goal of this study was to describe the spatial distribution of baboon groups and to estimate the population size of baboons in the Al-Baha region. The results indicate that baboons are present in all administrative areas of the Al-Baha region with a concentration along the mountain chain running from northwest to southeast and the western part of the region. As expected, rubbish dumps constitute baboon hotspots due to the large amounts of human-derived food. However, the baboons also travel into towns for foraging. The prevention of baboon accessibility to human-derived food would be an important step to reduce causes of conflicts between humans and baboons.

Human–wildlife conflicts arise from increasing human populations and the growing demand for land for agriculture and urban development. In Saudi Arabia, these dynamics have increased the impact of baboons on human communities, as expanding settlements encroach upon the natural habitats of baboons, while rising baboon populations increasingly invade urban areas in search of food, shelter, and water. We aimed to assess the effects of human–baboon coexistence on residents in the Al-Baha region, Saudi Arabia. From October 2021 to April 2022, we administered a 43-item semi-structured online questionnaire addressing emotional, social, environmental and financial impacts of nearby baboons. A total of 318 residents of the Al-Baha region completed the survey and shared their experiences regarding interactions with hamadryas baboons (Papio hamadryas) near human properties. In addition, three semi-structured life interviews with residents aged over 70 explored historical perceptions. Respondents attributed increased baboon presence to urban expansion, accessible waste, and intentional feeding and strongly supported government-led mitigation plans. Human–baboon interactions in Al Baha produce emotional stress, social disruption, and economic burdens for residents. Findings support integrated management combining public education, improved waste management, non-lethal deterrents, and carefully planned population control measures, developed with community consultation. Limitations of the study include convenience online sampling and reliance on self-reported impacts; future work should quantify baboon abundance and objectively measure economic losses.

Malaria parasitemia is the quantitative measurement of the parasites in the blood to grade the degree of infection. Light microscopy is the most well-known method used to examine the blood for parasitemia quantification. The visual quantification of malaria parasitemia is laborious, time-consuming and subjective. Although automating the process is a good solution, the available techniques are unable to evaluate the same cases such as anemia and hemoglobinopathies due to deviation from normal RBCs’ morphology. The main aim of this research is to examine the microscopic images of stained thin blood smears using a variety of computer vision techniques, grading malaria parasitemia on independent factors (RBC’s morphology). The proposed methodology is based on inductive approach, color segmentation of malaria parasites through adaptive algorithm of Gaussian mixture model (GMM). The quantification accuracy of RBCs is improved, splitting the occlusions of RBCs with distance transform and local maxima. Further, the classification of infected and non-infected RBCs has been made to properly grade parasitemia. The training and evaluation have been carried out on image dataset with respect to ground truth data, determining the degree of infection with the sensitivity of 98 % and specificity of 97 %. The accuracy and efficiency of the proposed scheme in the context of being automatic were proved experimentally, surpassing other state-of-the-art schemes. In addition, this research addressed the process with independent factors (RBCs’ morphology). Eventually, this can be considered as low-cost solutions for malaria parasitemia quantification in massive examinations.

Herein, we report the synthesis of activated biochar from green algae and the effect of its doping on the structural, photocatalytic, and energy storage properties of PEDOT-PSS. The morphology of pure and doped samples was investigated with Fourier Transform Infrared Spectroscopy (FTIR), Atomic Force Microscopy (AFM), Brunauer–Emmett–Teller (BET) analysis, and thermogravimetric analysis (TGA). AFM results for PEDOT-PSS@6wt.% of BC indicate that the calculated average peak height, particle size, and roughness were 283 nm, 136 nm, and 71 nm, respectively. Adding biochar to PEDOT-PSS significantly improved the thermal stability of PEDOT-PSS up to 550 °C. The novel photocatalyst PEDOT-PSS@6wt.% BC improved photocatalytic performance by approximately 17% in Methylene Blue (MB) dye removal. The electrochemical performance in terms of supercapacitors for the synthesized samples was investigated using cyclic voltammetry (CV), galvanostatic charge–discharge (GCD), specific capacitance, stability, and electrochemical impedance spectra (EIS). PEDOT-PSS@6wt.% of BC as a novel electrode material in supercapacitors exhibits an initial specific capacitance of 1300 Fg−1. Moreover, the PEDOT-PSS@6wt.% of BC electrode shows excellent stability up to 1000 cycles of operation. The EIS studies suggest the presence of charge transfer resistance. Considering the economical biosynthesis and multifunctional features, the PEDOT-PSS@6wt.% of BC could potentially be used as a photocatalyst to remove organic dyes and supercapacitors in energy storage applications.

Convection drying in combination with ultrasound pretreatment has emerged as a promising technology for seafood manufacturing. The primary objective of this research was to model the mass transfer process of Asian seabass (Lates calcarifer) fish skin without and with ultrasound pretreatment during convection drying at different temperatures (45, 55, and 65 °C). Additionally, the study aimed to examine the impact of ultrasound pretreatment and temperatures on the drying characteristics and specific energy consumption for drying of Asian seabass fish skin. Seven semi-theoretical models, namely Lewis, Page, modified Page, Vega-Lemus, Verma, Henderson and Pabis, and two-term models, were employed to characterize the moisture transfer process. The results of the study indicated a decrease in the moisture content as the drying time increased at different drying temperatures. Higher drying temperatures were associated with an increased drying rate. Among the mathematical models tested, the modified Page model provided a satisfactory description of the thin-layer drying characteristics of fish skin. Fick’s law of diffusion was utilized to determine the effective moisture diffusivities. Comparing the drying of fish skin without (SS) and with ultrasound pretreatment (US-SS), the drying of the latter generally showed higher Deff values. The temperature dependence of the effective diffusivity coefficient was well described by the Arrhenius-type model. An increase in the drying temperature resulted in an increment of the effective moisture diffusivity. In general, the skin pretreated using ultrasound had a reduced drying time, by up to 28%. Additionally, this approach contributed to an approximate 22% reduction in the specific energy consumption, concurrently enhancing the energy efficiency. The microstructure analysis showed that fresh and dried US-SS samples had a more open structure and higher porosity, in comparison to the corresponding SS samples. These findings contribute to the knowledge on the application of ultrasound as the pretreatment of fish skin before drying and provide valuable insights for the development of potential drying techniques in the seafood industry.

The aim of this review is to investigate the basic principles of red meat cooking technologies, including traditional and modern methods, and their effects on the physical, thermal, mechanical, sensory, and microbial characteristics of red meat. Cooking methods were categorized into two categories: traditional (cooking in the oven and frying) and modern (ohmic, sous vide, and microwave cooking). When red meat is subjected to high temperatures during food manufacturing, it undergoes changes in its engineering and quality attributes. The quality standards of meat products are associated with several attributes that are determined by food technologists and consumers based on their preferences. Cooking improves the palatability of meat in terms of tenderness, flavor, and juiciness, in addition to eliminating pathogenic microorganisms. The process of meat packaging is one of the important processes that extend the life span of meat and increase its shelf life due to non-exposure to oxygen during cooking and ease of handling without being exposed to microbial contamination. This review highlights the significance of meat cooking mathematical modeling in understanding heat and mass transfer phenomena, reducing costs, and maintaining meat quality. The critical overview considers various production aspects/quality and proposed methods, such as, but not limited to, hurdle technology, for the mass production of meat.