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This study aims at investigating the effect of using the discrepant events strategy on modifying the alternative misconceptions in chemistry of 10th grade students compared with the traditional method. The researcher used the semi-experimental method by applying the study to a sample of (74) 10th grade female students in the secondary school of girls in the district of Tulkarem, in the second semester of the academic year (2016/2017). To actualize the purpose of the study, the researcher used the alternative misconceptions test. The analysis of variance (ANCOVA) showed presence of a statistically significant difference between the means of grades of the students on the alternative misconceptions test was in favors of experimental group members. Based on the results, the study recommends that it is important to use this strategy in teaching chemistry because of its role in modifying the student's misconceptions.