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Breast cancer susceptibility gene II ( BRCA2 ) is central in homologous recombination (HR). In meiosis, BRCA2 binds to MEILB2 to localize to DNA double-strand breaks (DSBs). Here, we identify BRCA2 and MEILB2-associating protein 1 (BRME1), which functions as a stabilizer of MEILB2 by binding to an α-helical N-terminus of MEILB2 and preventing MEILB2 self-association. BRCA2 binds to the C-terminus of MEILB2, resulting in the formation of the BRCA2-MEILB2-BRME1 ternary complex. In Brme1 knockout ( Brme1 −/− ) mice, the BRCA2-MEILB2 complex is destabilized, leading to defects in DSB repair, homolog synapsis, and crossover formation. Persistent DSBs in Brme1 −/− reactivate the somatic-like DNA-damage response, which repairs DSBs but cannot complement the crossover formation defects. Further, MEILB2-BRME1 is activated in many human cancers, and somatically expressed MEILB2-BRME1 impairs mitotic HR. Thus, the meiotic BRCA2 complex is central in meiotic HR, and its misregulation is implicated in cancer development. In meiosis, BRCA2 associates to MEILB2 localising at DNA double-strand breaks (DSBs). Here, the authors identify BRCA2 and MEILB2- associating protein 1 termed BRME1 to work together in regulating meiotic recombination.

The cost of solar PV has been reduced to a level such that the levelized cost of solar electricity is either cheaper or competitive relative to the grid electricity. So, a low-cost integration of solar PV with grid can be a cost-effective solution for clean cooking. The usual technique of using grid-tied inverters contribute ~20% towards the energy cost. The proposed system incorporates a control circuit that connects grid electricity to the solar PV via a DC link and provides a DC output eliminating the requirement of grid-tied inverters. Most of the cooking utensils either have a resistive heating element or an electronic control circuit that is insensitive to input AC or DC and no modification is needed for the cooking utensils while using with DC voltage. In the proposed system, preference for power delivery is always given to the solar PV and the grid effectively operates as the backup for the system when solar PV output fluctuates due to varying weather and climatic conditions. As the absence of a grid-tied inverter in the system restricts the excess solar energy to be transferred to the grid, some kind of energy storage device is essential to run the system efficiently. A novel idea of storing solar PV energy in the form of hot water has been presented in this paper, with a cost-effective clean cooking concept. A simple and low-cost heat preservation technique has been suggested that requires a minimal change in habit for the users. Experimental results with multiple cooking utensils and foods have been presented and energy cost for cooking has been found to be as low as 4.75 USD/month, which is significantly lower (32%) than that of the grid-connected regular cooking system.

Drought has exacerbated morbidity and mortality worldwide. Here, a time series study was conducted in northern Bangladesh to evaluate the impact of drought on selected causes of mortality during 2007–2017. Rainfall and temperature data from six meteorological stations were used to analyze drought and non-drought periods and to categorize mild, moderate, severe, and extreme drought based on the 3-month and 12-month Standardized Precipitation Index (SPI) and Standardized Precipitation Evaporation Index (SPEI). A generalized linear model with Poisson regression with log link, a negative binomial with log link, and a zero-inflated Poisson model were used to determine associations between drought severity and mortality. The SPI and SPEI produced slightly different analysis results. Compared with the SPEI, the SPI showed a stronger and more sensitive correlation with mortality. The relative risk for respiratory disease mortality was high, and Saidpur was the most vulnerable area. Health care expenditure was negatively associated with mortality. High temperatures during the drought period were associated with suicide-related mortality in Rajshahi. The impact of drought on mortality differed with small changes in climate. The findings of this study improve our understanding of the differences between the two most used drought indicators and the impact of drought on mortality.

Green energy from Solar PV is getting increased attention in the industries due to the falling price of solar panels in the world market. A grid-tied inverter is one of the major components in such a system, where the DC energy from PV is converted to AC and synchronized with the grid to obtain power sharing between the PV and the grid for the industrial drives. In this paper, a DC link has been proposed instead of an AC link for interconnection between the solar PV system and the grid to run those industrial drives. In most modern industrial applications, induction motors are driven by VVVF (Variable Voltage and Variable Frequency) inverters to achieve efficient speed control. The inverters commonly have a rectifier section at the front end that rectifies the input AC to DC and the DC is then used in PWM mode to generate the required voltage and frequency for the induction motor operating under variable speed and load conditions. Such an inverter can use both AC or DC as the input so long the supply voltage has the right value for the inverter to operate. In our proposition, we eliminate the grid-tied inverter and use a DC link, created from the rectified AC and the regular Solar PV, to obtain the power-sharing between the PV output and the grid. Using the DC link output directly to energize the VVVF inverter has an impact on the performance of the inverter. In the proposed system, the solar PV array is designed in such a way that the grid remains as the supplementary power source only to supplement any shortfall in the PV output due to variable sunshine conditions. The control circuit used in this novel technique is inexpensive, efficient, and simple in design when compared to the grid-tied inverters. The proposed system has been implemented at Niagara Textiles in Gazipur, Bangladesh. The experimental/practical results are presented to validate the basic concept. Around a 20% reduction in the cost of energy has been reported in this paper, with a more than 90% efficient system. This will definitely make solar PV energy more competitive with regular energy and attractive to industries for its simplicity.

Purpose - Few research studies have been done to investigate the issue of new service development (NSD) in an emerging market. To address this gap in the literature the aim of this paper is to document a study of the NSD process and the strategy of business-to-business financial service firms in India.Design methodology approach - The author conducted surveys of 148 multinational service firms operating in India and 126 local and indigenous Indian service firms belonging to the financial services industry.Findings - The findings suggest that significant differences exist between multinational service firms operating in India and local indigenous Indian firms. That is, service firms belonging to these two varied groups use different strategies to compete in the industry and emphasize different sets of development stages in service innovation.Research limitations implications - The analysis has been restricted to one emerging market, i.e. India. This suggests the need for further studies of NSD in other emerging markets of the world.Practical implications - The findings of this research validate the initial contention that NSD practices vary from company to company, and thus there cannot be a \"one size fits all\" approach to service innovation. The insights from this study can help service managers to better understand and manage their NSD programs in an emerging market such as India.Originality value - To the best of the author's knowledge, this research represents the first attempt to investigate empirically the NSD practices of financial service firms in India.

Purpose - Few research studies have been conducted to investigate the issue of new service development (NSD) across nations and geographical regions. To address this critique of the literature, the purpose of this paper is to conduct a comparative study of NSD process and strategy in a developed country, Australia and a developing country, India.Design methodology approach - The paper conducted surveys of 102 Australian firms and 97 Indian firms operating in the business-to-business financial services industry.Findings - The findings suggest that significant differences exist between the Australian and Indian firms. Service firms in both countries use different strategies to compete in the industry and emphasize different sets of development stages in developing new services.Research limitations implications - The analysis has been restricted to two countries: India and Australia. This suggests the need for further comparative studies of NSD in other cultures countries.Practical implications - The findings of this research validate the initial contention that NSD varies from country to country and thus there cannot be a \"one-size-fits-all\" approach to NSD. The insights from this study can help service managers from India, Australia and other countries to better understand and manage their NSD programs in a cross-national context.Originality value - To the best of the author's knowledge, this research represents the first attempt to empirically test the similarities and differences in NSD practices of Australian and Indian firms.

Protection and control automation messages transfer between devices and the control center (CC) over IEC 61850 standard protocols in active distribution network (ADN) using Ethernet. Wireless communication network provides real-time monitoring and control of ADN. The proposed novel approach framework presentsline to ground (LG) faults protection and control method utilizing IEC 61850 standards at bay level between intelligent protection devices for fast and reliable protection. Moreover, this bay level peer to peer communication utilizes IEEE 802.11 wireless local area network (WLAN)to reduce the fault protection time and other messages transferring time instead of Ethernet communication by GOOSE multicast communication services. End to end time delay and throughput of data transmission between the coordination nodes are illustrated using NS2 simulation.

This paper focuses on analyzing wind characteristics at Maulana Azad National Institute of Technology. Wind characteristics are site dependents, so it is reasonable that different wind regimes may have different wind speed distributions. Distributions appeared in the literature are revisited and a comparison between these distributions is carried out. Modified maximum likelihood method in Weibull distribution has shown better results over other. Justus and Mikhail method is used for vertical extrapolation of wind power density for higher heights. As a conclusion, the highest wind energy potential value was found in the month of June while the lowest value was encountered in November.

Background: Laminoplasty is a method of posterior cervical decompression which indirectly decompresses the spinal column. Unfortunately, many patients undergoing laminoplasty develops postoperative loss of cervical lordosis (LCL) or kyphotic alignment of cervical spine even though they have sufficient preoperative lordosis which results in poor surgical outcome. Objective: We would like to highlight the relationship between various radiological parameters of cervical alignment and postoperative LCL in patients undergoing laminoplasty. Methods: We performed extensive literature search using PubMed, Google Scholar, and Web of Science for relevant articles that report factors affecting cervical alignment following laminoplasty. Results: On reviewing the literature, patients with high T1 slope have more lordotic alignment of cervical spine preoperatively. They also have more chances of LCL following laminoplasty. C2-C7 sagittal vertical axis (SVA) has no role in predicting LCL following laminoplasty though patients with low T1 slope (≤20°) and high C2-C7 SVA (>22 mm) had correction of kyphotic deformity following laminoplasty. C2-C7 lordosis, Neck Tilt, cervical range of motion, and thoracic kyphosis has no predictive value for LCL. Lower value of T1 slope (T1S-CL) and CL/T1S has more incidence of developing LCL following laminoplasty. The role of C2-C3 disc angle has not yet been evaluated in patients undergoing laminoplasty. Dynamic extension reserve determines the contraction reserve of SPMLC and lower dynamic extension reserve is associated with higher chances of LCL following laminoplasty. Conclusions: Cervical lordotic alignment is important in maintaining cervical sagittal balance which ultimately is responsible for global spinal sagittal balance and horizontal gaze. Among various radiological parameters, T1 Slope has been reported to be the most important factor affecting cervical alignment following laminoplasty.