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Background. The presence of extensive workload and pressure associated with COVID19 has resulted in a lot of mental and physical trauma in primary health care physicians (PHCC) across the world. Aim of the study. The present study is aimed at understanding the level of dissatisfaction in PHCC physicians in the Asser region of Saudi Arabia. The various risk factors associated with dissatisfaction also have been analyzed in this study. Method. An analytical cross-sectional study was performed on various PHCCs who were working in the Ministry of Health in the Asser region. Results. The overall analysis showed that around 73% of the physicians who responded showed dissatisfaction. The major factors that were found to affect satisfaction based on the variables analyzed include physicians who are males, Saudi Nationals, training residents, and those who received recognition. These four variables had a p value of less than 0.0001 making it statistically significant. Conclusion. The study observed that there is dissatisfaction amongst PHCC physicians towards the management of pandemics. The factors identified should help officials in order to address these issues

Education and learning have been significantly impacted by ICT. The purpose of this project is to create a new model and conduct confirmatory factor analysis in order to better understand how students utilize ICT in the classroom. An additional aim is to study, based on students’ attitudes and aspirations to utilize ICT for digital learning, their fundamental computer abilities, media-related skills, WBS, and adoption of digital learning technologies, by surveying students at Bisha University and King Faisal University. Structural equations modeling (SEM)-AMOS was used to survey 711 university students, and this study used an improved version of the Technology Acceptance Paradigm (TAM) approach as its research paradigm, as well as quantitative data collection and analytic methodologies. Students’ comments were divided into seven categories and analyzed to identify their attitudes toward and intentions for using ICT in learning environments. BCS, media-related abilities, and WBS all had a substantial influence on perceived usefulness and perceived ease of use, according to the research. This model, which was based on research, was successful in describing students’ attitudes and intentions about using ICT for digital learning.

Background and Objectives: This study introduces an innovative approach to accelerating wound healing by leveraging the bactericidal properties of mycosynthesized copper oxide nanoparticles (CuO-NPs) and their combination with curcumin against Pseudomonas aeruginosa. The study aims to evaluate their antimicrobial efficacy, impact on quorum sensing-associated virulence factors, and potential therapeutic applications in wound healing. Materials and Methods: The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of CuO-NPs were determined to be 25 μg/mL and 50 μg/mL, respectively. At sub-inhibitory concentrations (0.5 MIC, 0.25 MIC, and 0.125 MIC), their effects on P. aeruginosa growth and quorum sensing-associated virulence factors were assessed. Antioxidant activity and cytotoxicity were also evaluated. Additionally, the combination of CuO-NPs and curcumin (CUR) was tested for its enhanced wound-healing efficacy. Results: While CuO-NPs did not inhibit P. aeruginosa growth at sub-inhibitory concentrations, they significantly reduced quorum sensing-associated virulence factors in a dose-dependent manner: LasB elastase (81.8%, 60.6%, and 53.03%), LasA protease (70%, 68.5%, and 57.1%), and pyocyanin (85.7%, 71.4%, and 55.9%). CuO-NPs exhibited strong antioxidant activity by scavenging free radicals. The combination of CuO-NPs and CUR demonstrated the highest wound-healing efficacy, outperforming the negative control and Mebo ointment by 193.9% and 61.6%, respectively. Additionally, CuO-NPs exhibited selective cytotoxicity against HepG2 cancer cells while displaying minimal toxicity toward normal human skin cells. Conclusions: CuO-NPs, particularly in combination with CUR, show promising potential as a therapeutic agent for wound healing by inhibiting quorum sensing-associated virulence factors, exhibiting strong antioxidant activity, and demonstrating selective cytotoxicity. These findings highlight their potential biomedical applications.

Background: The likelihood of survival of an out-of-hospital cardiac arrest quadruples with the rapid application of basic life support (BLS). The public's ability to perform cardiopulmonary resuscitation (CPR) and use automated external defibrillators (AEDs) is extremely important. This study aimed to assess the public knowledge, attitudes, and practices (KAP) of utilizing AEDs and to understand barriers to AED application. Methods: We conducted a cross-sectional study from March 1-30, 2022. An electronic questionnaire was constructed and validated to measure the KAP for public AED utilization and its barriers. Results: Of the 406 participants, 244 (60.10%) were males. Male respondents had 17% less knowledge and poorer attitude towards using an AED as compared to female respondents. Knowledge and attitudes on using AEDs were low (70.7%) among Saudi nationals compared to those of foreign nationals. Those who were BLS/CPR trained had a 2.5 times greater understanding and willingness to use AEDs in public than those who were not. Barriers to AEDs in CPR/BLS-trained participants were: (1) accidentally hurting the victim (14.3%), (2) duty as a bystander to just call the ambulance and wait for help (12.1%), (3) never taught what to do (n = 41, 18.4%), (4) did not want to be scolded if performed wrong (3.1%), and (5) never witnessed such a situation (51.6%). Conclusion: There is a strong association between knowledge of and willingness to use AEDs in emergency situations among the public. Msconceptions about AEDs hinder their use. This calls for urgent training programs through accessible technology to reach the public. Keywords: automated external defibrillator, AED, public, cardiac arrest

Unmet need for contraception remains a persistent global reproductive health challenge. In Saudi Arabia, national estimates indicate moderate contraceptive uptake; however, region-specific data on awareness, accessibility, and utilization of family planning (FP) services remain limited, particularly in semi-rural settings such as Al-Baha. To evaluate awareness, access, and utilization of family planning and reproductive health services and to identify perceived barriers and sociodemographic determinants among adult women in Al-Baha, Saudi Arabia. A population-based cross-sectional study was conducted using a 23-item online questionnaire administered to female residents aged ≥18 years between December 2024 and February 2025 through convenience sampling. Descriptive statistics summarized participant characteristics and FP-related variables. Associations between categorical variables were assessed using chi-square ( ²) tests. Univariable and multivariable logistic regression analyses were performed to estimate crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs). Statistical significance was set at a two-sided  < 0.05. Ethical approval was obtained from the Deanship of Scientific Research, Al-Baha University (Approval No. 46110701-20241117), and electronic informed consent was secured prior to participation. A total of 892 women participated (mean age 38 ± 10.5 years). Awareness of FP initiatives was reported by 24%, and 18% had previously received FP consultation/services. Although 94% reported geographic access to a healthcare facility within 30 min, routine reproductive health service utilization remained limited, with 53% reporting infrequent visits. Current contraceptive use was reported by 42%, predominantly oral contraceptive pills (15%) and intrauterine methods (9%). Overall, 32% reported at least one barrier to contraception access, with \"other barriers\" (14%) and limited availability (11%) cited most frequently. Several outcomes demonstrated significant sociodemographic variation (  < 0.05). In multivariable analysis, age >30 years independently predicted current contraceptive use (aOR 3.97; 95% CI 2.64-5.98;  < 0.001). Despite reported geographic accessibility, awareness and counselling uptake remain suboptimal in Al-Baha. Targeted, culturally responsive primary care-based interventions and strengthened service availability are warranted to improve informed reproductive health decision-making.

We conducted a meta‐analysis to compare the effectiveness of negative pressure wound drainage to that of spontaneous wound drainage after thyroid tumour surgery. A thorough analysis of the literature up to July 2022 revealed that, of the 1234 patients who used surgery for thyroid tumours, 615 used negative pressure wound drainage and 619 used natural wound drainage. To measure the influence of negative pressure wound drainage in comparison to natural wound drainage following thyroid tumour surgery, mean difference (MD) and odds ratio (OR) with 95% confidence intervals (CIs) were measured using the contentious and dichotomous approaches with a random or fixed‐effect model. Subjects who used negative pressure wound drainage had significantly higher averages for drained material (OR, 12.52; 95% CI, 6.78‐18.26, P = 0.001), shorter drain placement times (MD, −1.06; 95% CI, 1.57 to −0.55, P = .001), lower rates of infection at the surgical site (OR, 0.17; 95% CI, 0.05‐0.60, P = .006), higher rates of wound healing (OR, 5.91; 95% CI, 1.56‐22.34, P = .009), and lower rate of wound seroma (OR, 0.21; 95% CI, 0.10‐0.42, P < .001) in subjects after thyroid tumour surgery in comparison to subjects who used natural wound drainage after thyroid tumour surgery. Those who used negative pressure wound drainage had significantly higher averages of drained material, shorter drain placement times, lower rates of wound infection at the surgical site, higher rates of wound healing, and lower rates of wound seroma. Care must be used when analysing the results because of the small sample size of 7 of the 13 studies included in the meta‐analysis and the lack of studies in several comparisons.

Objectives: To describe the frequency of cytotoxin-associated gene A A CagA) and vacuolating cytotoxin A (VacA) virulence genes and clarithromycin resistance-associated mutations among Helicobacter pylori (H. pylori) clinical isolates from Eastern Saudi Arabia. Methods: A cross-sectional study was carried out between July 2020 and June 2021 in a tertiary hospital in AL-Khobar, Saudi Arabia. A total of 34 H. pylori isolates were obtained from gastric biopsies of patients with dyspepsia. The existence of the virulence genes was studied by polymerase chain reaction and the gene fragment of the 23s ribosomal subunit (23s rRNA) gene was sequenced. Results: All isolates harbored the CagA gene. Approximately 97.1%(33/34) isolates were positive using the VacA M primer and 91.2%(31/34) isolates were positive using the VacA S primer. The most frequent allelic combination was S2/M2/cag (60%), followed by S1/M2/cag (26.7%), S1/M1/cag (10%), and S2/M1/cag(3.3%(. Approximately 6.5% isolates harbored the A2142G mutation and 29% isolates harbored the A2143G mutation. One isolate contained the mutation T2182C. The phylogenetic analysis showed that 58% isolates clustered with the regional and global isolates while the remaining 42% isolates seemed to be specifically circulating in Saudi Arabia. Most of the patients (73.5%) had already underwent a previous H. pylori eradication therapy. Conclusion: We showed that there is a regional variation in the frequency of the virulence genes among H. pylori isolates. Additionally, we showed the frequency of 23s rRNA mutations related to clarithromycin resistance in Saudi Arabia. Keywords: H. Pylori, clarithromycin, resistance, Saudi Arabia, 23s rRNA [phrase omitted]

The impact of different sociodemographic and clinical characteristics on the COVID-19-related morbidity and mortality rates have been studied extensively around the world; however, there is a dearth of data on the impact of different clinical and sociodemographic variables on the COVID-19-related outcomes in Saudi Arabia. This study aimed to identify those at high risk of worse clinical outcomes, such as hospitalization and longer length of stay (LOS) among young and middle-aged adults (18 to 55 years). In this questionnaire-based cross-sectional study, 706 patients with real-time polymerase chain reaction (RT-PCR) confirmed COVID-19 infection were interviewed. Patients’ demographic characteristics, dietary habits, medical history, and lifestyle choices were collected through phone interviews. Patients with chronic health conditions, such as diabetes and hypertension, reported a higher rate of hospitalization, ICU admission, oxygen-support needs, and a longer period of recovery and LOS. Multiple logistic regression showed that diabetes, hypertension, and pulmonary disease (e.g., asthma and chronic obstructive pulmonary disease (COPD)) were associated with a higher risk of hospitalization and longer LOS. Multiple logistic regression showed that symptoms of breathlessness, loss of smell and/or taste, diarrhea, and cough were associated with a longer recovery period. Similarly, breathlessness, vomiting, and diarrhea were associated with higher rates of hospitalization. The findings of this study confirm the similarity of the factors associated with worse clinical outcomes across the world. Future studies should use more robust designs to investigate the impact of different therapies on the COVID-19-related morbidity and mortality in Saudi Arabia.

Background Oncoplastic Breast surgeries (OBS) in breast cancer have evolved to preserve the cancerous breast rather than its amputation to improve postoperative cosmetic results. The lack of evidence to support the oncological safety and benefits of OBS is questionable. In this study, we evaluate various aspects of oncoplastic surgeries with a focused monitoring of aesthetic results and oncological safety. Methods This was a multi-center observational study focused on the statistics of data collected from cases who underwent oncoplastic surgeries from the cohort of breast cancer candidates at Mansoura University Hospitals/Egypt and King Faisal Medical Complex/KSA from January 2015 to June 2018. All data were analyzed carefully using SPSS v-26. Results Eighty cases who underwent different oncoplastic surgeries were included and reviewed for the aesthetic outcome and oncological safety. The recurrence rate was found to be 2.5%. The breast impact treatment scale assessment method was used to analyze the aesthetic outcomes, and average scores were accepted in 90% of patients. Conclusions The oncoplastic breast surgeries are feasible and they had a high rate of oncological safety with the maintenance of good aesthetic outcomes and patient satisfaction.

The world is still in need of an effective therapy to treat coronavirus disease-19 (COVID-19). This cross-sectional study was conducted on COVID-19 survivors in Saudi Arabia to investigate the influence of a healthy diet on the recovery time from COVID-19. A questionnaire was developed to assess participants’ dietary habits, based on the 2015 Dutch food-based dietary guidelines. A total of 738 COVID-19 survivors participated in the study, of whom 237 (32.1%) were hospitalized for COVID-19 treatment while 501 (76.9%) were not hospitalized, and 320 (43.4%) were females and 418 (56.6%) were males. Overall, no significant difference was noted in healthy diet score between males and females; however, this score was significantly lower for Saudis compared to non-Saudis. Among the non-hospitalized patients, eating a more healthy diet was associated with a shorter duration of recovery (p < 0.05) and was significantly affected by gender (15.8 ± 9.3 male vs. 12.1 ± 8.9 female; p < 0.001) and marital status (12.1 ± 8.4 singles vs. 13.7 ± 9.3 married vs. 16.1 ± 11.8 divorced; p < 0.05). In contrast, no significant correlation was found with age or BMI. In this study, a more healthy diet was associated with a shorter duration of recovery from COVID-19. However, further studies are needed to thoroughly investigate the relationship between diet and recovery time from COVID-19.