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The event industry is currently considered one of the key marketing strategies for tourist destinations, drawing tourists and fans alike. This study explores factors influencing attendance at festivals and cultural events in Katara Cultural Village, focusing on event reputation, electronic word of mouth (eWOM), enjoyment, socializing and cultural exploration. Few studies have examined reputation as a motivation, particularly in the event context. Researchers developed a theoretical model to understand these effects on behavioral intentions. Data was collected via an online survey distributed to Katara events and festivals Facebook followers and analyzed using partial least squares (PLS) technique. Findings reveal that event innovation reputation, event performance reputation, enjoyment, eWOM and cultural exploration positively impact intentions to attend Katara Cultural Village events. This research contributes to event literature by highlighting reputation as a significant motivator. Implications and study limitations were discussed.

Purpose The purpose of the study is to investigate the relationship between consumers’ attitudes toward hotel Twitter accounts and attitudes toward hotel brands, booking intentions and electronic word-of-mouth. The study focuses on Saudi Arabia owing to the widespread use of Twitter in that market. Design/methodology/approach Modifying a previously developed theoretical model on marketing effectiveness of social media, this study empirically tests consumers’ attitudes toward hotel Twitter accounts. Data have been collected via a structured online survey. A confirmatory factor analysis and a structural equation model fit have been used to test the model. Findings When consumers have positive attitudes toward hotel tweets, they have positive attitudes toward the hotel’s Twitter account, which, in turn, improves their attitudes toward the hotel’s brand and results in intent to book and spread electronic word of mouth. Originality/value The study contributes to the body of knowledge about social media marketing effectiveness in the hospitality industry. 论酒店Twitter营销的有效性：沙特阿拉伯案例分析 摘要 研究目的 本研究旨在于探索酒店消费者对于酒店Twitter营销的态度以及酒店Twitter营销对打造酒店品牌、消费者预订酒店行为、和电子口碑营销的影响。由于Twitter在沙特阿拉伯地区的广泛流行，本研究将沙特阿拉伯为案例进行调研。 研究设计/方法/途径 本研究在前人建立的社交媒体营销有效性模型的基础上，进行改进创新，并且实地调研了消费者对于酒店Twitter营销账户的态度。本研究采用网上问卷采样的方式，样本经过验证性因子分析法和结构方程模型的分析，来进行模型的测试。 研究结果 本研究表明，当消费者对于酒店Tweets持有积极态度的时候，他们对于酒店Twitter账户也同样保持积极态度，同时这种积极态度也会增进他们对于酒店品牌的认知，消费者更加愿意预订酒店房间，以及为酒店电子口碑营销。 研究原创性/价值 本研究结果对于酒店行业中社交媒体的营销有效性的探索有着积极贡献。

The medicinal application of pomegranate peel extract enriched with polyphenols (PPE) as a therapeutic strategy for managing inflammatory bowel diseases (IBD) is still limited. Integrating pomegranate peel extract (PPE) into an effective nanocarrier system could enhance its mechanistic actions, potentially aiding in the remission of colitis. Therefore, this approach aimed to enhance PPE’s stability and bioavailability and investigate mitigating impact of pomegranate peel extract-loaded nanoparticles (PPE-NPs) in a colitis model. Colonic injury was induced by 5% dextran sulfate sodium (DSS) and efficacy of disease progression after oral administration of PPE-NPs for 14 days was assessed by evaluating clinical signs severity, antioxidant and inflammatory markers, expressions of endoplasmic reticulum associated genes and histopathological and immunostaining analysis in colonic tissues. Clinical signs and disease activity index were effectively reduced, and the levels of fecal calprotectin were decreased in groups treated with PPE-NPs compared to DSS group. The colitic group showed a significant increase (P < 0.05) in C-reactive protein (CRP) and myeloperoxidase (MPO) and nitric oxide (NO) (35.60, 163.30 and 280 nmol/g tissue respectively) and higher expression (P < 0.05) IL-17 , TNF-α , and IL-1β (increased up to 2.99, 4.36 and 4.90 respectively unlike PPE-NPsIII that recorded reduced levels of CRP, MPO and NO (8,96, 78.30 and 123 nmol/g tissue respectively) and much lower (P < 0.05) levels of IL-17, TNF-α, and IL-1β expression (decreased to 1.23, 1.69 and 1.64, respectively). The most improvement of colon damage PPE-NPsIII group was also associated with the reduction MDA level (P < 0.05) (decreased to 21.60 vs 90.65 in DSS non treated group). The highest glutathione peroxidase, superoxide dismutase and catalase activities were noted in PPE-NPsIII received group (42.60, 50.30 and 62.70 U/mg). Notably, prominent free radical scavenging activities were noticed in group received 150 mg/kg of PPE-NPs as supported by higher scavenging of 1,1-diphenyl-2-picrylhydrazyl (9.85 mg/g) and 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid tested radicals (19.98 mg/g). Balancing between endoplasmic reticulum stressors (ERS), inflammation and autophagy was prominently noted in group treated with 150 mg/kg of PPE-NPs. These findings were supported by subsiding the excessive expression of ERS related genes ( CHOP , JUNK , ATF6 , BIP , and Elf -2) and immunostaining expression regulation of key markers regulating autophagy (Beclin-2) in this group. The histopathological changes in the colon were less severe in the PPE-NPs received groups (especially at the level of 150 mg/kg) compared to DSS group. Collectively, these findings suggest that the nanoencapsulation of PPE enhances its effectiveness in promoting recovery of colonic tissue damage and achieving remission of colitis.

Cancer ranks among the primary contributors to global mortality. In 2022, the global incidence of new cancer cases reached about 20 million, while the number of cancer-related fatalities reached 9.7 million. In Saudi Arabia, there were 13,399 deaths caused by cancer and 28,113 newly diagnosed cases of cancer. Drug repurposing is a drug discovery strategy that has gained special attention and implementation to enhance the process of drug development due to its time- and money-saving effect. It involves repositioning existing medications to new clinical applications. Cancer treatment is a therapeutic area where drug repurposing has shown the most prominent impact. This review presents a compilation of medications that have been repurposed for the treatment of various types of cancers. It describes the initial therapeutic and pharmacological classes of the repurposed drugs and their new applications and mechanisms of action in cancer treatment. The review reports on drugs from various pharmacological classes that have been successfully repurposed for cancer treatment, including approved ones and those in clinical trials and preclinical development. It stratifies drugs based on their anticancer repurpose as multi-type, type-specific, and mechanism-directed, and according to their pharmacological classes. The review also reflects on the future potential that drug repurposing has in the clinical development of novel anticancer therapies.

The emergence of multidrug-resistant Staphylococcus aureus underscores the urgent need for novel therapeutic agents targeting essential bacterial pathways. The lipoteichoic acid synthase (LtaS) is crucial for the synthesis of lipoteichoic acid in the cell wall of Gram-positive bacteria and represents a promising and vulnerable target for antimicrobial drug development. This study employed a comprehensive computational pipeline to identify potent inhibitors of the LtaS enzyme. A library of natural compounds was retrieved from the COCONUT database and screened against the crystal structure of the extracellular domain of LtaS (eLtaS) (PDB ID: 2W5R, obtained from the Protein Data Bank) through a multi-stage molecular docking strategy. This process started with High-Throughput Virtual Screening (HTVS), followed by Standard Precision (SP) docking, and culminated in Extra Precision (XP) docking to refine the selection of hits. The top-ranking compounds from XP docking were subsequently subjected to MM-GBSA binding free energy calculations for further filtration. The stability and dynamic behavior of the resulting candidate complexes were then evaluated using 100 ns molecular dynamics (MD) simulations, which confirmed the structural integrity and binding stability of the ligands. Density Functional Theory calculations revealed that screened ligands exhibit improved electronic stabilization and charge-transfer characteristics compared to a reference compound, suggesting enhanced reactivity and stability relevant for hit identification. Finally, ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profiling was conducted to assess the drug-likeness and pharmacokinetic safety of the lead compounds. These findings support them as promising orally active leads for further optimization. Our integrated approach shortlisted eight initial hits (A–H) that showed interesting scaffold diversity and finally identified two compounds, herein referred to as Compound A and Compound B, which demonstrated stable binding, favorable free energy, and an acceptable Absorption, Distribution, Metabolism, and Excretion, and Toxicity (ADMET) profile. These candidates emerge as promising starting points for developing novel anti-staphylococcal agents targeting the LtaS enzyme that cand be further proved by experimental validation.

Background Gynecological cancers (GCs) affect the reproductive system of females, and are of multiple types depending on the affected organ most common of which are cervical, endometrial, ovarian cancers. Among different risk factors for GCs, ABO blood group system is considered as one of the pivotal contributing factors for increased susceptibility of GCs. The aim of our study was to report on the demographics of GC patients and to investigate the relationship between the ABO blood group system and the risk of acquiring GC in our population. Methods The current retrospective cross-sectional study was carried out between the years of 2016 and 2023. The sample included all the patients having age > 18 with a record of blood group and confirmed histological or cytological diagnosis as per International Federation of Gynecology and Obstetrics (FIGO) guidelines. A comprehensive review of the charts was conducted to gather data including demographics, tumor characteristics, comorbidities, adverse effects, and treatment methods. Results A total of 543 female patients were included in the study. The mean age of patients was 61.6. The three most common BG in our GC cases were as O + (43.8%), followed by A + (26%), and B + (15.5%). Among comorbidities, hypertension (HTN), diabetes mellitus (DM), dyslipidemia were the top three affecting GC patients. A significant association ( p  < 0.05) between ABO BG and serous histology in endometrial cancer was found. ABO blood group and fallopian cancer showed a significant relationship between serous histology and B blood group ( p  < 0.05). For ovarian cancer a significant association between AB blood group and recurrence rates were found ( p  < 0.05). In case of the patient dependent GCs, a significant association between ovarian cancers and recurrence, fallopian tube cancers and adverse events and survival status, vaginal/vulval cancers and TNM stage and mixed GCs and tumor type (carcinoma) was observed ( P  < 0.05). Furthermore, multinomial analysis between various confounding factors and GCs revealed that the risk of Cervical, Endometrial and Ovarian cancers to be significant for Type B BG ( P  < 0.05). Conclusion Our study found that O + BG was the most prevalent among our population. Furthermore, there was a significant association between BG B and endometrial and serous histology in fallopian tube and between BG AB and ovarian malignancies, respectively. Additionally, multinomial analysis revealed higher risk of Cervical, Endometrial and Ovarian cancers for Type B BG ( P  < 0.05).

Pain is a global health issue that affects an individual's quality of life. Its alleviation and management will enhance patients' experience. Community pharmacists can help manage pain severity through their valuable roles in medical teams and by managing the consequences of pain. This study aimed to evaluate community pharmacists' knowledge and attitudes toward pain and pain management in Saudi Arabia. A cross-sectional study was performed to evaluate community pharmacists' knowledge and attitudes toward pain and pain management in Saudi Arabia. Pharmacists aged ≥ 21 years, with a degree in pharmacy were included in this study. Each respondent participated in an online survey covering cancer-oriented pain and assessment of pain; pharmacology; abuse of substances; and physical dependence. An independent -test and One-way ANOVA, with least significant difference as a post-hoc test, were employed, in addition to the General Linear Regression Model using Main Effect as the model. This study revealed that the pain-related knowledge and attitude among community pharmacists in Saudi Arabia were inadequate. Age (p = 0.003), work experience (p = 0.036), nature of work (p = 0.001), and work location (p = 0.003) were determined as significant factors affecting their overall knowledge and attitude toward pain. Overall, attempts to expand community pharmacists' knowledge and foster an appropriate attitude toward pain management among them in Saudi Arabia are highly recommended. Additional academic courses, studies, and tailored neuroscience courses will improve their awareness and knowledge of pain and pain management.

In this study, the static deflection of non-prismatic axial function graded tapered beam (A-FGB) under distribution load has been analyzed using ANSYS workbench (17.2). According to a power-law model, the elastic modulus of the beam varies continuously in the axial direction of the beam. Also, the beam’s geometry, i.e., width, thickness, or both width and thickness of the beam, varies linearly in the axial direction with different values of non-uniformity parameter (1, 0.5,0, −0.5, and −0.75). The effects of martial distribution, i.e., power-law index, and non-uniformity parameter on the static deflection for A-FGB with different boundary conditions, in such free-clamped, clamped-free, and simply-supported, are studied. This research deals with functionally graded materials FGMs in more than one aspect in terms of using different boundary conditions; in addition, it studies the response of the non-prismatic beam non-uniformity parameter (α); therefore, this research studies comprehensively the deflection of the beam. The results show that the increase in power-law index causes decreasing in dimensionless deflection and its rate of change depends on the supporting types of the beam and non-uniformity parameters. The variation in both width and thickness for a free-clamped axial function–graded beam gives a significant decrease in dimensionless deflection at decreasing in non-uniformity parameter, whereas the variation in thickness for clamped-free axial function graded beam gives a significant decrease in dimensionless deflection at decreasing of non-uniformity parameter.

During the global pandemic, the proliferation of unstructured data has led to the increased prominence of Health Informatics, physicians, nurses, and medical administration. This enables healthcare units to utilize and derive significant insights for doctors and decision-makers, providing pertinent information to enhance operations and forecast future treatment modalities through Information Systems Communication. Currently, vast quantities of data are being gathered and analyzed globally to enhance patient diagnosis and treatment, improve public health systems, and aid government agencies in formulating and executing public health policies, thereby fostering confidence in future generations seeking superior public health systems. Hospitals must be equipped to adeptly address forthcoming epidemics. A thorough epidemic management strategy is essential to mitigate the epidemic's impact, limit public health risks, and ensure efficient and effective resource allocation.