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"Albert, Daniel"
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Victus : the fall of Barcelona
\"A sweeping tale of heroism, treason, war, love, pride, and regret that culminates in the tragic fall of a legendary city, illustrated with battle diagrams, portraits of political figures, and priceless maps of the old city of Barcelona.\"--Publisher's website.
Book
Bite First, Bleed Later: How Philippine Trimeresurus Pit Viper Venoms Hijack Blood Clotting
The Philippines has a high diversity of venomous snake species, but there is minimal information on their envenomation effects. This is evidenced by the small number of case reports, the poor reporting of envenomation cases, and the absence of specific antivenoms apart from one against the Philippine cobra (Naja philippinensis). This study sought to profile the action of selected Philippine pit viper venoms on blood coagulation and to investigate whether commercially available non-specific antivenoms can provide adequate protection against these venoms. Venom from the pit vipers Trimeresurus flavomaculatus and Trimeresurus mcgregori were subjected to coagulation assays, antivenom cross-neutralization tests, and thromboelastography. Venoms from both species were able to clot human plasma and isolated human fibrinogen. Consistent with pseudo-procoagulant/thrombin-like activity, the resulting fibrin clots were weak and transient, thereby contributing to net anticoagulation through the depletion of fibrinogen levels. Clotting factors fIXa and fXa were also inhibited by the venoms, further contributing to the net anticoagulant activity. Monovalent and polyvalent antivenoms from the Thai Red Cross Society were effective against both venoms, indicating cross-neutralization of venom toxins; the polyvalent antivenom was able to rescue fibrinogen clotting to a greater degree than the monovalent antivenom. Our findings highlight the coagulopathic effects of these pit viper venoms and suggest the utility of procuring the non-specific antivenoms for areas in the Philippines with a high risk for pit viper envenomation.
Journal Article
EnVision algebra 1
\"EnVision A G A ©2018 is a brand-new high school mathematics program. It includes Algebra 1, Geometry, and Algebra 2. enVision A G A helps students look at math in new ways, with engaging, relevant, and adaptive content. For teachers, the program offers a flexible choice of options and resources. Customize instruction, practice, and assessments. Re-energize students and help them become more self-directed and independent learners\"--Provided by publisher
Book
Spatial Structure and Activity of Sedimentary Microbial Communities Underlying a Beggiatoa spp. Mat in a Gulf of Mexico Hydrocarbon Seep
Subsurface fluids from deep-sea hydrocarbon seeps undergo methane- and sulfur-cycling microbial transformations near the sediment surface. Hydrocarbon seep habitats are naturally patchy, with a mosaic of active seep sediments and non-seep sediments. Microbial community shifts and changing activity patterns on small spatial scales from seep to non-seep sediment remain to be examined in a comprehensive habitat study.
We conducted a transect of biogeochemical measurements and gene expression related to methane- and sulfur-cycling at different sediment depths across a broad Beggiatoa spp. mat at Mississippi Canyon 118 (MC118) in the Gulf of Mexico. High process rates within the mat ( approximately 400 cm and approximately 10 cm from the mat's edge) contrasted with sharply diminished activity at approximately 50 cm outside the mat, as shown by sulfate and methane concentration profiles, radiotracer rates of sulfate reduction and methane oxidation, and stable carbon isotopes. Likewise, 16S ribosomal rRNA, dsrAB (dissimilatory sulfite reductase) and mcrA (methyl coenzyme M reductase) mRNA transcripts of sulfate-reducing bacteria (Desulfobacteraceae and Desulfobulbaceae) and methane-cycling archaea (ANME-1 and ANME-2) were prevalent at the sediment surface under the mat and at its edge. Outside the mat at the surface, 16S rRNA sequences indicated mostly aerobes commonly found in seawater. The seep-related communities persisted at 12-20 cm depth inside and outside the mat. 16S rRNA transcripts and V6-tags reveal that bacterial and archaeal diversity underneath the mat are similar to each other, in contrast to oxic or microoxic habitats that have higher bacterial diversity.
The visual patchiness of microbial mats reflects sharp discontinuities in microbial community structure and activity over sub-meter spatial scales; these discontinuities have to be taken into account in geochemical and microbiological inventories of seep environments. In contrast, 12-20 cm deep in the sediments microbial communities performing methane-cycling and sulfate reduction persist at lower metabolic rates regardless of mat cover, and may increase activity rapidly when subsurface flow changes.
Journal Article
Justice League Rebirth deluxe edition
\"Exploding from the pages of the blockbuster DC Universe Rebirth event, this deluxe edition collects the first eleven issues of the acclaimed series and the Rebirth special that started it, all together in one hardcover volume for the first time! Superman. Batman. Wonder Woman. The Flash. Cyborg. Green Lantern. They're more than just a team of superheroes. They're the Justice League...and they're about to enter a whole new era! The Superman these incredible heroes once knew is dead, leaving an older, wiser Man of Steel from a vanished universe to take up the fight against evil. Hal Jordan, the greatest of the Green Lanterns, has taken to the stars, entrusting his place in the League to his powerful but untested young proteges, Jessica Cruz and Simon Baz. Now the Justice League must get used to these new faces and learn to work as a team once more. But they'd better do it fast. They're about to confront the biggest threats they've ever faced, from godlike machines capable of converting all life on Earth into a weapon, to a humble hacker who's ready to hit them where it hurts most.\"-- Provided by publisher.
Book
A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies
MCL-1 is one of the most frequently amplified genes in cancer, facilitating tumor initiation and maintenance and enabling resistance to anti-tumorigenic agents including the BCL-2 selective inhibitor venetoclax. The expression of MCL-1 is maintained via P-TEFb-mediated transcription, where the kinase CDK9 is a critical component. Consequently, we developed a series of potent small-molecule inhibitors of CDK9, exemplified by the orally active A-1592668, with CDK selectivity profiles that are distinct from related molecules that have been extensively studied clinically. Short-term treatment with A-1592668 rapidly downregulates RNA pol-II (Ser 2) phosphorylation resulting in the loss of MCL-1 protein and apoptosis in MCL-1-dependent hematologic tumor cell lines. This cell death could be attenuated by either inhibiting caspases or overexpressing BCL-2 protein. Synergistic cell killing was also observed between A-1592668 or the related analog A-1467729, and venetoclax in a number of hematologic cell lines and primary NHL patient samples. Importantly, the CDK9 inhibitor plus venetoclax combination was well tolerated in vivo and demonstrated efficacy superior to either agent alone in mouse models of lymphoma and AML. These data indicate that CDK9 inhibitors could be highly efficacious in tumors that depend on MCL-1 for survival or when used in combination with venetoclax in malignancies dependent on MCL-1 and BCL-2.
Journal Article
Jacques Daviel (1696–1762) and the Competition to Extract Cataracts: A Reappraisal
To analyze the timing and interactions among Jacques Daviel (1696-1762) and other Paris-based surgeons who pursued cataract extraction in the mid-18
century.
Historical books, newspapers, and manuscripts were reviewed.
The claim of English oculist John Taylor that his visit to Daviel's hometown of Marseille in 1734 inspired Daviel to become an ophthalmologist is supported by contemporaneous evidence. In 1745, while in Marseille, Jacques Daviel switched from a single-instrument couching technique to a two-instrument technique. By September of 1748, while in Paris, Daviel had extracted remnants of a cataract from the posterior chamber following a failed couching. On July 1, 1750, a surgeon and monk named Jean Baseilhac (1703-1781), known as Frère Côme, was said to have performed cataract extraction through an incision in the center of the cornea. On July 3, 1750, in Paris, surgeon Natale Pallucci (1719-1797), made a corneal incision and extracted from the posterior chamber cataract fragments which remained after couching. For four months, beginning on July 7, 1750, in Leuven, Daviel experimented with planned cataract extraction in animals. On Sep. 18, 1750, in Cologne, Daviel performed a planned, primary cataract extraction on a cleric named Gilles Noupres.
Jacques Daviel became an ophthalmologist in 1734 and secondarily extracted lens fragments by 1748. Three Paris-based eye surgeons, including Daviel, pursued the development of cataract extraction beginning in the first week of July 1750. The first contemporaneously documented planned cataract extraction through an incision was performed by Daviel in Cologne on Sep. 18, 1750.
Three Paris-based surgeons, including Jacques Daviel, began to pursue cataract extraction in the first week of July 1750.
Journal Article
Divergent decennial trends in mental health according to age reveal poorer mental health for young people: repeated cross-sectional population-based surveys from the HUNT Study, Norway
ObjectivesPublic health trends are formed by political, economic, historical and cultural factors in society. The aim of this paper was to describe overall changes in mental health among adolescents and adults in a Norwegian population over the three last decades and discuss some potential explanations for these changes.DesignRepeated population-based health surveys to monitor decennial changes.SettingData from three cross-sectional surveys in 1995–1997, 2006–2008 and 2017–2019 in the population-based HUNT Study in Norway were used.ParticipantsThe general population in a Norwegian county covering participants aged 13–79 years, ranging from 48 000 to 62 000 000 in each survey.Main outcome measuresPrevalence estimates of subjective anxiety and depression symptoms stratified by age and gender were assessed using the Hopkins Symptom Checklist-5 for adolescents and the Hospital Anxiety and Depression Scale for adults.ResultsAdolescents’ and young adults’ mental distress increased sharply, especially between 2006–2008 and 2017–2019. However, depressive symptoms instead declined among adults aged 60 and over and anxiety symptoms remained largely unchanged in these groups.ConclusionsOur trend data from the HUNT Study in Norway indicate poorer mental health among adolescents and young adults that we suggest are related to relevant changes in young people’s living conditions and behaviour, including the increased influence of screen-based media.
Journal Article
Anaerobic oxidation of methane at different temperature regimes in Guaymas Basin hydrothermal sediments
Anaerobic oxidation of methane (AOM) was investigated in hydrothermal sediments of Guaymas Basin based on δ
13
C signatures of CH
4
, dissolved inorganic carbon and porewater concentration profiles of CH
4
and sulfate. Cool, warm and hot
in-situ
temperature regimes (15–20 °C, 30–35 °C and 70–95 °C) were selected from hydrothermal locations in Guaymas Basin to compare AOM geochemistry and 16S ribosomal RNA (rRNA),
mcrA
and
dsrAB
genes of the microbial communities. 16S rRNA gene clone libraries from the cool and hot AOM cores yielded similar archaeal types such as Miscellaneous Crenarchaeotal Group, Thermoproteales and anaerobic methane-oxidizing archaea (ANME)-1; some of the ANME-1 archaea formed a separate 16S rRNA lineage that at present seems to be limited to Guaymas Basin. Congruent results were obtained by
mcrA
gene analysis. The warm AOM core, chemically distinct by lower porewater sulfide concentrations, hosted a different archaeal community dominated by the two deep subsurface archaeal lineages Marine Benthic Group D and Marine Benthic Group B, and by members of the Methanosarcinales including ANME-2 archaea. This distinct composition of the methane-cycling archaeal community in the warm AOM core was confirmed by
mcrA
gene analysis. Functional genes of sulfate-reducing bacteria and archaea,
dsrAB
, showed more overlap between all cores, regardless of the core temperature. 16S rRNA gene clone libraries with Euryarchaeota-specific primers detected members of the
Archaeoglobus
clade in the cool and hot cores. A V6-tag high-throughput sequencing survey generally supported the clone library results while providing high-resolution detail on archaeal and bacterial community structure. These results indicate that AOM and the responsible archaeal communities persist over a wide temperature range.
Journal Article