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"Alcorn, Stephen"
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A gift of days : the greatest words to live by
\"Daily words of inspiration from 366 visionaries who have shaped our world.\"--P. [4] of cover.
Book
Analysis and Intuition: Reflections on the Mystic Union of Measure and Abandon in the Art of Figure Drawing
Is it not the illogical totality, the mystic union of the blot and the blueprint, or the instinctive and the rational, which has given true art its significance?Since being invited to teach at Virginia Commonwealth University's School of the Arts in the fall of 2010, this has been my primary objective.[...]paradoxically, rather than engage in what has been known for centuries as the practice of life drawing, students can find themselves forced to engage in a sort of death drawing.The semester-long, incremental transition from analytical processes of transcription to increasingly intuitive mark-making practices culminates with a visit to the Department of Dance and Choreography, where students are challenged to draw dance majors as they train and rehearse-in a word, to draw the human figure in perpetual motion.[...]students experience the antithesis of the inanimate, static approach that has come to define the conventional figure drawing instruction and, in the process, are introduced to drawing at the speed of sight.[...]the professor comes to have a great deal more respect for the challenges that students face as they complete their rigorous assignments.
Journal Article
Drawing the line: reflections on the importance of drawing by hand in an increasingly digital age
What has emerged from the predominance of the computer in the generation of art is the domination of the tool over the aesthetic judgment of the user, The computer is an extremely powerful instrument, and like all tools, it alters our perception of reality. Because of this, one's consciousness of form, color, shape, and meaning can risk the danger of being eclipsed by increasingly technological extensions of our faculties. Just as the printed book did not eclipse the handwritten letter, and just as the television did not eliminate film, art never truly died, despite having being momentarily suffocated by qualitative relativism. Since time immemorial artisans, artists, architects, designers, and engineers of all kinds have expressed themselves first, and most intuitively, through the infinitely rich and varied medium of drawing.
Journal Article
To solve a deadly shortage: economic incentives for human organ donation
In this article Dr. Harris and attorney Alcorn propose the establishment of a governmentally regulated, posthumous organ market, with economic incentives for the donors, in order to increase the supply of transplantable organs. The authors review transplant technology, provide a short history of donation and sale of organs, tissues, and cells, discuss the various legislative approaches that have been made to increase the supply of organs, and analyze the problems with the open market approach. They conclude with a proposal for a regulated posthumous organ market.
Journal Article
To Solve a Deadly Shortage: Economic Incentives for Human Organ Donation
Currently 68,000 Americans are waiting for an organ donation, with a
name added to the list every 16 minutes. Twelve Americans die every day
because a needed vital organ is not available. e congressional answer has
been the Uniform Anatomical Gi¬ Act, which was designed to promote public awareness and health care provider education, and to prohibit the sale of
most human organs.1
Book Chapter
The Farm
\"A poetic appreciation of life on the farm. The latest in\" Audubon's \"series, On Home Ground\".
Magazine Article
Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study
AbstractObjectiveTo evaluate whether early initiation of prophylactic anticoagulation compared with no anticoagulation was associated with decreased risk of death among patients admitted to hospital with coronavirus disease 2019 (covid-19) in the United States.DesignObservational cohort study.SettingNationwide cohort of patients receiving care in the Department of Veterans Affairs, a large integrated national healthcare system.ParticipantsAll 4297 patients admitted to hospital from 1 March to 31 July 2020 with laboratory confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and without a history of anticoagulation.Main outcome measuresThe main outcome was 30 day mortality. Secondary outcomes were inpatient mortality, initiating therapeutic anticoagulation (a proxy for clinical deterioration, including thromboembolic events), and bleeding that required transfusion.ResultsOf 4297 patients admitted to hospital with covid-19, 3627 (84.4%) received prophylactic anticoagulation within 24 hours of admission. More than 99% (n=3600) of treated patients received subcutaneous heparin or enoxaparin. 622 deaths occurred within 30 days of hospital admission, 513 among those who received prophylactic anticoagulation. Most deaths (510/622, 82%) occurred during hospital stay. Using inverse probability of treatment weighted analyses, the cumulative incidence of mortality at 30 days was 14.3% (95% confidence interval 13.1% to 15.5%) among those who received prophylactic anticoagulation and 18.7% (15.1% to 22.9%) among those who did not. Compared with patients who did not receive prophylactic anticoagulation, those who did had a 27% decreased risk for 30 day mortality (hazard ratio 0.73, 95% confidence interval 0.66 to 0.81). Similar associations were found for inpatient mortality and initiation of therapeutic anticoagulation. Receipt of prophylactic anticoagulation was not associated with increased risk of bleeding that required transfusion (hazard ratio 0.87, 0.71 to 1.05). Quantitative bias analysis showed that results were robust to unmeasured confounding (e-value lower 95% confidence interval 1.77 for 30 day mortality). Results persisted in several sensitivity analyses.ConclusionsEarly initiation of prophylactic anticoagulation compared with no anticoagulation among patients admitted to hospital with covid-19 was associated with a decreased risk of 30 day mortality and no increased risk of serious bleeding events. These findings provide strong real world evidence to support guidelines recommending the use of prophylactic anticoagulation as initial treatment for patients with covid-19 on hospital admission.
Journal Article
Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Nebulized Sodium Nitrite (AIR001) Following Repeat-Dose Inhalation in Healthy Subjects
Introduction
The efficacy of nebulized sodium nitrite (AIR001) has been demonstrated in animal models of pulmonary arterial hypertension (PAH), but it was not known if inhaled nitrite would be well tolerated in human subjects at exposure levels associated with efficacy in these models.
Methods
Inhaled nebulized sodium nitrite was assessed in three independent studies in a total of 82 healthy male and female subjects. Study objectives included determination of the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) under normal and mildly hypoxic conditions, and following co-administration with steady-state sildenafil, assessment of nitrite pharmacokinetics, and evaluation of the fraction exhaled nitric oxide (FE
NO
) and concentrations of iron-nitrosyl hemoglobin (Hb(Fe)-NO) and
S
-nitrosothiols (
R
-SNO) as biomarkers of local and systemic NO exposure, respectively.
Results
Nebulized sodium nitrite was well tolerated following 6 days of every 8 h administration up to 90 mg, producing significant increases in circulating Hb(Fe)-NO,
R
-SNO, and FE
NO
. Pulmonary absorption of nitrite was rapid and complete, and plasma exposure dose was proportional through the MTD dosage level of 90 mg, without accumulation following repeated inhalation. At higher dosage levels, DLTs were orthostasis (observed at 120 mg) and hypotension with tachycardia (at 176 mg), but venous methemoglobin did not exceed 3.0 % at any time in any subject. Neither the tolerability nor pharmacokinetics of nitrite was impacted by conditions of mild hypoxia, or co-administration with sildenafil, supporting the safe use of inhaled nitrite in the clinical setting of PAH.
Conclusion
On the basis of these results, nebulized sodium nitrite (AIR001) has been advanced into randomized trials in PAH patients.
Journal Article