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"Alderton, Gemma K."
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Epigenetic and genetic heterogeneity in metastasis
How similar are metastases to the primary tumour and other metastases in the same patient? And what does that tell us about the evolution of metastatic ability? Two papers investigated these questions in pancreatic ductal adenocarcinoma (PDAC).
Journal Article
Metastasis. Exosomes drive premetastatic niche formation
Peinado and colleagues find that exosomes produced by tumour cells can mediate premetastatic niche formation.Peinado and colleagues find that exosomes produced by tumour cells can mediate premetastatic niche formation.
Journal Article
Feeding the TCA cycle in vivo
Two papers assess the role of glucose in lung cancer metabolismin vivo.
Journal Article
Directions to metastatic sites
Why do some cancers only metastasize to certain organs? This question of organotropism is perplexing, and a team led by Lyden, Bromberg and Peinado have found that exosomes could be key.
Journal Article
Cancer as a symptom of evolution?
A paper inScienceby Tomasetti, Li and Vogelstein develops their 'bad luck' model further and explores how different sources of DNA mutation influence different cancer types.
Journal Article
FBP1 is suppressed in kidney tumours
Liet al. find that fructose-1,6-bisphosphatase 1 (FBP1) levels are uniformly reduced in clear cell renal cell carcinoma (ccRCC), identifying a new mechanism of metabolic reprogramming in this cancer type.
Journal Article