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The Keret River is one of large salmon rivers in the White Sea basin. The estimated abundance of Atlantic salmon in the river began to decrease in 1991, reaching a maximum in 1997 due to the abruptly increased illegal fishing level and the invasion of juvenile Atlantic salmon by the monogeny of Gyrodactylus salaris. The studies conducted have shown that the salmon population in the Keret River is depressed and that the average distribution density of juveniles aged 1+ and older is 1.6 fish / 100 m2. Atlantic salmon reproduction on fish hatcheries is important for maintaining the population abundance (farm individuals make up over 50% of the population). Artificial Atlantic salmon reproduction in the Republic of Karelia’s rivers is carried out by the Karelian Branch of Glavrybvod FGBU at the Kem and Vyg fish hatcheries. The fish hatcheries could achieve better results by updating the juvenile breeding technology. An example of a new high-intensity biotechnology is the use of physical factors controlling the vital activity of fish in the various periods of ontogenesis. The study of the effect of low-intensity laser radiation in the early stages of ontogenesis has shown that red light over a certain dose range enhances the adaptability of fish by decreasing mortality and accelerating growth, thus decreasing the loss of fish products in fish hatcheries.

In the Kola River (Kola Peninsula), on the basis of cluster analysis of long-term density data in the nursery areas of underyearlings, wild and wild + hatchery parr of Atlantic salmon Salmo salar L., four clusters have been identified in each group of juveniles with high, medium, low, and very low density. In the lower and upper reaches of the river, areas were identified where the state of salmon reproduction can be assessed as critical. The article discusses the role of illegal, unreported, unregulated fishing, ulcerative dermal necrosis and hatchery reproduction as possible reasons for the decline in the reproductive potential of one of the most significant salmon rivers in the region.

The results of a comparative analysis of the efficiency of the artificial reproduction of Atlantic salmon ( Salmo salar ) individuals released to the Kola River at ages of 3 years (1980–2002) and 1 year (2003–2017) are given. After the fish hatcheries began to release artificially reared anadromous salmon individuals at the age of 1 year, their qualitative parameters did not significantly change. The value of the commercial return became somewhat lower for the released yearlings than for the 3-year-old individuals; however, it remained satisfactorily high. It is recommended to reduce the release volume to avoid the overpopulation of juveniles; it is also suggested to evenly distribute them over the nursery grounds that are most suitable for their adaptation and select spawners for broodstock according to the historically established subpopulation structure.

The process of adaptation of the yearling Atlantic salmon Salmo salar cultured under the farming conditions in the Umba fish hatchery to the natural environments has been studied during a 1-year period after releasing them into the river. The significant differences in a range of the morphophysiological parameters between the hatchery-reared juveniles and their wild-origin peers, which were revealed immediately before the release into the river and 1 month later, are gradually reduced. The index of body condition, the liver index, and the body cavity fat content are normalized 4 months later; 13 months later, the other analyzed parameters (the hemoglobin concentration and the indices of heart, gills, and pectoral fins) are brought back into the normal ranges. The behavioral patterns of the hatchery-reared and wild-origin juveniles remain different during the whole observation period, since the behavioral habits acquired under the farming conditions, when compared to the developmental abnormalities, more commonly affect the juvenile fish survival in the natural environments.

Analysis of long-term fishing and biological data has made it possible to determine the proportion of respawning individuals (the “remainder”) in populations of Atlantic salmon Salmo salar inhabiting large rivers of the Kola Peninsula. The contribution of respawning individuals to the dynamics of the Atlantic salmon population was assessed using the mathematical simulation model. It is shown that the model population becomes more resistant to fishing with increase in the “remainder” proportion; however, the influence of such individuals on the population dynamics is noticeable only when their relative number is more than 5% in the spawning population. The results of different model experiments are interpreted. The role of respawning salmons may be determined not so much by their quantitative contribution to the reproduction process as by the maintenance of the genetic diversity of the population within the reproductive strategy characteristic of the Atlantic salmon.

The comparison was made of the physiological state of young Atlantic salmons Salmo salar of the same age from natural and artificial reproduction. Qualitative and quantitative parameters of blood and a wide range of observed pathologies of alimentary origin suggested that the health of juveniles grown at the Umba Fish Hatchery (UFH) could not be considered satisfactory, and the survival of fish from the fish hatchery released to the river would be low. It was shown that the physiological state of juveniles obtained under artificial conditions grew much worse with age. Physiological parameters of 2-year-old juveniles came to norm during several months after their release. Visible pathological changes in the 3-year-old individuals were apparently irreversible. Analysis of data obtained led to the conclusion that complex researches are necessary in UFH to correct the diet, composition and quality of forage, and the sanitary-epizootological control of the fish-cultural process. Additionally, it seems to be expedient to convert UFH to the releasing of 2-year-old juveniles.

Gut microbiota of patients with Parkinson’s disease and healthy volunteers was analyzed by the method of high throughput 16S rRNA sequencing of bacterial genomes. In patients with Parkinson’s diseases, changes in the content of 9 genera and 15 species of microorganisms were revealed: reduced content of Dorea , Bacteroides , Prevotella , Faecalibacterium , Bacteroides massiliensis , Stoquefichus massiliensis , Bacteroides coprocola , Blautia glucerasea , Dorea longicatena , Bacteroides dorei , Bacteroides plebeus , Prevotella copri , Coprococcus eutactus , and Ruminococcus callidus , and increased content of Christensenella , Catabacter , Lactobacillus , Oscillospira , Bifidobacterium , Christensenella minuta , Catabacter hongkongensis , Lactobacillus mucosae , Ruminococcus bromii , and Papillibacter cinnamivorans . This microbiological pattern of gut microflora can trigger local inflammation followed by aggregation of α-synuclein and generation of Lewy bodies.

Influence of water in the different states on a structure and dielectric properties of microcrystalline cellulose were studied by of X-ray, thermogravimetry, and dielectric spectroscopy. At research of microcrystalline cellulose (MCC) with different content of water, it is shown that the molecules of water are located in the macropores of MCC and in multimolecular hydrated layers. It is shown that at the increase of concentration of water in a hydrated shell, the reorganization of molecules of cellulose in the surface of crystallites takes place, and as a result, their transversal size and crystallinity increase. It is shown that during the concentration of water, more than 13% in a continuous hydrated shell of crystallites appears. Temperature dependences of actual and imaginary parts of complex dielectric permittivity were studied in the interval of temperatures [−180 ÷ 120] °C on frequencies of f  = 5, 10, 20, and 50 kHz. A low-temperature relaxation process and high-temperature transition were observed. Low-temperature relaxation process which is related to transition of surface methylol groups of molecules of cellulose conformation from tg to tt is shifted toward low temperatures at the increase of concentration of water in microcrystalline cellulose.

Survival outcomes are poor for patients with metastatic urothelial carcinoma who receive standard, first-line, platinum-based chemotherapy. We assessed the overall survival of patients who received durvalumab (a PD-L1 inhibitor), with or without tremelimumab (a CTLA-4 inhibitor), as a first-line treatment for metastatic urothelial carcinoma. DANUBE is an open-label, randomised, controlled, phase 3 trial in patients with untreated, unresectable, locally advanced or metastatic urothelial carcinoma, conducted at 224 academic research centres, hospitals, and oncology clinics in 23 countries. Eligible patients were aged 18 years or older with an Eastern Cooperative Oncology Group performance status of 0 or 1. We randomly assigned patients (1:1:1) to receive durvalumab monotherapy (1500 mg) administered intravenously every 4 weeks; durvalumab (1500 mg) plus tremelimumab (75 mg) administered intravenously every 4 weeks for up to four doses, followed by durvalumab maintenance (1500 mg) every 4 weeks; or standard-of-care chemotherapy (gemcitabine plus cisplatin or gemcitabine plus carboplatin, depending on cisplatin eligibility) administered intravenously for up to six cycles. Randomisation was done through an interactive voice–web response system, with stratification by cisplatin eligibility, PD-L1 status, and presence or absence of liver metastases, lung metastases, or both. The coprimary endpoints were overall survival compared between the durvalumab monotherapy versus chemotherapy groups in the population of patients with high PD-L1 expression (the high PD-L1 population) and between the durvalumab plus tremelimumab versus chemotherapy groups in the intention-to-treat population (all randomly assigned patients). The study has completed enrolment and the final analysis of overall survival is reported. The trial is registered with ClinicalTrials.gov, NCT02516241, and the EU Clinical Trials Register, EudraCT number 2015-001633-24. Between Nov 24, 2015, and March 21, 2017, we randomly assigned 1032 patients to receive durvalumab (n=346), durvalumab plus tremelimumab (n=342), or chemotherapy (n=344). At data cutoff (Jan 27, 2020), median follow-up for survival was 41·2 months (IQR 37·9–43·2) for all patients. In the high PD-L1 population, median overall survival was 14·4 months (95% CI 10·4–17·3) in the durvalumab monotherapy group (n=209) versus 12·1 months (10·4–15·0) in the chemotherapy group (n=207; hazard ratio 0·89, 95% CI 0·71–1·11; p=0·30). In the intention-to-treat population, median overall survival was 15·1 months (13·1–18·0) in the durvalumab plus tremelimumab group versus 12·1 months (10·9–14·0) in the chemotherapy group (0·85, 95% CI 0·72–1·02; p=0·075). In the safety population, grade 3 or 4 treatment-related adverse events occurred in 47 (14%) of 345 patients in the durvalumab group, 93 (27%) of 340 patients in the durvalumab plus tremelimumab group, and in 188 (60%) of 313 patients in the chemotherapy group. The most common grade 3 or 4 treatment-related adverse event was increased lipase in the durvalumab group (seven [2%] of 345 patients) and in the durvalumab plus tremelimumab group (16 [5%] of 340 patients), and neutropenia in the chemotherapy group (66 [21%] of 313 patients). Serious treatment-related adverse events occurred in 30 (9%) of 345 patients in the durvalumab group, 78 (23%) of 340 patients in the durvalumab plus tremelimumab group, and 50 (16%) of 313 patients in the chemotherapy group. Deaths due to study drug toxicity were reported in two (1%) patients in the durvalumab group (acute hepatic failure and hepatitis), two (1%) patients in the durvalumab plus tremelimumab group (septic shock and pneumonitis), and one (<1%) patient in the chemotherapy group (acute kidney injury). This study did not meet either of its coprimary endpoints. Further research to identify the patients with previously untreated metastatic urothelial carcinoma who benefit from treatment with immune checkpoint inhibitors, either alone or in combination regimens, is warranted. AstraZeneca.

The DANSS detector (Alekseev et al. in JINST 11:P11011, 2016) is located directly below a commercial reactor core at the Kalinin Nuclear Power Plant. Such a position provides an overburden about 50 m.w.e. in vertical direction. In terms of the cosmic rays it occupies an intermediate position between surface and underground detectors. The sensitive volume of the detector is a cubic meter of plastic scintillator with fine segmentation and combined PMT and SiPM readout, surrounded by multilayer passive and active shielding. The detector can reconstruct muon tracks passing through its sensitive volume. The main physics goal of the DANSS experiment implies the antineutrino spectra measurements at various distances from the source. This is achieved by means of a lifting platform so that the data is taken in three positions – 10.9, 11.9 and 12.9 meters from the reactor core. The muon data were collected for nearly four calendar years. The overburden parameters ⟨Ethrcosθ⟩ and ⟨Ethr⟩, as well as the temperature and barometric correlation coefficients are evaluated separately for the three detector positions and, in each position, in three ranges of the zenith angle – for nearly vertical muons with cosθ>0.9, for nearly horizontal muons with cosθ<0.36, and for the whole upper hemisphere.