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\"Zarathustra Must Die is a fictional memoir of a graduate student's odyssey through the thought of Friedrich Nietzsche-a journey that is far more than purely intellectual. Through many states of consciousness, Dorian Alexander finally comes to realize the nature of time and its role in human existence. Dorian Alexander is the pen name of a prominent philosopher and scientist. Zarathustra Must Die is Alexander's first work of fiction and reflects his longtime fascination with the work of Nietzsche. \"-- Provided by publisher.

Background The Focused Assessment with Sonography for Trauma (FAST) examination using conventional ultrasound has limited utility for detecting solid organ injury. Therefore, this systematic review and meta-analysis compares the performance of contrast-enhanced ultrasound (CEUS) to conventional ultrasound when used as the initial assessment for abdominal trauma prior to computed tomography (CT) imaging. Methods A systematic literature search of major databases was conducted of human studies investigating the diagnostic accuracy of conventional ultrasound and CEUS occurring prior to CT imaging for abdominal trauma. The study followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. The quality of studies was evaluated using the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies 2) tool. Paired pooled sensitivity and specificity between conventional ultrasound and CEUS were compared using data extracted from the eligible studies. Diagnostic odds ratio, number needed to diagnose values, and likelihood ratios were also determined. Results Ten studies were included. More than half of the included studies demonstrated low risk of bias. Using McNemar’s test to assess for paired binary observations, we found that CEUS had statistically higher sensitivity (0.933 vs. 0.559; two-tailed, P  < 0.001) and specificity (0.995 vs. 0.979; two-tailed, P  < 0.001) than conventional ultrasound in the setting of abdominal trauma, respectively. When divided into particular findings of clinical interest, CEUS had statistically higher sensitivity than conventional ultrasound in screening for active bleeding and injuries to all abdominal solid organs. CEUS also had superior diagnostic odds ratios, number needed to diagnose values, and likelihood ratios than conventional ultrasound. Conclusion The diagnostic value of CEUS was higher than that of conventional ultrasound for differentiating traumatic abdominal injuries when used as the initial assessment in the emergency department.

This project reads through Samuel R. Delany’s Nevèrÿon series as a means of conceptualizing a distinctly revolutionary fantastic. To begin, I establish the fantastic as a specific literary function and outline how it has been studied in relation to the genre of Fantasy. Further, I distinguish the revolutionary fantastic from the category of Radical Fantasy based on the former’s resistance to categorizations that impose a definitive fictionality. Relying on the work of thinkers like José Muñoz and Gloria Anzaldúa, I propose the revolutionary fantastic as an affective, queer, and decolonial practice of making belief related to contemporary esoterism but more attuned to the political poetics of queer of color critique. Through Delany, I evoke the figure of the Barbarian as a queerly racialized anachronism emblematic of the revolutionary fantastic’s deconstructive processes. With a specific focus on the Barbarian’s enmeshment in a pastness distinct from the discipline of history, I position this figure as a model for temporal fugitivity that offers a broader revolutionary imaginary by way of fisting theory. In this reading of Delany, I also assemble the crypt as a marginal zone from which the border between reality and unreality may be trespassed, speaking to the revolutionary potential of such trespassing and meditating on the tragic affect of its inevitable failure as a way of showcasing the reconstructive elements of the project’s titular formula. The project closes with a reading of C. L. Clark’s novel The Unbroken, where I demonstrate the applicability of the revolutionary fantastic as an approach to re-reading and re-writing our world(s).

Education is often positioned as a solution to incarceration while simultaneously using police (or commonly named School Resource Officers) to enforce discipline; or metal detectors and cameras for surveillance within school buildings as a measure of “safety” (Meiners, 2011). Sojoyner (2016) argues that both schools and prisons function as enclosures of Black life. Carceral progressivism positions education as a solution to societal oppression by “emancipating” students from enclosures, rather than actually abolishing the conditions that create said enclosures (Shange 2019). This is an example of how traditional education-based modes of study (Meyerhoff, 2019) enforce the carceral logics this work seeks to resist. This study is a phenomenological exploration of how pedagogies of abolition manifests in the everyday lives of Black trans folks. I define the phenomenon pedagogies of abolition as the process of teaching/learning an abolitionist praxis (Q. Alexander, 2022; Dyke et al., 2018; Love, 2019; Meiners, 2011; Rodriguez, 2019). Abolitionist praxis serves as a Black radical mode of study (Meyerhoff, 2019) working to transform our reliance on carceral state power and the logic that perpetuates it. This study specifically asks: how do pedagogies of abolition manifest in the everyday lives of Black trans folks? and how do those manifestations teach us how to study in abolitionist ways? Taking up a Black radical mode of study, this study uses a study group to create a fugitive network (Harney & Moten, 2013) of Black trans folks committed to abolition. The researcher studies with and alongside the group to articulate where and how these pedagogical moments manifest and work to shape our abolitionist world-making practices. This study explores three specific manifestations of pedagogies of abolition: relational ethic, embodied knowledge and holding change, both within the study group itself and in the lives of the participants. The three manifestations explored in this study illuminate the ways in which (modes of) study that center relationality, embodied ways of knowing and intentional building of collective spaces, create methods to enact an abolitionist praxis in our everyday lives. Grounded in the researcher’s experiences as a Black trans community educator, this research explores Black trans life as inherently pedagogical, teaching new ways of being and knowing that do not rely on carcerality, anti-Blackness, and gender based violence.

Polycyclic aromatic hydrocarbons (PAHs) are regarded as key molecules in the astrochemical evolution of the interstellar medium, but the formation mechanism of even their simplest prototype— naphthalene (C10H8)—has remained an open question. Here, we show in a combined crossed beam and theoretical study that naphthalene can be formed in the gas phase via a barrierless and exoergic reaction between the phenyl radical (C6H5) and vinylacetylene (CH2 = CH-C ≡ CH) involving a van-der-Waals complex and submerged barrier in the entrance channel. Our finding challenges conventional wisdom that PAH-formation only occurs at high temperatures such as in combustion systems and implies that low temperature chemistry can initiate the synthesis of the very first PAH in the interstellar medium. In cold molecular clouds, barrierless phenyl-type radical reactions could propagate the vinylacetylene-mediated formation of PAHs leading to more complex structures like phenanthrene and anthracene at temperatures down to 10 K.

Ultralight axion-like particles are well-motivated dark matter candidates, naturally emerging from theories of physics at ultrahigh energies. Here we report the results of a direct search for electromagnetic interactions of axion-like dark matter in the mass range that spans three decades from 12 peV to 12 neV. The detection scheme is based on a modification of Maxwell’s equations in the presence of axion-like dark matter that mixes with a static magnetic field to produce an oscillating magnetic field. The experiment makes use of toroidal magnets with ferromagnetic powder cores made of an iron–nickel alloy, which enhance the static magnetic field by a factor of 24. Using superconducting quantum interference devices, we achieve magnetic sensitivity of 150 aTHz−1/2, which is at the level of the most sensitive magnetic field measurements demonstrated with any broadband sensor. We recorded 41 h of data and improved the best limits on the magnitude of electromagnetic coupling constant for axion-like dark matter over a part of our mass range, at 20 peV reaching 4.0 × 10−11 GeV−1 (95% confidence level). Our measurements begin to explore the coupling strengths and masses of axion-like particles, where their mixing with photons could explain the anomalous transparency of the Universe to TeV γ-rays.The presence of axion-like dark matter candidates is expected to induce an oscillating magnetic field, enhanced by a ferromagnet. Limits on the electromagnetic coupling strength of axion-like particles are reported over a mass range spanning three decades.

VOLUNTEERS NEEDED FOR FITNESS PROGRAM A Concord certified fitness trainer is looking for men and women to embark on a 12-week holistic exercise and diet regimen that will be filmed this fall and aired on the town's cable access station. \"Concord Gets Fit\" will feature four Concord residents trained for one hour weekly by Ready, Set, Ggo! Fitness owner Lynne Lori Sylvan. There is no cost to volunteer, but those who do must commit to working out alone at least three more times a week. Sylvan said she will design a cardiovascular and weight-lifting program for all four volunteers. She will also teach them how to incorporate more grains, greens, and vegetables in their diet. Hypnosis will also be part of the regimen. Sylvan is also looking for volunteers to serve as her crew members. For more information, contact Sylvan at ready-set- ggoweightloss@comcast.net. - Jennifer Rosinski POLICE INVESTIGATE INDECENT EXPOSURES Lexington police are searching for suspects who have exposed themselves in at least five separate incidents since September, said Lieutenant Detective Joe O'Leary. Based on witness reports, there are from two to four suspects. The incidents have occurred on the Minuteman bike path, at Cary Memorial Library, and near Lexington High School. Police have posted composite sketches of the suspects online at ci.lexington.ma.us/Police/Police.htm. Anyone with information is asked to call 781-862-1212. - [Tania Ralli] COMMISSION WANTS SURVEY OF BERRY SITE The Massachusetts Historical Commission sent a letter to the town requesting that an archeological survey be conducted at the site of the former John T. Berry Medical Facility, a shuttered state hospital that the Burlington-based Gutierrez Company plans to redevelop with 400 housing units and 600,000 square feet of office space. According to Town Administrator Greg Balukonis, the letter, delivered last week, states that the commission believes the Berry site may have archeological significance, relying on the evidence of other ancient Indian artifacts discovered at similar sites around the Ipswich River. Gutierrez would likely bear the cost of a survey, said

Experimental evidence that global Kctd13 reduction leads to increased RhoA levels that reduce synaptic transmission, implicating RhoA as a potential therapeutic target for neuropsychiatric disorders associated with copy-number variants that include KCTD13 . Genetic insights into neuropsychiatry The 16p11.2 copy-number variant, generated by the deletion of a small piece of chromosome 16, is linked to multiple neuropsychiatric disorders, including autism. A previous study suggested that a gene within this locus, kctd13 , could be responsible for neuroanatomical abnormalities in zebrafish. Craig Powell and colleagues fail to replicate neurodevelopmental abnormalities in zebrafish or mice lacking kctd13 or Kctd13 , respectively. Rather, they observe reduced synaptic transmission, which correlates with increased levels of RhoA, a KCTD13/CUL3 ubiquitin ligase substrate. Mice lacking Kctd13 did not show many behavioural phenotypes that are signs of autism, such as social deficits or repetitive grooming. These findings do not support a model in which kctd13 or Kctd13 loss alone is responsible for autism-related behaviours, leaving open the possibility of a polygenic mechanism in 16p11.2 deletion syndrome. Copy-number variants of chromosome 16 region 16p11.2 are linked to neuropsychiatric disorders 1 , 2 , 3 , 4 , 5 , 6 and are among the most prevalent in autism spectrum disorders 1 , 2 , 7 . Of many 16p11.2 genes, Kctd13 has been implicated as a major driver of neurodevelopmental phenotypes 8 , 9 . The function of KCTD13 in the mammalian brain, however, remains unknown. Here we delete the Kctd13 gene in mice and demonstrate reduced synaptic transmission. Reduced synaptic transmission correlates with increased levels of Ras homolog gene family, member A (RhoA), a KCTD13/CUL3 ubiquitin ligase substrate, and is reversed by RhoA inhibition, suggesting increased RhoA as an important mechanism. In contrast to a previous knockdown study 8 , deletion of Kctd13 or kctd13 does not increase brain size or neurogenesis in mice or zebrafish, respectively. These findings implicate Kctd13 in the regulation of neuronal function relevant to neuropsychiatric disorders and clarify the role of Kctd13 in neurogenesis and brain size. Our data also reveal a potential role for RhoA as a therapeutic target in disorders associated with KCTD13 deletion.

Tissue macrophages have an embryonic origin and can be replenished in some tissues under steady-state conditions by blood monocytes. However, little is known about the residency and properties of infiltrating monocytes after an inflammatory challenge. The meninges of the central nervous system (CNS) are populated by a dense network of macrophages that act as resident immune sentinels. Here we show that, following lymphocytic choriomeningitis virus infection, resident meningeal macrophages (MMs) acquired viral antigen and interacted directly with infiltrating cytotoxic T lymphocytes, which led to macrophage depletion. Concurrently, the meninges were infiltrated by inflammatory monocytes that engrafted the meningeal niche and remained in situ for months after viral clearance. This engraftment led to interferon-γ-dependent functional changes in the pool of MMs, including loss of bacterial and immunoregulatory sensors. Collectively, these data indicate that peripheral monocytes can engraft the meninges after an inflammatory challenge, imprinting the compartment with long-term defects in immune function. The central nervous system meninges have a dense network of yolk sac–derived macrophages that serve a sentinel role. McGavern and colleagues show that this meningeal niche is replenished by bone marrow–derived inflammatory monocytes, which alters meningeal immune reactions after subsequent immune challenge.

The Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial showed that apixaban is better than warfarin at prevention of stroke or systemic embolism, causes less bleeding, and results in lower mortality. We assessed in this trial's participants how results differed according to patients' CHADS2, CHA2DS2VASc, and HAS-BLED scores, used to predict the risk of stroke and bleeding. ARISTOTLE was a double-blind, randomised trial that enrolled 18 201 patients with atrial fibrillation in 39 countries. Patients were randomly assigned apixaban 5 mg twice daily (n=9120) or warfarin (target international normalised ratio 2·0–3·0; n=9081). The primary endpoint was stroke or systemic embolism. The primary safety outcome was major bleeding. We calculated CHADS2, CHA2DS2VASc, and HAS-BLED scores of patients at randomisation. Efficacy analyses were by intention to treat, and safety analyses were of the population who received the study drug. ARISTOTLE is registered with ClinicalTrials.gov, number NCT00412984. Apixaban significantly reduced stroke or systemic embolism with no evidence of a differential effect by risk of stroke (CHADS2 1, 2, or ≥3, p for interaction=0·4457; or CHA2DS2VASc 1, 2, or ≥3, p for interaction=0·1210) or bleeding (HAS-BLED 0–1, 2, or ≥3, p for interaction=0·9422). Patients who received apixaban had lower rates of major bleeding than did those who received warfarin, with no difference across all score categories (CHADS2, p for interaction=0·4018; CHA2DS2VASc, p for interaction=0·2059; HAS-BLED, p for interaction=0·7127). The relative risk reduction in intracranial bleeding tended to be greater in patients with HAS-BLED scores of 3 or higher (hazard ratio [HR] 0·22, 95% CI 0·10–0·48) than in those with HAS-BLED scores of 0–1 (HR 0·66, 0·39–1·12; p for interaction=0·0604). Because apixaban has benefits over warfarin that are consistent across patient risk of stroke and bleeding as assessed by the CHADS2, CHA2DS2VASc, and HAS-BLED scores, these scores might be less relevant when used to tailor apixaban treatment to individual patients than they are for warfarin. Further improvement in risk stratification for both stroke and bleeding is needed, particularly for patients with atrial fibrillation at low risk for these events. Bristol-Myers Squibb and Pfizer.