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"Alexander, Elizabeth"
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The light of the world : a memoir
In THE LIGHT OF THE WORLD, Elizabeth Alexander finds herself at an existential crossroads after the sudden death of her husband. Channeling her poetic sensibilities into a rich, lucid prose, Alexander presents us with the heartrending story of a soul mate found and lost. As she reflects on the beauty of her married life, the trauma resulting from her husband's death, and the solace found in caring for her two sons. Alexander universalizes a very personal quest for meaning in the wake of loss. The Light of the World is at once an endlessly compelling memoir and a deeply felt meditation on the blessings of love, family, art, and community. It is also a lyrical celebration of a life well-lived and a paean to the enduring gift of human companionship. For those who have loved and lost, or for anyone who cares about what matters most, The Light of the World is required reading.--Cover page [4].
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Going It Alone Won't Work! The Relational Imperative for Social Innovation in Social Enterprises
Shifts in the philosophy of the \"state\" and a growing emphasis on the \"Big Society\" have placed an increasing onus on a newly emerging organizational form, social enterprises, to deliver innovative solutions to ease societal issues. However, the question of how social enterprises manage the process of social innovation remains largely unexplored. Based on insights from both in-depth interviews and a quantitative empirical study of social enterprises, this research examines the role of stakeholder relationships in supporting the process of social innovation within social enterprises. We find that social enterprises are adept at working with their stakeholders in the ideation stage of social innovation. In contrast, they often fail to harness knowledge and expertise from their partners during the social innovation implementation phase. Consequently, we propose a social innovationstakeholder relationship matrix that provides social enterprises in particular with insight for developing stakeholder relationships to achieve their social innovation missions.
Journal Article
The light of the world : a memoir
In THE LIGHT OF THE WORLD, Elizabeth Alexander finds herself at an existential crossroads after the sudden death of her husband. Channeling her poetic sensibilities into a rich, lucid prose, Alexander presents us with the heartrending story of a soul mate found and lost. As she reflects on the beauty of her married life, the trauma resulting from her husband's death, and the solace found in caring for her two sons. Alexander universalizes a very personal quest for meaning in the wake of loss. The Light of the World is at once an endlessly compelling memoir and a deeply felt meditation on the blessings of love, family, art, and community. It is also a lyrical celebration of a life well-lived and a paean to the enduring gift of human companionship. For those who have loved and lost, or for anyone who cares about what matters most, The Light of the World is required reading.--Cover page [4].
Book
Ubiquilin 2 modulates ALS/FTD-linked FUS–RNA complex dynamics and stress granule formation
The ubiquitin-like protein ubiquilin 2 (UBQLN2) has been genetically and pathologically linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but its normal cellular functions are not well understood. In a search for UBQLN2-interacting proteins, we found an enrichment of stress granule (SG) components, including ALS/FTD-linked heterogeneous ribonucleoprotein fused in sarcoma (FUS). Through the use of an optimized SG detection method, we observed UBQLN2 and its interactors at SGs. A low complexity, Sti1-like repeat region in UBQLN2 was sufficient for its localization to SGs. Functionally, UBQLN2 negatively regulated SG formation. UBQLN2 increased the dynamics of FUS–RNA interaction and promoted the fluidity of FUS–RNA complexes at a single-molecule level. This solubilizing effect corresponded to a dispersal of FUS liquid droplets in vitro and a suppression of FUS SG formation in cells. ALS-linked mutations in UBQLN2 reduced its association with FUS and impaired its function in regulating FUS–RNA complex dynamics and SG formation. These results reveal a previously unrecognized role for UBQLN2 in regulating the early stages of liquid–liquid phase separation by directly modulating the fluidity of protein–RNA complexes and the dynamics of SG formation.
Journal Article
The essential Gwendolyn Brooks
A selection of the influential African-American poet's works reflects her modernist style and includes numerous definitive World War II poems as well as pieces about the social and political upheavals of the 1960s.
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Effect and Safety of Meropenem–Vaborbactam versus Best-Available Therapy in Patients with Carbapenem-Resistant Enterobacteriaceae Infections: The TANGO II Randomized Clinical Trial
IntroductionTreatment options for carbapenem-resistant Enterobacteriaceae (CRE) infections are limited and CRE infections remain associated with high clinical failure and mortality rates, particularly in vulnerable patient populations. A Phase 3, multinational, open-label, randomized controlled trial (TANGO II) was conducted from 2014 to 2017 to evaluate the efficacy/safety of meropenem–vaborbactam monotherapy versus best available therapy (BAT) for CRE.MethodsA total of 77 patients with confirmed/suspected CRE infection (bacteremia, hospital-acquired/ventilator-associated bacterial pneumonia, complicated intra-abdominal infection, complicated urinary tract infection/acute pyelonephritis) were randomized, and 47 with confirmed CRE infection formed the primary analysis population (microbiologic-CRE-modified intent-to-treat, mCRE-MITT). Eligible patients were randomized 2:1 to meropenem–vaborbactam (2 g/2 g over 3 h, q8h for 7–14 days) or BAT (mono/combination therapy with polymyxins, carbapenems, aminoglycosides, tigecycline; or ceftazidime-avibactam alone). Efficacy endpoints included clinical cure, Day-28 all-cause mortality, microbiologic cure, and overall success (clinical cure + microbiologic eradication). Safety endpoints included adverse events (AEs) and laboratory findings.ResultsWithin the mCRE-MITT population, cure rates were 65.6% (21/32) and 33.3% (5/15) [95% confidence interval (CI) of difference, 3.3% to 61.3%; P = 0.03)] at End of Treatment and 59.4% (19/32) and 26.7% (4/15) (95% CI of difference, 4.6% to 60.8%; P = 0.02) at Test of Cure;.Day-28 all-cause mortality was 15.6% (5/32) and 33.3% (5/15) (95% CI of difference, − 44.7% to 9.3%) for meropenem–vaborbactam versus BAT, respectively. Treatment-related AEs and renal-related AEs were 24.0% (12/50) and 4.0% (2/50) for meropenem–vaborbactam versus 44.0% (11/25) and 24.0% (6/25) for BAT. Exploratory risk–benefit analyses of composite clinical failure or nephrotoxicity favored meropenem–vaborbactam versus BAT (31.3% [10/32] versus 80.0% [12/15]; 95% CI of difference, − 74.6% to − 22.9%; P < 0.001).ConclusionsMonotherapy with meropenem–vaborbactam for CRE infection was associated with increased clinical cure, decreased mortality, and reduced nephrotoxicity compared with BAT.Clinical Trials RegistrationNCT02168946.FundingThe Medicines Company.
Journal Article
Miss Crandall's school for young ladies and little misses of color : poems
Poets Elizabeth Alexander and Marilyn Nelson tell the story of Prudence Crandall's school for African American girls opened in 1833.
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Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY
Global regulators that bind strategic metabolites allow bacteria to adapt rapidly to dynamic environments by coordinating the expression of many genes. We report an approach for determining gene regulation hierarchy using the regulon of the Bacillus subtilis global regulatory protein CodY as proof of principle. In theory, this approach can be used to measure the dynamics of any bacterial transcriptional regulatory network that is affected by interaction with a ligand. In B. subtilis , CodY controls dozens of genes, but the threshold activities of CodY required to regulate each gene are unknown. We hypothesized that targets of CodY are differentially regulated based on varying affinity for the protein’s many binding sites. We used RNA sequencing to determine the transcription profiles of B. subtilis strains expressing mutant CodY proteins with different levels of residual activity. In parallel, we quantified intracellular metabolites connected to central metabolism. Strains producing CodY variants F71Y, R61K, and R61H retained varying degrees of partial activity relative to the WT protein, leading to gene-specific, differential alterations in transcript abundance for the 223 identified members of the CodY regulon. Using liquid chromatography coupled to MS, we detected significant increases in branched-chain amino acids and intermediates of arginine, proline, and glutamate metabolism, as well as decreases in pyruvate and glycerate as CodY activity decreased. We conclude that a spectrum of CodY activities leads to programmed regulation of gene expression and an apparent rerouting of carbon and nitrogen metabolism, suggesting that during changes in nutrient availability, CodY prioritizes the expression of specific pathways.
Journal Article
The crisis of journalism reconsidered : democratic culture, professional codes, digital future
\"This collection of original essays brings a dramatically different perspective to bear on the contemporary \"crisis of journalism.\" Rather than seeing technological and economic change as the primary causes of current anxieties, The Crisis of Journalism Reconsidered draws attention to the role played by the cultural commitments of journalism itself. Linking these professional ethics to the democratic aspirations of the broader societies in which journalists ply their craft, it examines how the new technologies are being shaped to sustain value commitments rather than undermining them. Recent technological change and the economic upheaval it has produced are coded by social meanings. It is this cultural framework that actually transforms these \"objective\" changes into a crisis. The book argues that cultural codes not only trigger sharp anxiety about technological and economic changes, but provide pathways to control them, so that the democratic practices of independent journalism can be sustained in new forms\"-- Provided by publisher.
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Shifting logics: limitations on the journey from 'state' to 'market' logic in UK higher education
Our study of UK higher education institutions (HEIs) offers insights into the role of institutional logics in the adoption of organisational practices - specifically outsourcing. We identify two logics prevalent within HEIs: a public service 'state logic' and a 'market logic'. While adherence to the market logic supports commercial-based practices such as outsourcing, organisations enact competing logics in complex ways. Outsourcing is mainly limited to peripheral activities segmented from the core while a nascent cooperative solution is emerging as HEIs co-opt practices and discourse of outsourcing to justify hybrid relationships that marry competing logics in a process of selective coupling.
Journal Article